THBS1 is a new autosomal recessive non-syndromic hearing impairment gene by Thashi Bharadwaj, Anushree Acharya, Fati Ullah Khan, Saadullah Khan, Irfan Ullah, Isabelle Schrauwen, Wasim Ahmad, Suzanne M. Leal

“…Using Sanger sequencing select variants were validated and tested for segregation using DNA samples from additional family members. …”
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Life cycle assessment of an entirely wood floor system designed for carbon negativity, future adaptability, and end-of-life de/re/construction by Muzan Williams Ijeoma, Sovanroth Ou, Amin Nabati, Hao Chen, Michael Stoner, Patricia Layton, Dustin Albright, Brandon Ross, Weichiang Pang, Michael Carbajales-Dale

“…Mass timber offers a promising alternative, with lower embodied carbon (EC) and the potential to function as a carbon sink when sustainably sourced. …”
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SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 2; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. The method marks anomalies in data using five moving windows. …”
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Untargeted metabolomics reveals stage-specific metabolic signatures in yak colostrum, transitional milk and mature milk by Yunduan Wang, Daoliang Lan, Shaohui Beng, Shunyang Liu, Xueer Mu, Kechao Chen, Yueyue Li, Meng Xu, Jian Li, Wei Fu

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Clinical and economic effectiveness of Schroth therapy in adolescent idiopathic scoliosis: insights from a machine learning- and active learning-based real-world study by Erdal Ayvaz, Merve Uca, Ednan Ayvaz, Zafer Yıldız

“…Results Exercise-based therapy resulted in a mean Cobb angle reduction of 6.8° (SD = 3.1), with significant improvements in pain and function (p < 0.001). The ICER was estimated at $1,730 per additional degree of Cobb angle correction, with a projected QALY gain of 0.03 per patient. …”
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Analysis of random factors of the self-education process by A. A. Solodov

“…These numbers are interpreted as a resource (price), which is consumed with the appearance of each event and are mapped to external factors selflearning process.For each private model provided optimal algorithms for estimating the relevant factors according to selected criteria, in the simplest cases, the analytical expressions are indicated. …”
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Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Secondary outcomes: clinical-/patient-reported outcomes. Data sources Seven primary studies databases; Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, Health Technology Assessment Database and Trial Registers to 31 August 2023. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…Elevation, precipitation, village density, and PA size did not substantially influence occupancy. Black bear detection probability became 100 % only above 14 km survey effort, indicating its overall rarity, and bears were much more easily detected during and after rainfall. …”
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Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation by Jingyi Hou, Jingyi Hou, Jingyi Hou, Lihan Wang, Lihan Wang, Naiqiang Zhu, Xueli Li

“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model by Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon

“…Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. …”
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Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects by Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge, Navnath S. Gavande

“…Particular attention is given to the role of USP inhibitors in enhancing cancer immunotherapy, e.g., modulation of the tumor microenvironment, effect on regulatory T cell function, and influence on immune checkpoint pathways. …”
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Palm-size wireless piezoelectric immune-biosensing system for rapid E. coli O157:H7 detection by Yang Tian, Lisa Kelso, Yiting Xiao, Chaitanya Pallerla, Ramesh Bist, Siavash Mahmoudi, Ziyu Liu, Haizheng Xiong, Jeyam Subbiah, Terry Howell, Dongyi Wang

“…The system integrates a gold-coated quartz crystal microbalance (QCM) sensor functionalized with protein A-immobilized antibodies, a polydimethylsiloxane (PDMS) microfluidic channel for efficient sample handling, and a flexible loop antenna for wireless signal transmission. …”
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Inoculum of Endophytic <i>Bacillus</i> spp. Stimulates Growth of Ex Vitro Acclimatised Apple Plantlets by Jurgita Vinskienė, Inga Tamošiūnė, Elena Andriūnaitė, Dalia Gelvonauskienė, Rytis Rugienius, Muhammad Fahad Hakim, Vidmantas Stanys, Odeta Buzaitė, Danas Baniulis

“…In vitro shoot culture and cryopreservation (CP) are techniques essential for the ex situ preservation of genetic resources and the production of plant propagation material of clonally propagated horticultural crops. …”
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Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal c... by Ming Zhang, Yani Su, Pengfei Wen, Xiaolong Shao, Peng Yang, Peng An, Wensen Jing, Lin Liu, Zhi Yang, Mingyi Yang

“…Data on 23 m6A regulators and 25 cuproptosis-related genes were sourced from the latest literature. The m6aCRLncs linked to EC were identified through co-expression analysis. …”
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Rapid parameter estimation for merging massive black hole binaries using continuous normalizing flows by Bo Liang, Minghui Du, He Wang, Yuxiang Xu, Chang Liu, Xiaotong Wei, Peng Xu, Li-e Qiang, Ziren Luo

“…Detecting the coalescences of massive black hole binaries (MBHBs) is one of the primary targets for space-based gravitational wave observatories such as laser interferometer space antenna, Taiji, and Tianqin. …”
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Effects of different hormones on the color of tree peony leaves by Zihan Yang, Shuiyan Yu, Shanrong Dong, Chenxi Wei, Yingan Niu, Xiaoman Wang, Jianrang Luo

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Developing a Digital Tool to Calculate Protein Quality in Plant-Based Meals of Older Adults: User Engagement Design Approach With End Users by Lotte van Dam, Sine Højlund Christensen, Inge Tetens, William Riley III, Mariëlle Timmer, George Suciu Jr, Iuliana Marin, Lisette De Groot, Pol Grootswagers

“…The user-task-environment analysis delivered input among others that dietitians and older adults are good potential users, the tool should be functional as an app as well as a website and the tool should provide preprogrammed meals or recipes. …”
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A Systematic Review on Insights to Community Medicine and Clinical Research: Competency Training in Medical and Dental Education by Madeeha Minhas, Bilal Masood, Muhammad Hassaan Saeed, Amna Iqbal Butt, Fareed Ud Din Ahmad Chishti, Fatima Ali

“…Discussion: Effective competency training curricula substantially enhanced the functioning of healthcare systems and results for patients. …”
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Study on Decision-Making Factors for Patient Disposition by Rehabilitation Outpatient Physicians by LI Yawei, YE Ruixue, GAO Yan, HAO Yingzi, LI Xiaoxuan, WANG Yuqi, WANG Yulong

“…ObjectiveThis study takes Shenzhen as an example to explore the influencing factors of physicians' referral decisions for outpatient rehabilitation patients under the hierarchical medical system, aiming to provide useful references for improving the allocation of medical resources and optimizing the rehabilitation hierarchical medical system.MethodsThe study selected one tertiary hospital, two secondary general hospitals, and three primary healthcare institutions (i.e., community health service centers) in Shenzhen as research sites from September to November 2023. …”
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Sigesbeckia pubescens makino alleviates ulcerative colitis in mice by modulating the Nrf2/Keap1 pathway by Qiu-Shuo Ma, Qi-Ling Chen, Guo-Ping Wu, Ya-Wen Yao, Yu-Xin Fan, Ke-Gang Linghu, Jun-Ming Chen, Wei Xiong, Hua Yu, Hua Yu

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