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Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
Published 2025-06-01“…Highlighting lactylation's multifaceted roles in health and disease, this review provides a timely resource for understanding its clinical implications, particularly as a novel target for precision medicine in metabolic and oncological therapies.…”
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942
A Novel Approach to Cognitive Load Measurement in N-Back Tasks Using Wearable Sensors, Empirical Mode Decomposition With Machine Learning, and Explainable AI for Feature Importance
Published 2025-01-01“…This study introduces a novel approach for detecting mental workload and stress, utilizing ECG and Fingertip-PPG data from the MAUS dataset. …”
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943
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944
IGFBP7 promotes the proliferation and differentiation of primary myoblasts and intramuscular preadipocytes in chicken
Published 2024-12-01“…We then examined the expression patterns of IGFBP7 across different stages of proliferation and differentiation in CPMs and intramuscular preadipocytes via qPCR, and explored the biological functions of IGFBP7 through gain- and loss-of-function experiments and a range of techniques including qPCR, CCK-8, EdU, flow cytometry, Western blot, immunofluorescence, and Oil Red O staining to detect the proliferation, differentiation, and lipid deposition in CPMs and intramuscular preadipocytes. …”
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945
Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics
Published 2025-06-01“…In this work, miRNA-21 was selectively detected using a complementary DNA probe modified with methylene blue, as a redox mediator, immobilized onto an AuNPs-functionalized, paper-based screen-printed electrode. …”
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946
Efficient analysis of drug interactions in liver injury: a retrospective study leveraging natural language processing and machine learning
Published 2024-12-01“…Electronic medical records contain comprehensive clinical information and have gained increasing attention as a potential resource for DDI detection. However, a substantial portion of adverse drug reaction (ADR) information is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research. …”
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947
An Observational Study on Pre-natal Diagnosis of Congenital Talipes Equinovarus
Published 2025-07-01“…Future research should assess long-term functional outcomes and optimize pre-natal screening protocols, particularly in resource-limited settings, to ensure comprehensive CTEV management.…”
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948
Proteinuria Ratio and Related Factors İn Type 2 DM Patients: A Hospital-Based Study in Somalia
Published 2025-02-01“…Understanding these factors is crucial for early detection and intervention to prevent kidney damage in this population. …”
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949
A UAV Image Stitching Method for Complex Urban Environments
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950
Generation of Cas9 Knock-In <i>Culex quinquefasciatus</i> Mosquito Cells
Published 2025-01-01“…In comparison to the RNAi-mediated gene silencing of <i>dicer-2</i>, <i>argonaute-2b</i>, and <i>piwi5</i>, our Cas9/sgRNA approach showed an enhanced ability to detect antiviral effects. <b>Conclusions</b>: We propose that this cell line offers a new tool for studying gene function in <i>Cx. quinquefasciatus</i> mosquitoes that avoids the use of RNAi. …”
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951
Risks as an object of internal control: identification and assessment
Published 2021-08-01“…The main purpose of internal control is to ensure timely detection and analysis of business risk, reliability of relevant information, integrity of assets, compliance with regulations, internal policies and procedures, implementation of plans and efficient use of resources. …”
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952
A mmWave JCAS System for Real-Time High-Data Rate Communication and RADAR Sensing
Published 2025-01-01“…The same hardware resources, i.e., an orthogonal frequency-division multiplexing (OFDM) baseband processor and a beam-steering phased array antenna frontend, the same signal waveform and the same frequency channel are used for both sensing and communication. …”
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953
The challenge of triple intestinal parasite infections in immigrants—A call for comprehensive differential diagnosis
Published 2024-11-01“…Implementing multisectoral One Health will improve human, animal, and environmental health globally using limited resources. Abstract Parasitic infections including Schistosoma spp., hookworm, and Strongyloides spp. are commonly co‐existing diseases in underdeveloped countries including South Sudan and Sudan. …”
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954
Spatial distribution characteristics and influencing factors of milk tea stores in Wuhan based on sDNA and OPGD models.
Published 2025-01-01“…We then examined the influencing factors by combining spatial design network analysis, optimal parameters-based geographical detection, and location-based service big data. Our results revealed the following: (1) The spatial distribution of stores was concentrated in areas with high closeness and betweenness centrality, forming a multi-core "northwest-southeast" distribution pattern with significant spatial positive correlation. (2) The stores' spatial pattern was influenced by the road network betweenness and the presence of office buildings, shopping malls, shopping centers, and tourism resources. …”
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955
Standard: human liver-on-a-chip
Published 2025-03-01“…However, the lack of standardized definitions, structural designs, cell sources, model constructions, and functional validations has posed challenges to their widespread translational applications. …”
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956
Energy filtering enables macromolecular MicroED data at sub-atomic resolution
Published 2025-03-01“…While direct electron detection essentially eliminates the read-out noise during MicroED data collection, other sources of noise remain and limit the measurement of faint high-resolution reflections. …”
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957
REVISITING THE ORGANIZATION OF A CLINICAL (MEDICAL) PSYCHOLOGIST WORK AT THE FIRST STAGE OF MEDICAL REHABILITATION IN THE CONDITIONS OF THE INTENSIVE CARE UNIT (ICU) BY THE EXAMPLE...
Published 2025-03-01“…There is currently a pressing need to devise a way of neurophycological diagnostics of higher mental functions which would allow to detect cognitive impairment in patients in the ICU during the first stages of medical rehabilitation taking into account working hours constraints.…”
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Epidemic preparedness and response capacity against infectious disease outbreaks in 186 countries, 2018–2022
Published 2024-11-01“…From the 2022 submissions, 116 (62%) countries reported functional (Level 4 or 5) prevention capacity, 162 (87%) had functional detection capacity, 118 (63%) had functional response capacity, 121 (65%) had functional enabling resources and coordination capacity, and 133 (72%) had functional operational readiness against public health events. …”
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960
Early Fault-Tolerant Quantum Algorithms in Practice: Application to Ground-State Energy Estimation
Published 2025-04-01“…Additionally, we provide quantitative resource estimates, demonstrating a constant factor improvement in the number of samples required to detect a specified change in CDF. …”
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