Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine by Yilin Meng, Lu Sui, Ligeer Che, Zihang Jin, Yutong Ma, Li Sun

“…Adaptive design and using human kidney organoid models for drug screening can determine the active ingredients efficiently. …”
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Prediction of mortality risk in patients with severe community-acquired pneumonia in the intensive care unit using machine learning by Jingjing Pan, Tao Guo, Haobo Kong, Wei Bu, Min Shao, Zhi Geng

“…Five machine learning algorithms were used to build predictive models. Models were evaluated through nested cross-validation to select the best one. …”
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Advancing clinical biochemistry: addressing gaps and driving future innovations by Haiou Cao, Enwa Felix Oghenemaro, Amaliya Latypova, Amaliya Latypova, Munthar Kadhim Abosaoda, Munthar Kadhim Abosaoda, Munthar Kadhim Abosaoda, Gaffar Sarwar Zaman, Anita Devi

“…However, concerns regarding algorithmic bias, data privacy, lack of transparency in decision-making (“black box” models), and over-reliance on automated systems pose significant challenges that must be addressed for responsible AI integration. …”
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Systematic elucidation of the effective constituents and potential mechanisms of Scrophulariae Radix against neoplasm based on LC-MS, network pharmacology, and molecular docking ap... by Shu-jie Yu, Xiao-bin Kong, Xin Jin, Meng-yi Shan, Gang Cheng, Pei-lu Wang, Wen-long Li, Pei-yuan Zhao, Yun-jie Sheng, Bing-qian He, Qi Shi, Hua-qiang Li, Qi-ming Zhao, Lu-ping Qin, Lu-ping Qin, Xiong-yu Meng, Xiong-yu Meng

“…As a result, the material–liquid ratio was significantly reduced from 100 g/mL to 32 g/mL, and the extraction efficiency was 1.332%, which was close to the predicted value of 1.346% in the response surface method, indicating that the algorithm model had a good fit. Next, a total of 738 compounds, including 161 terpenoids, 144 phenolic acids, 51 alkaloids, 24 flavonoids, 34 saccharides, 32 lignans and coumarins, 45 amino acids and derivatives, 23 organic acids, 134 lipids, 22 nucleotides and derivatives, and 59 other ingredients, were characterized from Scrophulariae Radix based on the accurate precursor and product ions, retention time, standards, fragmentation patterns, and previous publications. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…Additionally, the least absolute shrinkage and selection operator (LASSO) regression algorithm in machine learning was used to screen transcription factors such as bHLH, WRKY, and MYB that influenced the expression of TaAkPHY genes. …”
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The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity. by Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Emin Halis Akalın, Abdullah Yılmaz, Pınar Hız, Haluk Barbaros Oral

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Epidemiological and pharmacoeconomic aspects of HIV infection in military by Yu. I. Bulankov, M. A. Bulygin, A. V. Bespalov, K. V. Zhdanov, A. A. Murachev, K. S. Ivanov, Yu. I. Lyashenko

“…The research compares two competitive models: “Current Situation” - without the introduction of algorithms for early detection and treatment of HIV infection, and “Prognosis” - with the introduction of these algorithms.The following results are obtained: implementing a mandatory triennial screening for HIV-antibodies among military personnel allows to raise the detection of HIV-positive military personnel in the early stages of the disease by 55%. …”
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Мethods of Machine Learning in Ophthalmology: Review by D. D. Garri, S. V. Saakyan, I. P. Khoroshilova-Maslova, A. Yu. Tsygankov, O. I. Nikitin, G. Yu. Tarasov

“…Machine learning includes models and algorithms that mimic the architecture of biological neural networks. …”
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Shared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies by Zhang Y, Hu W, Li T, Pan Z, Sun J, He Y, Guan W, Zhang L, Lian C, Liu S, Zhang P

“…The least absolute shrinkage and selection operator (Lasso) regression algorithm of machine learning was used to screen biomarkers related to anti-MDA5+ DM.Results: Compared with HCs, 36 inflammation-related proteins were identified as DEPs. …”
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Collaborative Filtering Techniques for Predicting Web Service QoS Values in Static and Dynamic Environments: A Systematic and Thorough Analysis by Ghizlane Khababa, Sadik Bessou, Fateh Seghir, Nor Hazlyna Harun, Abdulaziz S. Almazyad, Pradeep Jangir, Ali Wagdy Mohamed

“…Key insights were gathered on algorithms, evaluation metrics, datasets, and performance outcomes, with a focus on CF methods and advancements in hybrid and context-aware models. …”
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Purine metabolism-associated key genes depict the immune landscape in gout patients by Lin-na Li, Hao Wang, Lu-shan Xiao, Wei-nan Lai

“…Using RNA-seq data of peripheral blood mononuclear cells (PBMCs) from gout patients, we screened the differentially expressed genes (DEGs) of gout patients and found that they were closely involved in purine metabolism. …”
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Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning by Shuxian Pan, Zibing Wang

“…Predictive models were constructed using three machine learning algorithms to analyze and statistically evaluate clinical characteristics, including immune cell data. …”
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Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer by Mengdi Zhu, Jinna Lin, Haohan Liu, Jingru Wang, Nianqiu Liu, Yudong Li, Hongna Lai, Qianfeng Shi

“…Using Consensus Cluster Plus and the LASSO risk model, we screened 6 acetylation-related genes (KAT2B, TAF1L, CDC37, CCDC107, C17orf106, and ASPSCR1) and constructed a 6-gene risk model of luminal breast cancer. …”
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PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients by Yufeng Wang, Huifen Dang, Gongjian Zhu, Yingxia Tian

“…LASSO Cox regression was utilized to screen genes to build a RiskScore model, and survival analysis were performed to investigate the reliability in BC prognosis. …”
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Color and Grey-Level Co-Occurrence Matrix Analysis for Predicting Sensory and Biochemical Traits in Sweet Potato and Potato by Judith Ssali Nantongo, Edwin Serunkuma, Gabriela Burgos, Mariam Nakitto, Joseph Kitalikyawe, Thiago Mendes, Fabrice Davrieux, Reuben Ssali

“…With instrumental color and texture parameters as predictors, low to moderate accuracy was detected in the machine learning models developed to predict sensory panel traits. …”
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Uncovering Hippo pathway-related biomarkers in acute myocardial infarction via scRNA-seq binding transcriptomics by Xingda Li, Xueqi He, Yu Zhang, Xinyuan Hao, Anqi Xiong, Jiayu Huang, Biying Jiang, Zaiyu Tong, Haiyan Huang, Lian Yi, Wenjia Chen

“…Three machine-learning algorithms prioritized five biomarkers (NAMPT, CXCL1, CREM, GIMAP6, and GIMAP7), validated through multi-dataset analyses and cellular expression profiling. qRT-PCR and Western blot confirmed differential expression patterns between AMI and controls across experimental models. …”
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Transcription factor networks and novel immune biomarkers reveal key prognostic and therapeutic insights in ovarian cancer by Aiqin Zhao, Sufang Zhou, Xiaoyi Yang, Haiying Lu, Dan Zou, Xuan Zhang, Li Liu

“…To analyze the percentage of invading immune cells, the algorithms CIBERSORT, ESTIMATE, and xCell were used. …”
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Transforming heart transplantation care with multi-omics insights by Zhengbang Zou, Jianing Han, Zhiyuan Zhu, Shanshan Zheng, Xinhe Xu, Sheng Liu

“…Single–cell omics technologies and machine learning algorithms further resolve cellular heterogeneity and improve predictive modeling, thereby enhancing the clinical translatability of multi-omics data. …”
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Comprehensive multi-omics and machine learning framework for glioma subtyping and precision therapeutics by Yi Ding, Zhaiyue Xu, Wenjing Hu, Peng Deng, Mian Ma, Jiandong Wu

“…The eight-gene GloMICS score outperformed 95 published prognostic models (C-index 0.74–0.66 across TCGA, CGGA and GEO). …”
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Integrative multi-omics analysis reveals the role of toll-like receptor signaling in pancreatic cancer by Jie Peng, Jiaao Sun, Youfeng Yu, Qihang Yuan, Yong Zhang

“…In the process of building prognostic models, we screened 33 core genes related to the prognosis of pancreatic cancer, and combined a series of machine learning algorithms to build the prognosis model of pancreatic cancer. …”
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