A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network by Owen He, Daoxing Chen, Yimei Li

“…In independent test sets, ReproTox-CMPNN achieved a mean AUC of 0.946, ACC of 0.857 and F1 score of 0.846, surpassing traditional algorithms to establish itself as a new state-of-the-art model in this field. …”
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Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells... by Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng

“…Notably, the expression levels of these three hub genes and the lactylation level of TUBB2A in GBM tissues were significantly higher compared to those in normal tissues.ConclusionsWe propose and validate a IQR lactylation screening method that provides potential insights for GBM therapy and an effective framework for developing gene screening models applicable to other diseases and pathogenic mechanisms.…”
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Early breast cancer detection via infrared thermography using a CNN enhanced with particle swarm optimization by Riyadh M. Alzahrani, Mohamed Yacin Sikkandar, S. Sabarunisha Begum, Ahmed Farag Salem Babetat, Maryam Alhashim, Abdulrahman Alduraywish, N. B. Prakash, Eddie Y. K. Ng

“…An Enhanced Particle Swarm Optimization (EPSO) algorithm is integrated to automatically fine-tune CNN hyperparameters, thereby minimizing manual effort and enhancing computational efficiency. …”
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Golden eagle optimized CONV-LSTM and non-negativity-constrained autoencoder to support spatial and temporal features in cancer drug response prediction by Wesam Ibrahim Hajim, Suhaila Zainudin, Kauthar Mohd Daud, Khattab Alheeti

“…Advanced machine learning (ML) and deep learning (DL) methods have recently been utilized in Drug Response Prediction (DRP), and these models use the details from genomic profiles, such as extensive drug screening data and cell line data, to predict the response of drugs. …”
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Technical Code Analysis of Geomagnetic Flaw Detection of Suppression Rigging Defect Signal Based on Convolutional Neural Network by Gang Zhao, Changyu Han, Zhongxiang Yu, Zhipan Li, Guoao Yu, Hongmei Zhang, Dadong Zhao, Zhengyi Jiang

“…The single-stage object detection algorithm YOLOv5 (You Only Look Once) based on convolutional neural network model calculation is used, the scale detection layer and positioning loss function of the YOLOv5 algorithm are improved and optimized, and the improved YOLOv5 algorithm is used for experiments. …”
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An incremental data-driven approach for carbon emission prediction and optimization of heat treatment processes by Qian Yi, Xin Wu, Junkang Zhuo, Congbo Li, Chuanjiang Li, Huajun Cao

“…Using life cycle assessment (LCA) theory, carbon emission sources are accurately analyzed and quantified, and a full life cycle carbon emission model is established. The key process parameters affecting part performance and carbon emission were screened through mechanism analysis, and the incremental data were fused by the Elasticity Weight Consolidation (EWC) algorithm to establish an EWC-BPNN heat treatment carbon emission prediction model. …”
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Structural strength optimization design of ultra-high-pressure and ultra-wear-resistant pneumatic ball valve opened and closed at large explosion instantaneously using finite eleme... by Xianmei Liu, Mingcun Zhang

“…By building an ultra-high pressure burst test bench, this paper combines strain gauges and high-speed cameras to verify the accuracy of the model and corrects the simulation boundary conditions based on the Kalman filter algorithm. …”
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Maternal factors associated with early-onset neonatal sepsis among caesarean-delivered babies at Mbarara Regional Referral Hospital, Uganda: a case-control study by James M. Maisaba, Richard Migisha, Asiphas Owaraganise, Leevan Tibaijuka, David Collins Agaba, Joy Muhumuza, Joseph Ngonzi, Stella Kyoyagala, Musa Kayondo

“…We enrolled mother-baby pairs for both groups, obtaining maternal data via structured questionnaires The diagnosis of EONS was made using the WHO Young Infant Integrated Management of Childhood Illnesses algorithm. …”
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Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk by Ji-Eun Song, Ji Young Jang, Kyung Nam Kang, Ji Soo Jung, Chul Woo Kim, Ah Sol Kim

“…Breast cancer risk scores for each Breast Imaging-Reporting and Data System (BI-RADS) category in multi-microRNA analysis were analyzed to examine the correlation between breast cancer risk scores and mammography categories. We generated two models using two classification algorithms, SVM and GLM, with a combination of four miRNA biomarkers showing high performance and sensitivities of 84.5% and 82.1%, a specificity of 85%, and areas under the curve (AUCs) of 0.967 and 0.965, respectively, which showed consistent performance across all stages of breast cancer and patient ages. …”
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Nanomaterial isolated extracellular vesicles enable high precision identification of tumor biomarkers for pancreatic cancer liquid biopsy by Zachary F. Greenberg, Samantha Ali, Andrew Brock, Jinmai Jiang, Thomas D. Schmittgen, Song Han, Steven J. Hughes, Kiley S. Graim, Mei He

“…Through modelling the ATP6V0B cycling threshold, we reported 3 models with AUCs between 0.86 and 0.88, showcasing an enabling and clinically translatable liquid biopsy approach for early detection of pancreatic cancer using circulating EVs. …”
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Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis by Hang Chen, Biao Wu, Biao Wu, Kunyu Guan, Liang Chen, Kangjie Chai, Maoji Ying, Dazhi Li, Weicheng Zhao

“…Through further differential analysis and screening using machine learning algorithms, APLNR, PCDH12, PODXL, SLC40A1, TM4SF18, and TNFRSF25 were identified as key diagnostic genes for atherosclerosis. …”
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Machine learning with the body roundness index and associated indicators: a new approach to predicting metabolic syndrome by Yaxuan He, Zekai Chen, Zhaohui Tang, Yuexiang Qin, Fang Wang

“…Traditional invasive diagnostic methods are costly, inconvenient, and unsuitable for large-scale screening. Developing a non-invasive, accurate prediction model is clinically significant for early MetS detection and prevention. …”
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U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study by Yu Pan, Yan Yuan, Juan Yang, Zhu Qing Feng, Xue Yin Tang, Yi Jiang, Gui Ming Hu, Jiang Chuan Dong

“…The variables underwent screening through Least Absolute Shrinkage and Selection Operator (LASSO) regression, univariate logistic regression, and Light Gradient Boosting Machine (LightGBM), with models developed through multivariate logistic regression and the LightGBM algorithm. …”
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Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech by Julianna Olah, Win Lee Edwin Wong, Atta-ul Raheem Rana Chaudhry, Omar Mena, Sunny X. Tang

“…Linguistic and paralinguistic features were extracted and ensemble learning algorithms (e.g., XGBoost) were used to train models. …”
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Enhanced thyroid nodule detection and diagnosis: a mobile-optimized DeepLabV3+ approach for clinical deployments by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…A high IoU value in medical imaging analysis reflects the model’s ability to accurately delineate object boundaries.ConclusionDeepLabV3+ represents a significant advancement in thyroid nodule segmentation, particularly for thyroid cancer screening and diagnosis. …”
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Prevention of Cardiometabolic Syndrome in Children and Adolescents Using Machine Learning and Noninvasive Factors: The CASPIAN-V Study by Hamid Reza Marateb, Mahsa Mansourian, Amirhossein Koochekian, Mehdi Shirzadi, Shadi Zamani, Marjan Mansourian, Miquel Angel Mañanas, Roya Kelishadi

“…We applied the XGBoost algorithm to analyze key noninvasive variables, including self-rated health, sunlight exposure, screen time, consanguinity, healthy and unhealthy dietary habits, discretionary salt and sugar consumption, birthweight, and birth order, father and mother education, oral hygiene behavior, and family history of dyslipidemia, obesity, hypertension, and diabetes using five-fold cross-validation. …”
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Health-Related Quality-of-Life Utility Values in Adults With Late-Onset Pompe Disease: Analyses of EQ-5D Data From the PROPEL Clinical Trial by Alison Griffiths, Simon Shohet, Neil Johnson, Alasdair MacCulloch

“…In PROPEL, EQ-5D-5L values were assessed at screening and at weeks 12, 26, 38, and 52. EQ-5D-5L utility values were mapped to EQ-5D-3L values using the van Hout algorithm as recommended by the EuroQoL and the National Institute of Health and Care Excellence position statement at time of analysis. …”
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Retinal Microvascular Characteristics—Novel Risk Stratification in Cardiovascular Diseases by Alexandra Cristina Rusu, Klara Brînzaniuc, Grigore Tinica, Clément Germanese, Simona Irina Damian, Sofia Mihaela David, Raluca Ozana Chistol

“…This study aims to identify the retinal microvascular features associated with CHDs and evaluate their potential use in a CHD screening algorithm in conjunction with traditional risk factors. …”
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Combining first principles and machine learning for rapid assessment response of WO3 based gas sensors by Ran Zhang, Guo Chen, Shasha Gao, Lu Chen, Yongchao Cheng, Xiuquan Gu, Yue Wang

“…The collected data was subsequently utilized to develop a correlation model linking the multi-physical parameters to gas sensitive performance using intelligent algorithms. …”
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Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment by Yuriko Nakaoku, Soshiro Ogata, Kiyotaka Nemoto, Chikage Kakuta, Eri Kiyoshige, Kanako Teramoto, Kiyomasa Nakatsuka, Gantsetseg Ganbaatar, Masafumi Ihara, Kunihiro Nishimura

“…Finally, MCI identification models were developed using a penalized logistic regression model with an elastic net algorithm.ResultsAmong the 148 participants (mean age, 78.6 ± 5.2 years), 44.6% were identified as having MCI. …”
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