Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…A contrasting pattern was detected for the gene expression of cytochrome c oxidase subunit 4I1 (COX4I1), with stable levels in CON and a downregulation in CAR due to LPS injection. …”
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Linking soil microbial genomic features to forest-to-pasture conversion in the Amazon by Andressa M. Venturini, Júlia B. Gontijo, Louis Berrios, Jorge L. Mazza Rodrigues, Kabir G. Peay, Siu M. Tsai

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Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins by Ruolan Yi, Jiaoyang Zheng, Zhichao Xu, Jiayan Wu, Fangfang Liu, Jinxin Zheng, Duoyun Li, Shiqing Han, Zhijian Yu

“…Additionally, while the growth adaptation of K2044−8Xyl−60G under xylose pressure was confirmed, no amino acid mutations were detected in the functional proteins of this xylose-induced isolate, suggesting that persistent xylose pressure does not cause nonsense mutations in the bacterial genome. …”
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Myo-inositol affects the health, metabolome, and lactation performance of peripartum dairy cows by Chun-zheng Wang, Jia-nan Dong, Jia-nan Dong, Wu-wen Sun, Wu-wen Sun, Ke Qu, Zi-chen Lin, Natnael D. Aschalew, Natnael D. Aschalew, Yang Zhao, Zhe Sun, Zhe Sun, Zhe Sun, Na Ta, Zhi-kun Zhao, Yong-jun Liu, Yong-jun Liu, Wei-gang Zhang, Wei Zhao, Gui-xin Qin, Yu-guo Zhen, Yu-guo Zhen, Tao Wang, Tao Wang

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PA-Win2: In Silico-Based Discovery of a Novel Peptide with Dual Antibacterial and Anti-Biofilm Activity by Jin Wook Oh, Min Kyoung Shin, Hye-Ran Park, Sejun Kim, Byungjo Lee, Jung Sun Yoo, Won-Jae Chi, Jung-Suk Sung

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A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study by Kayla V Taylor, Laurent Garchitorena, Carolina Scaramutti-Gladfelter, Mykayla Wyrick, Katherine B Grill, Azizi A Seixas

“…Finally, phase 4 will include a year-long pre- and posttest pilot study to rigorously evaluate the usability and effectiveness of Neolth in addressing the mental health concerns of students across the selected schools. ResultsPhase 1 was successfully completed in August 2022, revealing significant deficits in mental health resources within the participating schools. …”
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Thermophilic microbial agents promote the fermentation progression of spent mushroom compost and pig manure by Hongbo Du, Chongchong Lu, Muhanmad Zunair Latif, Jianfeng Du, Yong Liu, Hongxin Li, Xinhua Ding

“…Overall, the application of thermophilic microbial agents not only extended the high temperature phase of composting by over 30% and shortened the composting cycle by 50%, but more importantly, it achieved comprehensive improvement in compost quality by selectively enriching functional microbial communities such as Pseudomonas. …”
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The anti-aging potential of antihypertensive peptides of Pariset, a dataset of algal peptides by Isaac Karimi, Parisa Olfati, Layth Jasim Mohammed, Jawad Kadhim Tarrad, Ahmed M. Amshawee, Maryam A. Hussain, Helgi B. Schiöth

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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…Consequently, there is the demand for the development of individual educational  programmes and modules, freedom of access for students to new resources and technologies, change of functions and competencies of pedagogical workers.The conclusion is drawn that the assessment of own competitiveness acts as the defining factor of the relation to the chosen field of occupation. …”
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Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1 by Zhiyue Qiu, Shirui Wen, Hong Yuan, Ziyi Liu, Yao Wei, Siqi Yanling, Runlong Dai, Xiang Li, Yuxin Gu

“…Finally, some improvement strategies are put forward, such as optimizing the network layout, building multi-level centers, strengthening functional connections, and enhancing the development intensity. …”
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Geographer Harm J. de Blij: Academic Contributions and Scientific Communication in Geography by Tang Maolin

“…Most political geography books at the time were dominated by chapters describing the circumstances of selected world regions or reviews of different attributes of states, such as population, resources, and environment. …”
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THBS1 is a new autosomal recessive non-syndromic hearing impairment gene by Thashi Bharadwaj, Anushree Acharya, Fati Ullah Khan, Saadullah Khan, Irfan Ullah, Isabelle Schrauwen, Wasim Ahmad, Suzanne M. Leal

“…Using Sanger sequencing select variants were validated and tested for segregation using DNA samples from additional family members. …”
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Untargeted metabolomics reveals stage-specific metabolic signatures in yak colostrum, transitional milk and mature milk by Yunduan Wang, Daoliang Lan, Shaohui Beng, Shunyang Liu, Xueer Mu, Kechao Chen, Yueyue Li, Meng Xu, Jian Li, Wei Fu

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Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Vegetation, as a crucial carbon sink, is facing extensive degradation under the mounting pressures of urbanization and excessive resource exploitation, exacerbating the imbalance between carbon sources and sinks. …”
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Clinical and economic effectiveness of Schroth therapy in adolescent idiopathic scoliosis: insights from a machine learning- and active learning-based real-world study by Erdal Ayvaz, Merve Uca, Ednan Ayvaz, Zafer Yıldız

“…Results Exercise-based therapy resulted in a mean Cobb angle reduction of 6.8° (SD = 3.1), with significant improvements in pain and function (p < 0.001). The ICER was estimated at $1,730 per additional degree of Cobb angle correction, with a projected QALY gain of 0.03 per patient. …”
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Analysis of random factors of the self-education process by A. A. Solodov

“…These numbers are interpreted as a resource (price), which is consumed with the appearance of each event and are mapped to external factors selflearning process.For each private model provided optimal algorithms for estimating the relevant factors according to selected criteria, in the simplest cases, the analytical expressions are indicated. …”
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Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation by Jingyi Hou, Jingyi Hou, Jingyi Hou, Lihan Wang, Lihan Wang, Naiqiang Zhu, Xueli Li

“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects by Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge, Navnath S. Gavande

“…Particular attention is given to the role of USP inhibitors in enhancing cancer immunotherapy, e.g., modulation of the tumor microenvironment, effect on regulatory T cell function, and influence on immune checkpoint pathways. …”
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Palm-size wireless piezoelectric immune-biosensing system for rapid E. coli O157:H7 detection by Yang Tian, Lisa Kelso, Yiting Xiao, Chaitanya Pallerla, Ramesh Bist, Siavash Mahmoudi, Ziyu Liu, Haizheng Xiong, Jeyam Subbiah, Terry Howell, Dongyi Wang

“…The system integrates a gold-coated quartz crystal microbalance (QCM) sensor functionalized with protein A-immobilized antibodies, a polydimethylsiloxane (PDMS) microfluidic channel for efficient sample handling, and a flexible loop antenna for wireless signal transmission. …”
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Association of Omega-3 Index and Blood Cell Count-Derived Systemic Inflammatory Indexes among Testicular Germ Cell Tumor Survivors by Milica Zeković, Marko Živković, Marija Takić, Sanja Stanković, Nebojša Bojanić, Aleksandar Janičić, Uroš Bumbaširević

“…Background and objectives: Although testicular cancer is considered the paradigm of highly curable malignancy, treatment-induced adverse effects and potential impairment of gonadal function may cause non-negligible long-term health repercussions, including metabolic disturbances and cardiovascular sequelae. …”
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