Targeting Amyloid Pathology in Early Alzheimer’s: The Promise of Donanemab-Azbt by Nadia Khartabil, Ayda Awaness

“…It specifically targets and reduces amyloid beta plaques, a hallmark of the disease, potentially slowing progression and preserving cognitive function. However, its administration requires careful patient selection, including genetic testing for ApoE ε4 status, to mitigate risks of ARIA. …”
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Assessing chronic obstructive pulmonary disease risk based on exhalation and cough sounds by Geyi Wen, Chenshuo Wang, Wei Zhao, Jinliang Meng, Yanyan Xu, Ruiqi Wang, Zijing Zeng

“…This approach is not only feasible and practical for real-world applications, but also offers an affordable and accessible solution, especially beneficial in resource-limited settings.…”
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How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia? by D. K. Zhogolev, S. N. Bondarenko, A. G. Smirnova, Yu. Yu. Vlasova, D. A. Chernyshova, I. S. Moiseev, A. D. Kulagin

“…Optimizing transplantation strategies, including the selection of the graft source and modification of conditioning regimens, may improve haplo‑HSCT outcomes.   …”
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Photonics-Aided THz Integrated Sensing and Communication System Based on a Subcarrier-Chirp Inter-Embedded Waveform by Junhao Zhang, Mingzheng Lei, Min Zhu, Qingzhi Zhou, Bingchang Hua, Yuancheng Cai, Hao Li, Jiao Zhang, Zhengyi Liang, Yang Li, Xingyu Chen, Junjie Ding, Qing Zhong, Sha Zhu, Jianjun Yu

“…By fully utilizing the idle time-frequency resources of the LFMCW, a density of information-resolution quotient of up to 46.2 × 10-2 bit·s/m2 has been achieved. …”
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Adaptive conflict resolution for IoT transactions: A reinforcement learning-based hybrid validation protocol by Mohammad A. Al Khaldy, Ahmad Nabot, Ahmad al-Qerem, Issam Jebreen, Abdulbasit A. Darem, Asma A. Alhashmi, Mohammad Alauthman, Amjad Aldweesh

“…The RL-based mechanism continuously adapts decision-making by learning from system states, prioritizing transactions, and dynamically resolving conflicts using a reward function that accounts for key performance parameters, including the number of conflicting transactions, cost of aborting transactions, temporal validity constraints, and system resource utilization. …”
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Application of microscopic smartphone attachment for remote preoperative lab testing by Kefan Song, Kefan Song, Alexander T. Adams, Alexander T. Adams

“…This device is designed to assist both healthcare providers in resource-limited settings and patients by offering a low-cost, portable diagnostic tool that enables both in-clinic and at-home testing.MethodsThe system was tested for adaptability and compatibility by transitioning from its original Android platform to an iOS platform. …”
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Exploring the Medicinal Potential of <i>Taraxacum Kok-Saghyz</i> (<i>TKS</i>) Using Widely Targeted Metabolomics by Michele Tan, Jeffrey Shih-Chieh Chu, Daniel Robin Swiger

“…This study presents the first comprehensive metabolic profile of <i>TKS</i>, highlighting its potential value beyond rubber production. The detection of numerous therapeutic secondary metabolites supports its promise as a pharmaceutical and nutraceutical resource. …”
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Effects of Covid-19 Pandemic on School Dropout in Selected Primry Schools in Nyarusiza Sub-County Kisoro District. by Sibo, Dusabe Chris Jackson

“…Innovative approaches could be used such as applications of artificial intelligence in high-risk/high-traffic sites to enhance COVID-19 detection efficiency while protecting medical staff and the general public from cross-infections The government should establish a physical and automated platform for coordination and resource mobilization for support to the poor pupils and the most vulnerable groups affected by COVID-19-related lockdown.…”
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Precision medicine in premature ovarian insufficiency: a focus on the precision therapeutic strategies for mesenchymal stem cells by Rou Wang, Fengyuan Liu, Qiuyue Liao, Jiachen Wu, Lingjuan Wang, Kezhen Li

“…Key issues include the selection of appropriate MSCs sources, the optimization of culture conditions, and the determination of optimal transplantation protocols (encompassing dosage, administration route, and timing), all of which pose significant barriers to clinical translation of MSCs. …”
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Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens by Lianlian Zhao, Xiaolin Ding, Li Zhou, Chenchen Song, Taisheng Kang, Yanfeng Xu, Yunpeng Liu, Yunlin Han, Wenjie Zhao, Boxiang Zhang, Dan Xu, Jianguo Guo

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Epigenome-wide DNA methylation analysis reveals differentially methylation patterns in skeletal muscle between Chinese Chenghua and Qingyu pigs by Kai WANG, Ping-xian WU, Shu-jie WANG, Xiang JI, Dong CHEN, An-an JIANG, Wei-hang XIAO, Yan-zhi JIANG, Li ZHU, Yang-shuang ZENG, Xu XU, Xiao-tian QIU, Ming-zhou LI, Xue-wei LI, Guo-qing TANG

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Early Fault-Tolerant Quantum Algorithms in Practice: Application to Ground-State Energy Estimation by Oriel Kiss, Utkarsh Azad, Borja Requena, Alessandro Roggero, David Wakeham, Juan Miguel Arrazola

“…Additionally, we provide quantitative resource estimates, demonstrating a constant factor improvement in the number of samples required to detect a specified change in CDF. …”
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FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction by Clarissa Tacto, Meghan Tahbaz, Andrew Salib, Shudi Wang, Fritz Cayabyab, Jinhyuk Choi, Kiyoka Kim, Yu Hamba, Harvey Perez, Paul D. Gershon, Robert Damoiseaux, Tae Gyu Oh, Eiji Yoshihara

“…These results suggest that FXYD2 marks and regulates human β cell maturation via channel-sensing signal transduction and that it can be used as a selection marker for functional heterogeneity of stem cell derived human islet organoids.…”
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Genotyping from targeted NGS data based on a small set of SNPs correctly matches patient samples by Deyan Yordanov Yosifov, Christof Schneider, Stephan Stilgenbauer, Daniel Mertens, Eugen Tausch

“…In two cohorts of totally 1441 patients with sequential samples, we could identify 3 sample swaps, 7 mislabelled samples (3 externally and 4 internally) and 1 mistake of unknown origin. We provide an R function for automated detection of sample swaps and mislabelling to the community as a free and open-source tool.…”
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A Comparison of Feminist Term Translation Practices in Academic Journals of Gender and Women’s Studies in Turkiye by Göksenin Abdal, Tuba Ayık Akça

“…Feminist term translation brings both linguistic and pragmatic sides of translation together and turns the act of translation into a function-driven process rather than a solely form-based transfer. …”
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The methodology of translating the metonymic images of the Resurrection in the Holy Qur’an according to Larson’s theory, the translation of Makarim Al-Shirazi and Hussain Ansaryan... by Hossein Bayat, Ali Zeighami, Sayyed Reza Mirahmadi, Ebrahim Rezapour

“…His semantic translation is a faithful translation into the source language and a reliable way to translate texts, especially religious texts. …”
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Dynamic and efficient vehicular cloud management scheme with privacy protection by Min XIAO, Tao YAO, Yuanni LIU, Yonghong HUANG

“…The vehicular cloud (VC) formed by vehicles is used for localization processing and consumption of traffic sensing data to achieve timely intelligent traffic management.The vehicle cloud is highly dynamic, self-organizing and timely, in which the identity and location privacy of vehicle users need to be protected as this poses challenges to the vehicular cloud management.A dynamic and self-organizing vehicle cloud management scheme based on the asymmetric group key agreement protocol was designed, where the vehicle cloud is automatically formed through the self-organized group key agreement of vehicles.The group key was used to control the provision and access of vehicle cloud services, and the dynamic management of the vehicle cloud was implemented through group key update.The scheme used traceable one-time pseudonym technology to achieve anonymous authentication and conditional privacy protection of vehicle users, and the group key agreement stage only included one bilinear pair operation to achieve high efficiency.In addition, the key negotiation and update process used lightweight signatures, supporting batch verification, to achieve efficient message source authentication and integrity authentication.Then the security and efficiency of vehicle cloud communications in the self-organizing environment can be ensured.The dynamic key update mechanism of the key agreement protocol realized the dynamic joining or exiting of vehicles in the vehicle cloud, adapting to the dynamic characteristics of the vehicle cloud.Under the random oracle model and the difficult assumption of the inverse computational Diffie Hellman (ICDH) problem, it was proved that the asymmetric group key agreement scheme satisfied the selective-plaintext security.The security analysis shows that the scheme can protect the identity and location privacy of vehicle users, realize the legal tracking of malicious vehicles, and ensure the confidentiality, integrity and anti-counterfeiting of communications, as well as the forward security of vehicle cloud dynamic management.The performance comparison analysis shows that this scheme has certain advantages in communication and computing efficiency under the condition of the same function and security level.…”
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A directed greybox fuzzer for windows applications by Xin Ren, Peng-fei Wang, Xu Zhou, Kai Lu

“…Abstract Directed greybox fuzzing (DGF) has proven effective in vulnerability discovery, but most efforts focus on the Linux platform, with substantially less attention devoted to Windows platform due to its closed-source and GUI software nature. This paper proposes WinDGF, a novel directed greybox fuzzer for Windows applications that addresses challenges including target function localization in persistent testing, GUI bypassing, and fitness metric calculation. …”
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CHARTER OF THE STAVROPOL KRAI: PROBLEM ISSUES AND SEARCH FOR SOLUTION by V. Cherepanov

“…The interpretation of the source of the government of the Stavropol Krai, which is the people of the Stavropol Kraias part of the multinational people of the Russian Federation, has been proposed. …”
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Prevalence and determinants of restrictive lung disorder among quarry workers at the Umuoghara quarry site, Ebonyi State, Nigeria: a cross-sectional study by Ngozika Substance Ike-Samuel, Osaeloka C. Ekwueme, Susan Chioma Udeh

“…Data was collected using a pre-tested semi-structured questionnaire among 300 quarry workers selected by simple random sampling method. Lung function test was performed using a spirometer- spirovit SPI schiller and data was analyzed with the use of IBM SPSS version 23.0. …”
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