A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data by Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona

“…The provided computational pipeline functions as a resource to facilitate TCR profiling from RNA-seq data boosting immunophenotype analyses of immunological diseases.…”
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Research Progress on the Effect of Dissolved Organic Matter on the Environmental Behavior of Cadmium in Environmental Remediation by Jiabao MA, Siwen LIU, Bo WANG, Di WU, Jixin WEI, Qing SUN, Chenge MA, Yi HUANG, Taotao YAN

“…The various active functional groups contained in DOM, such as carboxyl, hydroxyl, and phenolic groups, are ligands and migration carriers for many heavy metals in the environment. …”
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Transcriptome analysis reveals the candidate genes associated with skin color variation in Luciobarbus capito by Longwu Geng, Xinchi Shang, Haijun Wei, Guangxiang Tong, Wei Xu, Youyi Kuang

“…The yellow Aral barbel represents a valuable germplasm resource due to its stable genetic body color and high consumer preference due to the color and market value. …”
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Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong by Xiaoqing Xu, Yunqi Lin, Yu Deng, Lei Liu, Dou Wang, Qinling Tang, Chunxiao Wang, Xi Chen, You Che, Ethan R. Wyrsch, Veronica M. Jarocki, Steven P. Djordjevic, Tong Zhang

“…Additionally, 195 plasmids were shared across all three source-attributed sectors. Conjugation assays confirmed that several plasmids were functionally transmissible across ecological boundaries. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Adolescent adaptive functioning was predicted not only by early childhood autistic symptoms and IQ and ADHD symptoms. …”
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Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

“…Our data represent the first large‐scale interactome mapping for human GPCRs and provide a valuable resource for the analysis of signaling pathways involving this druggable family of integral membrane proteins.…”
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Iodine deficiency as an environmental risk factor for thyroid gland diseases in animals by І. P. Ligomina, I. M. Sokulskyi, V. M. Sokolyuk, B. V. Gutyj, L. M. Soloviova

“…It was observed that goiter was established in only three cows out of 90 (3.35%); all were in Narodytsky district (6.7 %). Enophthalmos was detected in 24 out of 90 dairy cows (26.7 %), including 16 out of 45 cows (35.4 %) in the Narodytsky District, while this symptom was not detected in the Popilnya District dairy cows. …”
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Rossby Number Regime, Convection Suppression, and Dynamo-generated Magnetism in Inflated Hot Jupiters by Albert Elias-López, Matteo Cantiello, Daniele Viganò, Fabio Del Sordo, Simranpreet Kaur, Clàudia Soriano-Guerrero

“…Specifically, we obtain the Rossby number Ro as a function of planetary depth and orbital period, after showing that tidal synchronization is likely valid for all HJs. …”
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Hypoglycemic, Antioxidant Activities, and Probiotic Characteristics of <i>Lacticaseibacillus rhamnosus</i> LBUX2302 Isolated from Stool Samples of Neonates by Pedro A. Reyes-Castillo, Ana Laura Esquivel-Campos, Edgar Torres-Maravilla, Eduardo Zúñiga-León, Felipe Mendoza-Pérez, Rosa González-Vázquez, María Guadalupe Córdova-Espinoza, María Angélica Gutiérrez-Nava, Raquel González-Vázquez, Lino Mayorga-Reyes

“…Finally, the presence of ferulic acid activity was detected. The results highlight <i>L. rhamnosus</i> LBUX2302 as a promising probiotic with hypoglycemic and antioxidant effects, warranting further in vivo evaluation for its possible inclusion in functional food and health formulations.…”
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Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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Effects of soil water on fungal community composition along elevational gradients on the northern slope of the Central Kunlun Mountains by Yongguang Zhang, Yongguang Zhang, Chaonan Li, Zhihao Zhang, Chenhong Li, Bo Zhang, Hongchen Jiang, Waqar Islam, Xiangzhen Li, Fanjiang Zeng

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Camellia sinensis phytochemical profiling, drug-likeness, and antibacterial activity against gram-positive and gram-negative bacteria: in vitro and in silico insights by Farouk Boudou, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum, Ahmed Barhoum

“…Drug-likeness modeling indicated favorable profiles for most compounds, although EGCG violated Lipinski’s rule due to its molecular weight (458.4 g/mol). Density Functional Theory analysis revealed significant variations in electronic properties among the selected compounds, with quercetin exhibiting the smallest HOMO-LUMO gap (2.31 eV), suggesting high reactivity. …”
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Effect of Perfluorane on Electric Pulse-Modified Red Blood Cell Membranes by V. V. Moroz, Ye. K. Kozlova, M. S. Bogushevich, P. Yu. Alekseyeva, A. M. Chernysh

“…The induced calibrated electroporation of the membranes permitted the detection of the masked effects of perfluorane on blood cells. …”
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Quantification of glucagon and oxyntomodulin by protein precipitation-immunoaffinity enrichment-LC-MS/MS by Jessica O. Becker, Sara K. Shijo, Huu-Hien Huynh, Katrina L. Forrest, Michael J. MacCoss, Michelle A. Emrick, Elisha Goonatilleke, Andrew N. Hoofnagle

“…A glucagon calibration material was sourced commercially and characterized for purity and concentration by high-performance liquid chromatography-ultraviolet detection and amino acid analysis. …”
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Genomic Sequencing and Characterization of Two <i>Auricularia</i> Species from the Qinling Region: Insights into Evolutionary Dynamics and Secondary Metabolite Potential by Jianzhao Qi, Shijie Kang, Ming Zhang, Shen Qi, Yulai Li, Khassanov Vadim, Shuangtian Du, Minglei Li

“…These results not only enriched our understanding of the <i>Auricularia</i> genome but also provided an important genomic resource and theoretical basis for the subsequent genetic breeding, functional gene mining, and development of medicinal components of <i>Auricularia</i> species.…”
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Impact of gut microbial diversity on egg production performance in chickens by Liping Wu, Tao Zhang, Zhihua Luo, Huiyuan Xiao, Di Wang, Cailong Wu, Xinyan Fang, Jiawei Li, Jing Zhou, Junjie Miao, Hongli Tan, Yanan Wang, Qing Liu, Jianhua Huang

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Synergizing Multi-Temporal Remote Sensing and Systemic Resilience for Rainstorm–Flood Risk Zoning in the Northern Qinling Foothills: A Geospatial Modeling Approach by Dong Liu, Jiaqi Zhang, Xin Wang, Jianbing Peng, Rui Wang, Xiaoyan Huang, Denghui Li, Long Shao, Zixuan Hao

“…This framework quantitatively evaluates the nonlinear response mechanisms of town–village systems to flood disasters, emphasizing the synergistic effects of spatial scale, morphology, and functional organization. The proposed framework uniquely integrates three innovative modules: (1) a hybrid risk identification engine combining normalized difference vegetation index (NDVI) temporal anomaly detection and spatiotemporal hotspot analysis; (2) a morpho-functional resilience quantification model featuring a newly developed spatial morphological resilience index (SMRI) that synergizes landscape compactness, land-use diversity, and ecological connectivity through the entropy-weighted analytic hierarchy process (AHP); and (3) a dynamic scenario simulator embedding rainfall projections into a coupled hydrodynamic model. …”
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The combined effects of climate, soil, and rhizospheric microorganisms determine the quality and suitable production zones of Stellaria dichotoma L. var. lanceolata Bge. in China by Zhenkai Li, Yang Yang, Lu Feng, Haishan Li, Zhiheng Dai, Tianle Cheng, Shuying Liu, Ling Ma, Xin Luo, Yukun Wang, Li Peng, Hong Wu

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Digital Twin-Based Technical Research on Comprehensive Gear Fault Diagnosis and Structural Performance Evaluation by Qiang Zhang, Zhe Wu, Boshuo An, Ruitian Sun, Yanping Cui

“…However, the current gear operation is still faced with problems such as poor monitoring, a single detection index, and low data utilization, which lead to incomplete evaluation results. …”
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Unveiling smart contract vulnerabilities: Toward profiling smart contract vulnerabilities using enhanced genetic algorithm and generating benchmark dataset by Sepideh HajiHosseinKhani, Arash Habibi Lashkari, Ali Mizani Oskui

“…This dataset consists of 111,897 Solidity source code samples, ensuring the practical validation of the proposed approach. …”
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