Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
Get full text

DistB-Condo: Distributed Blockchain-Based IoT-SDN Model for Smart Condominium by Anichur Rahman, Md. Jahidul Islam, Ziaur Rahman, Md. Mahfuz Reza, Adnan Anwar, M. A. Parvez Mahmud, Mostofa Kamal Nasir, Rafidah Md. Noor

“…Condominium network refers to intra-organization networks, where smart buildings or apartments are connected and share resources over the network. Secured communication platform or channel has been highlighted as a key requirement for a reliable condominium which can be ensured by the utilization of the advanced techniques and platforms like Software-Defined Network (SDN), Network Function Virtualization (NFV) and Blockchain (BC). …”
Get full text

Composition of the culturable bacterial community associated with the water column and soft tissues from oysters of the mangrove ecosystem at Honda Swamp, Colombian Caribbean by Lersy López Gutiérrez, Martha Torres, Esteban Zarza González, Alejandro Henao Castro, Laura Contreras Vega

“…Microbiological activity is the basis of ecosystems functioning, among these are the mangroves, which offer a wide variety of goods and services to humanity. …”
Get full text

Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Subsequently, the interrelationship between topological metrics and vegetation CUE was analyzed, and optimization strategies were proposed based on the significance of the structure and function. The findings revealed that: (1) Vegetation CUE exhibited a spatially decreasing trend from the western to eastern regions, with spatial patterns correlated with vegetation types, temperature, and precipitation distribution; (2) The ecological spatial network demonstrated a denser configuration in the upper and middle reaches and a sparser and shorter pattern in the lower reaches, with seamless connectivity among all regions; (3) Significant correlations were observed between topological metrics and vegetation CUE, prompting the adoption of ecological construction and protection measures when functional importance is deficient, and enhancing the connectivity of ecological sources through the augmentation of ecological corridors when structural importance is lacking. …”
Get full text

NaCl-induced soil stress regulates the diversity of soil bacteria and their ability to metabolize low molecular weight organic acids by Adhari Al-Kalbani, Daniel Menezes-Blackburn, Jinan Waladwadi, Said Al-Ismaily, Buthaina Al-Siyabi

“…This study demonstrated that soil salinity is a strong regulator of soil microbial diversity and function, as reflected by a marked decrease in the responsiveness of soil microbes to various root exudate carbon sources.…”
Get full text

Boosting Aeroponic System Development with Plasma and High-Efficiency Tools: AI and IoT—A Review by Waqar Ahmed Qureshi, Jianmin Gao, Osama Elsherbiny, Abdallah Harold Mosha, Mazhar Hussain Tunio, Junaid Ahmed Qureshi

“…Sustainable agriculture faces major issues with resource efficiency, nutrient distribution, and plant health. …”
Get full text

Seropositivity of Brucella spp. and Leptospira spp. antibodies among abattoir workers and meat vendors in the city of Mwanza, Tanzania: A call for one health approach control strat... by Mariam M Mirambo, Georgies F Mgode, Zakaria O Malima, Matata John, Elifuraha B Mngumi, Ginethon G Mhamphi, Stephen E Mshana

“…<h4>Introduction</h4>Brucellosis and leptospirosis are among neglected tropical zoonotic diseases particularly in the resource limited countries. Despite being endemic in these countries, there is paucity of information on its magnitude. …”
Get full text

Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Materials and Methods: This retrospective study included 65 patients (mean age: 51.2 ± 11.5 years; 21 female) with moderate CAD, selected from the Radiological Database of our hospital between May 2022 and December 2024. …”
Get full text

Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
Get full text

Personality and Personality Disorders in Medication-Overuse Headache: A Controlled Study by SWAP-200 by Federica Galli, Annalisa Tanzilli, Alessandra Simonelli, Cristina Tassorelli, Grazia Sances, Micol Parolin, Patrizia Cristofalo, Ivan Gualco, Vittorio Lingiardi

“…At levels of specific PDs, MOH patients showed higher obsessive and dysphoric traits and better overall psychological functioning than SUD and PD patients. Conclusion. Although MOH, SUD, and PD populations have been evaluated in multiple sites with different levels of expertise, the study supported the presence of a specific constellation of personality in MOH patients including obsessive (perfectionist) and dysphoric characteristics, as well as good enough psychological resources. …”
Get full text

Predicting the course of localized periodontitis of traumatic etiology after complex treatment by Aleksandra V. Smirnova, Diana A. Kuzmina, Natalia A. Sokolovich, Ekaterina S. Mikhailova, Svetlana V. Sverdlova, Ivan V. Grigoriev

“…To assess the body’s adaptive resources, the entropy of the leukocyte blood count was calculated, and risk factors for the occurrence of LPT were assessed. …”
Get full text

Impacts of Mechanical Injury on Volatile Emission Rate and Composition in 45 Subtropical Woody Broad-Leaved Storage and Non-Storage Emitters by Yali Yuan, Yimiao Mao, Hao Yuan, Ming Guo, Guomo Zhou, Ülo Niinemets, Zhihong Sun

Get full text

Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces by Wenjing Lu, Biqing Zha, Jie Lyu, Chenxi LingHu, Jing Chen, Sisi Deng, Xiangling Zhang, Liang Li, Guoqing Wang

“…Two annotated regions of secondary metabolite biosynthesis genes, both belonging to Terpene, were detected using the antiSMASH online tool.ConclusionThese findings indicate that the four Akkermansia isolates, which belong to a phylogroup distinct from the model strain DSM 22959, exhibit lower genetic risk and may serve as potential probiotic resources for future research.…”
Get full text

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Emerging strategies, such as selective NOX inhibitors, antioxidant therapies, and agents modulating signaling transduction, offer promising avenues for mitigating oxidative injury and improving cardiac function. …”
Get full text

Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
Get full text

Dissecting the genetic basis of response to salmonid alphavirus in Atlantic salmon by Domniki Manousi, Dorota Monika Jaskula, Fabian Grammes, Tim Martin Knutsen, Shahmir Naseer, Samuel AM Martin, Thomas Moen, Marie Saitou, Sigbjørn Lien

“…Additionally, another QTL on Ssa07 was detected, linked to infection-specific response. Transcriptomics analysis of the genes overlapping the Ssa03 QTL region revealed significant expression differences among three tandemly duplicated gig1-like genes, whereas allele-specific expression analysis detected several SNPs with putative functional impact on the particular genes. …”
Get full text

Identification of novel angiotensin I-converting enzyme inhibitory peptides from walnut (Juglans sigillata Dode) protein hydrolysates and their vascular endothelial protective prop... by Wenyun Xiong, Lixia Guo, Yiting Zhang, Shurui Li, Zihuan Wu, Shengbao Cai

Get full text

Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis by Peng Zhang, Ruifang Wu, Xiaochao Zhang, Suhan Zhang, Siying Li, Yuwen Su

“…This meta-analysis aims to determine the association between psoriasis and AITD.Design A meta-analysis of observational studies.Data sources PubMed, EMBASE, Scopus and the Cochrane Library were searched up to 1 November 2021.Eligibility criteria for selecting studies We included non-randomised studies, each with over 50 cases in every group, focusing on the rate of comorbidity between psoriasis and AITD.Data extraction and synthesis Two independent reviewers screened the articles and extracted data. …”
Get full text

Towards the Question on the Zero Subject in English by I. S. Stepanenko, L. A. Ulianitckaia, T. V. Shulzhenko

“…The examples illustrating the functional features of the implicit subject in English sentence were selected by means of the method of continuous sampling from 7 corpora. …”
Get full text

Chemometrically assisted optimization and validation of the HPLC method for the analysis of alectinib and its related impurity with measurement uncertainty evaluation and whiteness... by Serkan Levent, Abeer Elriş, Hazal Avcı, Saniye Özcan, Nafiz Öncü Can

“…The method’s optimization was carried out using the Box-Behnken design, whereas the optimized conditions were selected according to the desirability function. Validation of the method was done with the International Council for Harmonization, ICH Q2(R2) Guidelines. …”
Get full text