The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis by Lu Zhao, Xin Chen, Yanan Zhang, Yixuan Cen, Tingjia Zhu, Lingfang Wang, Lili Xia, Yang Li, Xiaodong Cheng, Xing Xie, Weiguo Lu, Junfen Xu

“…Mechanistically, circPOLD1 functioned as an oncogene by binding to and phosphorylating YBX1, activating the AKT/mTOR/HIF-1α pathway to enhance glycolysis-driven tumorigenesis. …”
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Gallium oxide (Ga2O3) as a radiation detector distinguishing neutrons and gammas by D. J. Valdes, L. Rendon, J. Winkelbauer, P. Koehler, S. C. Vogel, K.-X. Sun

“…Gallium oxide (Ga2O3) is a promising ultrawide bandgap semiconductor for radiation detection with the potential of integrating electronic and scintillation functions within a single crystal device. …”
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Bearing Small Sample Fault Diagnosis based on Data Generation and Transfer Learning by Dinghui Wu, Qin Fang, Chuyi Wu

“…First， the source dataset is trained on the training network to obtain the source model， and then a small amount of drive-end data is used as the target dataset to fine-tuning to obtain the target model. …”
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Incorporating Non-Coding Annotations into Rare Variant Analysis. by Tom G Richardson, Colin Campbell, Nicholas J Timpson, Tom R Gaunt

“…<h4>Methods & results</h4>We conducted a candidate gene analysis using the UK10K sequence and lipids data, filtering according to functional annotations using the resource CADD (Combined Annotation-Dependent Depletion) and contrasting results with 'nonsynonymous' and 'loss of function' consequence analyses. …”
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Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. by Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark

“…Furthermore, Ubx binding was detected at known Polycomb response elements (PREs) and was associated with significant enrichments of Pc and Pho ChIP signals in contrast to binding sites of other developmental TFs. …”
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Origami-Inspired Biosensors: Exploring Diverse Applications and Techniques for Shape-Changing Sensor Platforms by Shikha Patil, Shariq Suleman, Nigar Anzar, Jagriti Narang, Roberto Pilloton, Suna Timur, Emine Guler Celik, Chandra S. Pundir, Sudheesh K. Shukla

“…Paper and biological substrates like DNA have been integrated with origami techniques to develop biosensors with enhanced functionality. The incorporation of aptamer origami into both paper and DNA biosensors further increases sensitivity and specificity for target detection. …”
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Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. by Takeshi Matsui, Ian M Ehrenreich

“…To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two budding yeast strains. This phenotype is detectable when certain segregants are grown on ethanol at 37°C ('E37'), a condition that differs from the standard culturing environment in both its carbon source (ethanol as opposed to glucose) and temperature (37°C as opposed to 30°C). …”
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Application of microscopic smartphone attachment for remote preoperative lab testing by Kefan Song, Kefan Song, Alexander T. Adams, Alexander T. Adams

“…This device is designed to assist both healthcare providers in resource-limited settings and patients by offering a low-cost, portable diagnostic tool that enables both in-clinic and at-home testing.MethodsThe system was tested for adaptability and compatibility by transitioning from its original Android platform to an iOS platform. …”
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Exploring the Medicinal Potential of <i>Taraxacum Kok-Saghyz</i> (<i>TKS</i>) Using Widely Targeted Metabolomics by Michele Tan, Jeffrey Shih-Chieh Chu, Daniel Robin Swiger

“…This study presents the first comprehensive metabolic profile of <i>TKS</i>, highlighting its potential value beyond rubber production. The detection of numerous therapeutic secondary metabolites supports its promise as a pharmaceutical and nutraceutical resource. …”
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Effects of Covid-19 Pandemic on School Dropout in Selected Primry Schools in Nyarusiza Sub-County Kisoro District. by Sibo, Dusabe Chris Jackson

“…Innovative approaches could be used such as applications of artificial intelligence in high-risk/high-traffic sites to enhance COVID-19 detection efficiency while protecting medical staff and the general public from cross-infections The government should establish a physical and automated platform for coordination and resource mobilization for support to the poor pupils and the most vulnerable groups affected by COVID-19-related lockdown.…”
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GENERATION AND COLLECTION OF TOBACCO AEROSOL FOR SHISHA by N. N. Bubnova, M. V. Shkidyuk

“…Qualitative characteristics of tobacco aerosol for shisha are determined by the functional purpose and depend on the component composition of the tobacco mixture and the coal used.The purpose of the research is to develop a methodology for the comprehensive assessment of tobacco for shisha based on modern methods of product quality control and includes the following steps:- monitoring of the studies to determine the component composition of the hookah mixture and the aerosol produced;- analysis of hookah mixture testing modes and development of an aerosol generation protocol;- development of a method for collecting aerosol on a laboratory smoking machine; - quantitative analysis of toxic analytes by HPLC MS / MS method.Methods have been developed for the machine generation and collection of tobacco aerosol for hookah, taking into account low concentrations of the analyzed toxic substances.The expediency of using the HPLC MS / MS method to determine the quantity of the following substances in tobacco aerosol for shisha has been substantiated:- carbonyl compounds (formaldehyde, acetaldehyde, acrolein) by detection on an electrospray source in the negative polarity mode- tobacco specific nitrosoamines (NNN and NNK) by detection on an electrospray source in the positive polarity mode.During the research laboratory and analytical equipment was used: a five-channel linear CERULEAN SM 405 smoking machine; Thermo Scientific Dionex UltiMate 3000 liquid chromatograph and TSQ Quantiva mass spectrometer.Obtaining experimental data on the quantitative determination of the component composition of the aerosol produced by tobacco for shisha using hookah systems is relevant for assessing toxic characteristics of the product.…”
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Testing infrared camera surveys and distance analyses to estimate feral horse abundance in a known population by Kathryn A. Schoenecker, Paul F. Doherty Jr., Jacob S. Hourt, John P. Romero

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Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-di... by Rui Wang, Jessie P. Bakker, Ronald D. Chervin, Susan L. Garetz, Fauziya Hassan, Stacey L. Ishman, Ron B. Mitchell, Michael G. Morrical, Syed K. Naqvi, Jerilynn Radcliffe, Emily I. Riggan, Carol L. Rosen, Kristie Ross, Michael Rueschman, Ignacio E. Tapia, H. Gerry Taylor, David A. Zopf

“…The study’s coprimary endpoints are (1) change from baseline in executive behaviour relating to self-regulation and organisation skills as measured by the Behavioural Rating Inventory of Executive Function (BRIEF) Global Composite Score (GEC); and (2) change from baseline in vigilance as measured on the Go-No-Go (GNG) signal detection parameter (d-prime). …”
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Investigating the AGN-neutrino connection with public IceCube data by Kuhlmann Julian, Capel Francesca

“…We present the first application of a newly developed hierarchical Bayesian analysis framework for the detection of point-like sources of high-energy neutrinos. …”
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Intra action review of the cholera outbreak response in Kadoma city, Zimbabwe, 2024 by Clayton Munemo, Chido Zibanayi, Hamilton Gomba, Precious Banda, Sarah Tengawarima, Sikhanyisiwe Moyo, Daniel Chirundu

“…The working groups covered eight response pillars aligned to the five core functions of the Incident Management System (IMS). …”
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On the usage of artificial intelligence in leprosy care: A systematic literature review. by Hilson Gomes Vilar de Andrade, Elisson da Silva Rocha, Kayo H de Carvalho Monteiro, Cleber Matos de Morais, Danielle Christine Moura Dos Santos, Dimas Cassimiro Nascimento, Raphael A Dourado, Theo Lynn, Patricia Takako Endo

“…The persistent stigma and social exclusion associated with leprosy complicate eradication efforts exacerbate the wider challenges faced by NTDs in sourcing the necessary resources and attention for control and elimination. …”
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Ferro-aluminosilicate composite generated from coal gasification fine slag for the preconcentration and adsorptive removal of selected artificial sweeteners from water by Xoliswa Cingo, Azile Nqombolo, Buhle Xakalashe, Xolisa Goso, Luthando Nyaba, Odwa Mapazi, Philiswa Nosizo Nomngongo

“…Furthermore, converting CGFS into functional adsorbents aligns seamlessly with the principles of a circular economy, emphasising resource reutilization and sustainability. …”
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Ultra-high-energy γ-ray emission associated with the tail of a bow-shock pulsar wind nebula

“…The source energy spectrum extended up to 300 TeV, which was well fitted by a log-parabola function with N0 = (1.93 ± 0.23) × 10−16 TeV−1 cm−2 s−1, α = 2.14 ± 0.27, and β = 1.20 ± 0.41 at E0 = 30 TeV. …”
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Chromosome-level genome assembly of starry flounder (Platichthys stellatus) by Weiwei Zheng, Changlin Liu, Shenglei Han, Tengteng Wang, Tao Yang, Zhihong Liu, Dong Xu, Huizong Han, Xiaoqing Xi, Changwei Shao, Kaiqiang Liu

“…Approximately 94.02% of assembled sequences were anchored into 24 pseudochromosomes, and a total of 18 telomeres were detected. Totally 22,835 protein-coding genes and 227.87 Mb repetitive sequences were identified. …”
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Growth and Form Trait Variation Analysis Among Different Clones of Michelia chapensis by Zhixi DENG, Baishuan LYU, Rong HUANG, Limin ZHOU, Runhui WANG, Li CHEN, Zhijun LAI, Jiaqi CHEN, Jie ZHU, Ruping WEI, Huiquan ZHENG

“…Significant (P < 0.05) to highly significant (P < 0.01) phenotypic and genetic correlations were detected among the traits (except between tree height and crown-to-diameter ratio). …”
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