Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
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Genomic signal selection analysis reveals genes related to the lambing trait of Hotan sheep by XinKun Wang, Wei Li, QiaoYan Huang, HuiPing Sun, LeXiao Zhu, RuoHuai Gu, Feng Xing

“…We identified 290 selected regions and 332 genes across the Hotan sheep genome by using two widely adopted selective scanning detection methods (FST statistics and Piratio). Functional annotation and enrichment analysis of these genes identified 13 genes associated with the lambing rate, which were enriched in pathways such as the transforming growth factor-β signaling pathway (BMPR2, ID2, SMAD7, THBS1, and RBX1), renal cell carcinoma (PAK1, ELOC), inositol phosphate metabolism (PLCZ), non-homologous terminal junction (RAD50), ABC transporters (ABCC4), and the NET pathway (H2B, H4, and H2A). …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Systematic reviews of transition interventions reveal that most include multiple elements, with strategies prior to and following discharge and variable success. Knowing which of these elements represent the active ingredients is important for the management of scarce resources. …”
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Data Mining–Based Model for Computer-Aided Diagnosis of Autism and Gelotophobia: Mixed Methods Deep Learning Approach by Mohamed Eldawansy, Hazem El Bakry, Samaa M Shohieb

“…This comorbidity can significantly impair the quality of life, particularly in adolescents with high-functioning ASD, where the prevalence reaches 41.98%. …”
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Different Commercial Microbial Additives Influence Fermentation Quality and Microbial Community of King Grass Silage by Xianjun Lai, Haiyan Wang, Rui Peng, Zihan Chen, Yuxin Xiang, Lang Yan

“…Additive-treated silages showed improved fermentation quality, simplified bacterial correlation networks, and distinct microbial successions and interactions. A total of 1523 metabolites were detected, with 56–84 significantly altered in each treated group compared to the control. …”
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IT: An interpretable transformer model for Alzheimer's disease prediction based on PET/MR images by Zhaomin Yao, Weiming Xie, Jiaming Chen, Ying Zhan, Xiaodan Wu, Yingxin Dai, Yusong Pei, Zhiguo Wang, Guoxu Zhang

“…These insights significantly bolster the arsenal of tools available for AD diagnostics and contribute to the broader narrative of deciphering brain functionality through state-of-the-art imaging modalities.…”
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Transcriptome analysis reveals the mechanism of Rhodiola polysaccharide affecting the proliferation of porcine Leydig cells under hypoxia by Jinting Luo, Lei Wang, Youli Yao, Xuan Luo, Jianbo Zhang, Dandan Luo, Tian Tian, Guofang Wu

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The noise analysis and multi-physical field coupling study of high-precision SERF atomic gyroscopes by Jiaxin Liu, Xusheng Lei, Yu Yuan, Yizhe Zhou, Haoying Pang, Zhihong Wu

“…Based on the differences in the optical-magnetic response of the dual-axis signals, empirical mode decomposition was used to decompose the dual-axis gyroscope signals into multiple intrinsic mode functions, and Allan deviation analysis was applied to analyze the noise characteristics of the intrinsic mode functions over various periods. …”
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Compensation of Speckle Noise in 2D Images from Triangulation Laser Profile Sensors Using Local Column Median Vectors with an Application in a Quality Control System by Paweł Rotter, Dawid Knapik, Maciej Klemiato, Maciej Rosół, Grzegorz Putynkowski

“…The primary limitation of the proposed method is its applicability only to flat surfaces. Nonetheless, we successfully implemented it in an optical inspection system for the furniture industry, where the post-processed image quality was sufficient to detect surface defects as small as 0.1 mm.…”
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En Bloc Kidney Transplantation, The Best Option? by Mauricio Alejandro Saldaña-Ruiz, Cynthia del Carmen Cardona-Ruiz, Federico Ortiz-Alonso, Mauricio Linnery Rendón-Saldívar

“…Availability of en bloc kidneys was reported, and the transplant was performed successfully. During his post-transplant stay, he showed adequate blood flow by doppler ultrasound with no evidence of thrombosis (Figure 1) and adequate renal function. …”
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Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness. by Louis Lambrechts, Robert C Reiner, M Veronica Briesemeister, Patricia Barrera, Kanya C Long, William H Elson, Alfonso Vizcarra, Helvio Astete, Isabel Bazan, Crystyan Siles, Stalin Vilcarromero, Mariana Leguia, Anna B Kawiecki, T Alex Perkins, Alun L Lloyd, Lance A Waller, Uriel Kitron, Sarah A Jenkins, Robert D Hontz, Wesley R Campbell, Lauren B Carrington, Cameron P Simmons, J Sonia Ampuero, Gisella Vasquez, John P Elder, Valerie A Paz-Soldan, Gonzalo M Vazquez-Prokopec, Alan L Rothman, Christopher M Barker, Thomas W Scott, Amy C Morrison

“…Magnitude of viremia is the primary determinant of successful human-to-mosquito DENV transmission. People with the same level of viremia, however, can vary in their infectiousness to mosquitoes as a function of other factors that remain to be elucidated. …”
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Interleukin-15 and cancer: some solved and many unsolved questions by Gabriella Pietra, Lorenzo Moretta, Nicola Tumino, Piera Filomena Fiore, Sabina Di Matteo, Francesca Romana Mariotti, Selene Ottonello, Simone Negrini, Barbara Bottazzi, Erwan Mortier, Bruno Azzarone

“…Both forms have been successfully tested in experimental tumor murine models and are currently undergoing investigation in phase I/II clinical trials. …”
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The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression by Kai Guo, Jie Yao, Qiang Yu, Zijian Li, Hu Huang, Jianguo Cheng, Zhigang Wang, Yunfeng Zhu

“…Here, we reported for the first time that PVT1 as a long non-coding RNA was successfully detected in extracellular vesicles excluded from SW620 and SW480 cells, and the expression level of PVT1 was higher in extracellular vesicles from the more aggressive cell SW620 than from SW480. …”
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AI for rapid identification of major butyrate-producing bacteria in rhesus macaques (Macaca mulatta) by Annemiek Maaskant, Donghyeok Lee, Huy Ngo, Roy C. Montijn, Jaco Bakker, Jan A. M. Langermans, Evgeni Levin

“…The model was successful in predicting functional groups, major butyrate producers (AUC 0.75) and a mixed group including fermenters and short-chain fatty acid (SCFA) producers (AUC 0.81). …”
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Correlation and Agreement of Quantitative Flow Ratio With Fractional Flow Reserve in Saphenous Vein Grafts by Ruben W. de Winter, Yvemarie B. O. Somsen, Roel Hoek, Pepijn A. van Diemen, Ruurt A. Jukema, Mathé P. Jonker, Albert C. van Rossum, Jos W. R. Twisk, Rolf A. Kooistra, Jasper Janssen, Sina Porouchani, Adriaan Wilgenhof, Niels J. Verouden, Ibrahim Danad, Johan H. C. Reiber, Alexander Nap, Paul Knaapen

“…A threshold of ≤0.80 was used to define functional significance. QFR was successfully computed in 140 (93%) SVGs. …”
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A novel multi-timescale comprehensive drought index for drought monitoring in the Xijiang River Basin by Liping Wang, Shufang Wang, Jing Li, Xingnan Zhang

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Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study by Yejing Zhao, Yejing Zhao, Xiang Wang, Jie Zhang, Yanyan Zhao, Yi Li, Ji Shen, Ying Yuan, Jing Li

“…Between October and November 2024, a total of 146 elderly individuals diagnosed with MCI and 54 healthy elderly subjects were successfully recruited. Enzyme linked immunosorbent assay (ELISA) was used to detect plasma hub gene protein concentration. …”
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High prevalence of fecal carriage of extended-spectrum beta-lactamase producing Enterobacterales among patients with urinary tract infections in rural Tanzania by Magreth Erick Macha, Magreth Erick Macha, Magreth Erick Macha, Weihong Qi, Salome N. Seiffert, Anja Bösch, Philipp Kohler, Honorathy Msami Urassa, Sabine Haller, Erin West, Maja Weisser Rohacek, Maja Weisser Rohacek, Maja Weisser Rohacek, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury

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MaPep1 and MbPep1, as plant elicitor peptides in banana, confer resistance to banana blood disease caused by Ralstonia syzygii subsp. celebesensis by Praphat Kawicha, Ladawan Rattanapolsan, Ratri Boonruangrod, Yube Yamaguchi, Kusavadee Sangdee, Aphidech Sangdee, Thanwanit Thanyasiriwat

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Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease by Chien-Hui Chen, Chien-Hui Chen, Wei-Li Hsu, Pei-Shiue Jason Tsai, Chun-Fu Lai, Meng-Ting Wu, Ya-Jane Lee, Ya-Jane Lee

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