BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity by Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

“…Abstract Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. …”
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Integrating isotopic niche metrics and gut microbiota assembly reveals coexistence mechanisms in subtropical riverine fish by Yaqiu Liu, Xinhui Li, Konstantinos Ar. Kormas, Chunni Kou, Huifeng Li, Yuefei Li, Jie Li

“…Crucially, we identified the similarity of the intestinal microbial community structure is closely related to the degree of overlap of its nutritional ecological niche, indicating functional convergence between host trophic niches and their symbiotic microbiomes.These microbial adaptations facilitate nutritional optimization from varied trophic sources, mediate interspecific resource partitioning, and expand ecological opportunities within the fish community. …”
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Photonics-Aided THz Integrated Sensing and Communication System Based on a Subcarrier-Chirp Inter-Embedded Waveform by Junhao Zhang, Mingzheng Lei, Min Zhu, Qingzhi Zhou, Bingchang Hua, Yuancheng Cai, Hao Li, Jiao Zhang, Zhengyi Liang, Yang Li, Xingyu Chen, Junjie Ding, Qing Zhong, Sha Zhu, Jianjun Yu

“…Simultaneously, multi-user detection with an 8-mm ranging resolution is also realized. …”
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Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
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IT: An interpretable transformer model for Alzheimer's disease prediction based on PET/MR images by Zhaomin Yao, Weiming Xie, Jiaming Chen, Ying Zhan, Xiaodan Wu, Yingxin Dai, Yusong Pei, Zhiguo Wang, Guoxu Zhang

“…These insights significantly bolster the arsenal of tools available for AD diagnostics and contribute to the broader narrative of deciphering brain functionality through state-of-the-art imaging modalities.…”
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Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Subsequently, the interrelationship between topological metrics and vegetation CUE was analyzed, and optimization strategies were proposed based on the significance of the structure and function. The findings revealed that: (1) Vegetation CUE exhibited a spatially decreasing trend from the western to eastern regions, with spatial patterns correlated with vegetation types, temperature, and precipitation distribution; (2) The ecological spatial network demonstrated a denser configuration in the upper and middle reaches and a sparser and shorter pattern in the lower reaches, with seamless connectivity among all regions; (3) Significant correlations were observed between topological metrics and vegetation CUE, prompting the adoption of ecological construction and protection measures when functional importance is deficient, and enhancing the connectivity of ecological sources through the augmentation of ecological corridors when structural importance is lacking. …”
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NaCl-induced soil stress regulates the diversity of soil bacteria and their ability to metabolize low molecular weight organic acids by Adhari Al-Kalbani, Daniel Menezes-Blackburn, Jinan Waladwadi, Said Al-Ismaily, Buthaina Al-Siyabi

“…This study demonstrated that soil salinity is a strong regulator of soil microbial diversity and function, as reflected by a marked decrease in the responsiveness of soil microbes to various root exudate carbon sources.…”
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Rapid flips between warm and cold extremes in a warming world by Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei

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Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Materials and Methods: This retrospective study included 65 patients (mean age: 51.2 ± 11.5 years; 21 female) with moderate CAD, selected from the Radiological Database of our hospital between May 2022 and December 2024. …”
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Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
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Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage by Ilgiz Gareev, Ozal Beylerli, Elmar Musaev, Chunlei Wang, Valentin Pavlov

“…TargetScan, miRDB, and RNA22 were used to investigate the miRNAs regulating the DEGs. The functional annotation of DEGs was performed using Gene Ontology (GO) resources, and the cell signaling pathway analysis of DEGs was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
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Cloning and expression of a C3H-type zinc finger protein gene BoCCCH2 from Brassica oleracea var. italica by JIANG Ming, LIU Qing’e, ZHANG Yanru, ZHU Qi, GONG Xiu, YU Keke, ZHOU Xiuqian

“…Cloning and expression analysis of BoCCCH2 provide evidence for further studies on gene function.…”
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Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Emerging strategies, such as selective NOX inhibitors, antioxidant therapies, and agents modulating signaling transduction, offer promising avenues for mitigating oxidative injury and improving cardiac function. …”
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Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
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Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis by Peng Zhang, Ruifang Wu, Xiaochao Zhang, Suhan Zhang, Siying Li, Yuwen Su

“…This meta-analysis aims to determine the association between psoriasis and AITD.Design A meta-analysis of observational studies.Data sources PubMed, EMBASE, Scopus and the Cochrane Library were searched up to 1 November 2021.Eligibility criteria for selecting studies We included non-randomised studies, each with over 50 cases in every group, focusing on the rate of comorbidity between psoriasis and AITD.Data extraction and synthesis Two independent reviewers screened the articles and extracted data. …”
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Towards the Question on the Zero Subject in English by I. S. Stepanenko, L. A. Ulianitckaia, T. V. Shulzhenko

“…The examples illustrating the functional features of the implicit subject in English sentence were selected by means of the method of continuous sampling from 7 corpora. …”
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Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness... by Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can

“…The method’s optimization was carried out using the Box-Behnken design, whereas the optimized conditions were selected according to the desirability function. Validation of the method was done with the International Council for Harmonization, ICH Q2(R2) Guidelines. …”
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A systematic literature review of the impact and measurement of mobility impairment in rare bone diseases by Inês Alves, Ingunn Westerheim, Edward C. Hsiao, Jaymin Upadhyay, Luca Sangiorgi, Alexander Artyomenko, Kim Croskery, Juliet Johns, Emma Warnants, Gabor Barton

“…There were 34 functional assessments, 22 questionnaires, and 5 technologies described. …”
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Epidemiological Informing of the Population in Cities: Models and Their Application by Vasiliy Osipov, Marina Osipova, Sergey Kuleshov, Alexandra Zaytseva, Aleksey Aksenov

“…The method is characterized by a new objective function that links economic efficiency with the state of health of the population in an epidemic. …”
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Application Of The Denitrification-Decomposition (DNDC) Model To Retrospective Analysis Of The Carbon Cycle Components In Agrolandscapes Of The Central Forest Zone Of European Russ... by Olga E. Sukhoveeva, Dmitry V. Karelin

“…In growing  season, the agrolandscapes function as a net carbon  sink and accumulate C from the atmosphere  into plant biomass. …”
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