Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. by Takeshi Matsui, Ian M Ehrenreich

“…To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two budding yeast strains. This phenotype is detectable when certain segregants are grown on ethanol at 37°C ('E37'), a condition that differs from the standard culturing environment in both its carbon source (ethanol as opposed to glucose) and temperature (37°C as opposed to 30°C). …”
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Discovery of Genomic Targets and Therapeutic Candidates for Liver Cancer Using Single-Cell RNA Sequencing and Molecular Docking by Biplab Biswas, Masahiro Sugimoto, Md. Aminul Hoque

“…This study aims to uncover key genomic features, analyze their functional roles, and propose potential therapeutic drugs identified through molecular docking, utilizing single-cell RNA sequencing (scRNA-seq) data from liver cancer studies. …”
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Pyruvate formate lyase regulates fermentation metabolism and virulence of Streptococcus suis by Qingying Fan, Haikun Wang, Shuo Yuan, Yingying Quan, Rishun Li, Li Yi, Aiqing Jia, Yuxin Wang, Yang Wang

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Melatonin: A Novel Indolamine in Oral Health and Disease by V. K. Chava, K. Sirisha

“…Recent studies, by Claustrat et al. (2005), detected few extrapineal sources of melatonin like retina, gastrointestinal tract, and salivary glands. …”
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Gallium oxide (Ga2O3) as a radiation detector distinguishing neutrons and gammas by D. J. Valdes, L. Rendon, J. Winkelbauer, P. Koehler, S. C. Vogel, K.-X. Sun

“…Gallium oxide (Ga2O3) is a promising ultrawide bandgap semiconductor for radiation detection with the potential of integrating electronic and scintillation functions within a single crystal device. …”
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Ethics of Sensor-Based Surveillance of People with Dementia in Clinical Practice by Jacob Lahr, Nicole Schulze, Larissa N. Wüst, Claus Beisbart, Lena C. Bruhin, Marcello Ienca, Tobias Nef, Manuel Trachsel, Stefan Klöppel

“…Sensor-based surveillance technology (SST) is increasingly employed in the care of people with dementia (PwD) in hospitals, nursing homes, and home care. With improved functionality and availability of SST, there will likely be a growing utilization in clinical settings. …”
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Performance of the National Tuberculosis Control Program in the post conflict Liberia. by Kassaye Tekie Desta, T E Masango, Zerish Zethu Nkosi

“…For the performance of tuberculosis laboratory testing, all the 107 functional tuberculosis microscopy centers in Liberia were included. …”
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Diagnosing skin neglected tropical diseases with the aid of digital health tools: A scoping review. by Ewelina Julia Barnowska, Anil Fastenau, Srilekha Penna, Ann-Kristin Bonkass, Sophie Stuetzle, Ricky Janssen

“…Recent developments in digital health have given rise to approaches that could increase access to diagnosis in resource-poor areas affected by skin NTDs. This scoping review provides an overview of current digital health approaches that aim to aid in the diagnosis of skin NTDs and provides an insight into the diverse functionalities of current digital health tools, their feasibility, usability, and the current gaps in research around these digital health approaches. …”
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Assessing the Impact of Covid19-Pandemic on the Household Income in Kamuganguzi Sub-County Kabale District. by Arinda, Redeemer Present

“…Additionally, the government should establish a physical and automated platform for coordination and resource mobilization to support poor students and the most vulnerable groups affected by COVID-19-related lockdowns.…”
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GENERATION AND COLLECTION OF TOBACCO AEROSOL FOR SHISHA by N. N. Bubnova, M. V. Shkidyuk

“…Qualitative characteristics of tobacco aerosol for shisha are determined by the functional purpose and depend on the component composition of the tobacco mixture and the coal used.The purpose of the research is to develop a methodology for the comprehensive assessment of tobacco for shisha based on modern methods of product quality control and includes the following steps:- monitoring of the studies to determine the component composition of the hookah mixture and the aerosol produced;- analysis of hookah mixture testing modes and development of an aerosol generation protocol;- development of a method for collecting aerosol on a laboratory smoking machine; - quantitative analysis of toxic analytes by HPLC MS / MS method.Methods have been developed for the machine generation and collection of tobacco aerosol for hookah, taking into account low concentrations of the analyzed toxic substances.The expediency of using the HPLC MS / MS method to determine the quantity of the following substances in tobacco aerosol for shisha has been substantiated:- carbonyl compounds (formaldehyde, acetaldehyde, acrolein) by detection on an electrospray source in the negative polarity mode- tobacco specific nitrosoamines (NNN and NNK) by detection on an electrospray source in the positive polarity mode.During the research laboratory and analytical equipment was used: a five-channel linear CERULEAN SM 405 smoking machine; Thermo Scientific Dionex UltiMate 3000 liquid chromatograph and TSQ Quantiva mass spectrometer.Obtaining experimental data on the quantitative determination of the component composition of the aerosol produced by tobacco for shisha using hookah systems is relevant for assessing toxic characteristics of the product.…”
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Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer by Xiangru Zheng, Wenjun Li, Xiaoli Li, Qianyi Yao, Luquan Zheng, Rongrong Fan, Ping Bie

“…Bioinformatics analysis was conducted to explore the function of GJB4 in PC cells. Changes in ferroptosis in PC cells following GJB4 downregulation were detected by immunofluorescence staining, transmission electron microscopy, and western blotting.ResultsGJB4 expression was found to be upregulated in PC tissues and positively correlated with patient survival. …”
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Weibull-Type Incubation Period and Time of Exposure Using <i>γ</i>-Divergence by Daisuke Yoneoka, Takayuki Kawashima, Yuta Tanoue, Shuhei Nomura, Akifumi Eguchi

“…Accurately determining the exposure time to an infectious pathogen, together with the corresponding incubation period, is vital for identifying infection sources and implementing targeted public health interventions. …”
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Human disturbance influences occupancy of red deer in Mongolia by Rhiannon R. Henderson, Brittany A. Mosher, Rebecca Watters, Tumursukh Jal, James D. Murdoch

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The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis by Lu Zhao, Xin Chen, Yanan Zhang, Yixuan Cen, Tingjia Zhu, Lingfang Wang, Lili Xia, Yang Li, Xiaodong Cheng, Xing Xie, Weiguo Lu, Junfen Xu

“…Mechanistically, circPOLD1 functioned as an oncogene by binding to and phosphorylating YBX1, activating the AKT/mTOR/HIF-1α pathway to enhance glycolysis-driven tumorigenesis. …”
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Ultra-high-energy γ-ray emission associated with the tail of a bow-shock pulsar wind nebula

“…The source energy spectrum extended up to 300 TeV, which was well fitted by a log-parabola function with N0 = (1.93 ± 0.23) × 10−16 TeV−1 cm−2 s−1, α = 2.14 ± 0.27, and β = 1.20 ± 0.41 at E0 = 30 TeV. …”
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Historical traces in Southern Grevena during Ottoman occupation by Vasileios D. Spanos

“…In particular, attention was paid to the detection of all reports of the settlement, in written sources (published and unpublished), so that all the information concerning each settlement, even the simple reports, become known and accessible to the research and also in order to record all types with which each toponym is found, which also facilitates its etymology (although this identification was not always possible). …”
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Incorporating Non-Coding Annotations into Rare Variant Analysis. by Tom G Richardson, Colin Campbell, Nicholas J Timpson, Tom R Gaunt

“…<h4>Methods & results</h4>We conducted a candidate gene analysis using the UK10K sequence and lipids data, filtering according to functional annotations using the resource CADD (Combined Annotation-Dependent Depletion) and contrasting results with 'nonsynonymous' and 'loss of function' consequence analyses. …”
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Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. by Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark

“…Furthermore, Ubx binding was detected at known Polycomb response elements (PREs) and was associated with significant enrichments of Pc and Pho ChIP signals in contrast to binding sites of other developmental TFs. …”
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Origami-Inspired Biosensors: Exploring Diverse Applications and Techniques for Shape-Changing Sensor Platforms by Shikha Patil, Shariq Suleman, Nigar Anzar, Jagriti Narang, Roberto Pilloton, Suna Timur, Emine Guler Celik, Chandra S. Pundir, Sudheesh K. Shukla

“…Paper and biological substrates like DNA have been integrated with origami techniques to develop biosensors with enhanced functionality. The incorporation of aptamer origami into both paper and DNA biosensors further increases sensitivity and specificity for target detection. …”
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Operational monitoring of acoustic sensor networks by V. A. Boltenkov, G. Kh. M. Al-Jasri

“…Both of them are based on the placement of the test sound source within a network. The signal processing for ASN sensors had to detect the failed element. …”
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