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2161
Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing
Published 2025-06-01“…The target bacterial isolate was detected in medfly when inoculated with liquid diet regardless of age, but those fed a slurry-based diet and a separate water source had less establishment. …”
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2162
Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection
Published 2025-08-01“…ABSTRACT Tuberculosis (TB) stages depend greatly on the interaction between Mycobacterium tuberculosis (Mtb) and the host response. As a non-negligible source of active tuberculosis (ATB), individuals with latent Mtb infection (LTBI) are insidious and hard to be detected due to limited biomarkers. …”
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Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation
Published 2025-01-01“…BackgroundActive dietary flavonoids are a promising resource for novel drug discovery. Sweet potato, a widely cultivated functional crop, is abundant in flavonoids. …”
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2164
Epidemiology of Disability of Adult Population in the Russian Federation
Published 2019-11-01“…In one elderly patient older than 60 years, on average, four to five different chronic diseases are detected. The accumulation of impaired functions of organs and systems helps to reduce the adaptive capacity of the body and is associated with limited life, which entails an increase in the risks of disability in the elderly and the need for medical and social rehabilitation. …”
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2165
Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov...
Published 2025-07-01“…A contrasting pattern was detected for the gene expression of cytochrome c oxidase subunit 4I1 (COX4I1), with stable levels in CON and a downregulation in CAR due to LPS injection. …”
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2166
Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins
Published 2025-04-01“…Additionally, while the growth adaptation of K2044−8Xyl−60G under xylose pressure was confirmed, no amino acid mutations were detected in the functional proteins of this xylose-induced isolate, suggesting that persistent xylose pressure does not cause nonsense mutations in the bacterial genome. …”
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Deep Learning Approaches for Morphological Classification of Intestinal Organoids
Published 2025-01-01“…Rather, SVM and RF performed significantly worse, showing an accuracy approximately 20% lower than the selected DL models. Considering efficiency, ViT had the highest accuracy but required more resources (0.0437 sec/image, 343 MB), while MobileNet, the lightest model (35.6 MB), had the fastest inference time (0.0063 sec/image). …”
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2170
Prostruc: an open-source tool for 3D structure prediction using homology modeling
Published 2024-11-01“…IntroductionHomology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. …”
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Towards developing new private sector maternity care models in South Africa: results from a deliberative stakeholder dialogue
Published 2025-08-01“…Improving equity and outcomes requires leveraging private sector resources, but only if quality issues are addressed. …”
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Isolation of a novel manganese-oxidizing bacterium Lysinibacillus xylanilyticus M125: characterization, structural evolution, and Cd-adsorption activity of biogenic Mn oxides produ...
Published 2025-08-01“…Over 99.5% of cadmium ions in water are adsorbed and removed by strain M125, highlighting its potential for cadmium pollution remediation.DiscussionOverall, this work introduces a new bacterial resource for Mn and Cd bioremediation and offers detailed insights into the structural and functional characteristics of BioMnOx, supporting its application in environmental biotechnology.…”
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2178
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation
Published 2025-05-01“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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2179
NDVI estimation using Sentinel-1 data over wheat fields in a semiarid Mediterranean region
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