Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer by Khanittha Laowichuwakonnukul, Boonchoy Soontornworajit, Jiraporn Arunpanichlert, Pichayanoot Rotkrua

“…The protein expression of procaspase-3 and Bcl-2 was decreased, while Bax was increased, confirming that Dox-MAH triggered the cell apoptosis. The success of this research proposed a new strategy for a drug delivery system, which has multiple functions simultaneously; CRC cell-specificity, Dox carrier, and miR-143 delivery.…”
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Endodontic treatment of teeth with a wide apical opening – a clinical case by V. A. Popov, E. S. Pestova, S. A. Anisimova

“…The presented clinical case demonstrates the successful endodontic treatment of a tooth in a teenager, in which treatment tactics aimed at stimulating apexification were applied. …”
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Consistent microbial insights across sequencing methods in soil studies: the role of reference taxonomies by Niranjana Rose Edwin, Aoife Duff, Coline Deveautour, Fiona Brennan, Florence Abram, Orla O'Sullivan

“…Our findings reveal that both methods offer moderately similar outcomes, providing consistent detection of major phyla, similar microbial community differentiation patterns, and largely identifying the same relationships between the phyla and nitrogen functions. …”
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Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma by Mingjun Gao, Mengmeng Wang, Siding Zhou, Jiaqi Hou, Wenbo He, Yusheng Shu, Xiaolin Wang

“…Finally, we analyzed the expression of KRT81 in LUAD tissues and cell lines using qRT-PCR, WB, and IHC. Changes in KRT81 function in LUAD cells were detected by CCK-8, colony formation, wound healing, transwell, and flow cytometry. …”
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Development of a Rapid UPLC Method for Analysis of Carotenoids in Goji Berry Extract and Evaluation of Their Transformation Affected by Saponification by Bo-Yang Hsu, Chia-Hui Lin, Tsai-Hua Kao

“…This method successfully separates 17 carotenoids and their esters within 21 min using a Sunrise C30 column, with detection at 450 nm, a flow rate of 1.3 mL/min, and a column temperature of 25 °C. …”
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TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Mel... by Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson, Ulf Dyrke, Dimitrios Papantoniou, Anders Sundin, Gustav J. Ullenhag

“…Early onset of treatment seems to improve outcome, which suggests that early detection of recurrent disease should be beneficial. …”
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Growth Toxic Effects of Metal Nanoparticles on Bacillus subtilis and Vibrio parahaemolyticus by Shiyu CHEN, Bin XIA, Lin ZHU, Shuang LI, Qiufen LI, Xuemei SUN, Wei DAI

“…Based on the ecological roles and functions of these two bacteria in marine microbial communities, this study used B. subtilis and V. parahaemolyticus isolated from Bohai Bay as test organisms. …”
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In vitro regeneration and phytochemical evaluation of pippali (Piper longum) for conservation and therapeutic applications by ARIJITA MOHANTY, JYOTI PRAKASH SAHOO, KAILASH CHANDRA SAMAL

“…Infrared (IR) absorption analysis identified functional groups such as alcohols, amides, alkanes and carboxylic acids. …”
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Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease Using MRI BOLD and ASL Techniques by Renata F. Leoni, Kelley C. Mazzetto-Betti, Afonso C. Silva, Antonio C. dos Santos, Draulio B. de Araujo, João P. Leite, Octavio M. Pontes-Neto

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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces by Wenjing Lu, Biqing Zha, Jie Lyu, Chenxi LingHu, Jing Chen, Sisi Deng, Xiangling Zhang, Liang Li, Guoqing Wang

“…Two annotated regions of secondary metabolite biosynthesis genes, both belonging to Terpene, were detected using the antiSMASH online tool.ConclusionThese findings indicate that the four Akkermansia isolates, which belong to a phylogroup distinct from the model strain DSM 22959, exhibit lower genetic risk and may serve as potential probiotic resources for future research.…”
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Distribution, Occupancy, and Habitat of the Endangered Carolina Madtom: Implications for Recovery of an Endemic Stream Fish by W. Robert Cope, Thomas J. Kwak, Tyler R. Black, Krishna Pacifici, Jennifer M. Archambault, W. Gregory Cope

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Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing by Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li

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Assessment of the capacity of health facilities in preventing and managing non-communicable diseases in selected regions of Somaliland by Opeolu O. Ojo, Omar O Hersi, Ayodele A Falobi, Nura Ali, Lawrence Tan, Yusuf A. Ali

“…The impact of location, level of care provided and source of funding on the capacity of hospitals was assessed. …”
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Development of grain drink technology based on unsteamed buckwheat by G. M. Kerimova, I. A. Fomenko, A. R. Pivchenko, I. R. Sokolov

“…In the finished drink, the final indicators of the content of  protein, fat, reducing substances, dry substances have been detected. The finished product is also a source  of soluble dietary fiber, which has a positive effect on the human microbiome.…”
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Introducing the English EmpaToM task: A tool to assess empathy, compassion, and theory of mind in fMRI studies by Dorottya Lantos, Celeste Costa, Matthew Briglia, Pascal Molenberghs, Philipp Kanske, Tania Singer

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Levels of amino acids and homoarginine in the venous basins of the brain and the heart muscle in patients with ischemic heart disease by N. S. Molchan, T. Yu. Reypol'skaya, T. F. Subbotina, A. A. Zhloba, Yu. S. Polushin

“…Under the conditions of circulatory disorders and coronary heart disease (CHD), amino acids acquire additional value as a source of intermediates of Krebs cycle, participating in cell energetics. …”
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Enzymatic system of glucose metabolism in Gluconobacter oxydans strain DHA3-9 by Li Qianyan, Lu Xiangfeng, Zhang Pengcheng, Sun Lingyan, Liu Yu, Ma Xiaohang

“…Pyruvate and acetate were detected in the products of mutant whereas none of such products were found in wild type culture. …”
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Experimental Study of Coherent Collaborative Processing Method in Distributed Automotive Radar by A. A. Kuzin, S. E. Kuznetsov, A. V. Miakinkov, R. S. Fadeev, S. A. Shabalin

“…Intelligent driver assistance systems are increasingly employing radar systems to detect, resolve, and track various classes of targets. …”
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A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila. by Aidan J Peterson, Stephen J Murphy, Melinda G Mundt, MaryJane Shimell, Edward B Leof, Michael B O'Connor

“…Wit, a second Type II receptor, shows a markedly different behavior, with the protein detected on all membrane regions but enriched at the apical side. …”
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