Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics by Haiting Ye, Xiang Zhang, Pengyan Li, Mei Wang, Ruolan Liu, Dingping Yang

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm, and potential associations between the hub genes and clinicopathological features were explored based on the Nephroseq database. …”
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Sleepiness, fatigue, anxiety and depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea - Overlap - Syndrome, before and after continuous positive airways... by Nicholas-Tiberio Economou, Ioannis Ilias, Lemonia Velentza, Yiannis Papachatzakis, Paul Zarogoulidis, Anastasios Kallianos, Georgia Trakada

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Identification and verification of XDH genes in ROS induced oxidative stress response of osteoarthritis based on bioinformatics analysis by Chengze Qiu, Zhiyong Zhang, Haocheng Wang, Na Liu, Ruixin Li, Zhiheng Wei, Benjie Wang, Nan Zhang

“…An artificial neural network model was constructed for the hub genes, and immune analysis was conducted using the ssGSEA algorithm. …”
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High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…Background Despite the increasing use of non-invasive respiratory support in paediatric intensive care units, there are no large randomised controlled trials comparing two commonly used non-invasive respiratory support modes, continuous positive airway pressure and high-flow nasal cannula therapy. …”
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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…This was done by enrolling patients more than 3 years after transplantation and allocating them at random to two groups. …”
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Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders by Ziqin Yang, Ziqin Yang, Nicole A. Teaney, Nicole A. Teaney, Elizabeth D. Buttermore, Elizabeth D. Buttermore, Elizabeth D. Buttermore, Mustafa Sahin, Mustafa Sahin, Mustafa Sahin, Wardiya Afshar-Saber, Wardiya Afshar-Saber

“…In this review, we compare two-dimensional and three-dimensional hiPSC formats for disease modeling, discuss the applications of functional assays, and offer insights on incorporating ML into hiPSC-based NDD research and drug screening.…”
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Identification and validation of key biomarkers associated with immune and oxidative stress for preeclampsia by WGCNA and machine learning by Tiantian Yu, Tiantian Yu, Tiantian Yu, Guiying Wang, Guiying Wang, Guiying Wang, Xia Xu, Xia Xu, Xia Xu, Jianying Yan, Jianying Yan, Jianying Yan

“…In the final step, we validated the significant hub gene using independent external datasets, the hypoxia model of the HTR-8/SVneo cell line, and human placental tissue samples.ResultsAt last, leptin (LEP) was identified as a core gene through screening and was found to be upregulated. …”
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In silico assessment of biocompatibility and toxicity: molecular docking and dynamics simulation of PMMA-based dental materials for interim prosthetic restorations by Ravinder S. Saini, Rayan Ibrahim H. Binduhayyim, Vishwanath Gurumurthy, Abdulkhaliq Ali F. Alshadidi, Shashit Shetty Bavabeedu, Rajesh Vyas, Doni Dermawan, Punnoth Poonkuzhi Naseef, Seyed Ali Mosaddad, Artak Heboyan

“…The LigandScout was utilized for pharmacophore modeling, which employs a shape-based screening approach to identify potential ligand binding sites on protein targets. …”
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Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory by Jeyanthan Charles James, Hannah Schulze, Nadine Siems, Christian Prehn, Daniel R. Quast, Nadine Trampe, Ralf Gold, Simon Faissner

“…Neurologic PCS patients had more complaints with significantly higher fatigue scores as well as higher levels of depressive and anxiety symptoms compared to Non-PCS and HC. …”
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Optimized Landing Site Selection at the Lunar South Pole: A Convolutional Neural Network Approach by Yongjiu Feng, Haoteng Li, Xiaohua Tong, Pengshuo Li, Rong Wang, Shurui Chen, Mengrong Xi, Jingbo Sun, Yuhao Wang, Huaiyu He, Chao Wang, Xiong Xu, Huan Xie, Yanmin Jin, Sicong Liu

“…The combined use of CNN and SHAP enables more effective potential site screening and a deeper understanding of the factors influencing selection. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…However, some feedback was that the intervention offered too little, too late, and that a more personalised intervention would be more helpful. …”
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Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data by Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao, Mingmang Pan

“…Furthermore, in vitro experiments successfully established a DFU oxidative stress model of fibroblasts, revealing reduced migration ability in the absence of cell death. …”
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Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study by Jingying Nong, Yu Wang, Yi Zhang

“…Epigenetic clocks, derived from sets of DNA methylation CpGs and mathematical algorithms, have demonstrated a remarkable ability to indicate biological aging and age-related health risks. …”
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Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Lea... by Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J

“…Subsequently, the hub genes were identified by Lasso and Cytoscape with three machine-learning algorithms (MCC, Degree and MCODE). In addition, hub genes were validated with ROC, single-cell sequence and IHC in hyperoxia mice. …”
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Ambulatory Oxygen for Pulmonary Fibrosis (OxyPuF): a randomised controlled trial and acceptability study by Rachel L Adams, Alisha Maher, Nicola Gale, Anjali Crawshaw, David Thickett, Alice M Turner

“…Traditional qualitative analysis and arts-based coproduction analysis approaches were used to produce a short film. An economic model was planned but could not occur due to early termination. …”
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GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis. by Guillaume Grenet, Shams Ribault, Giao Bao Nguyen, Faustine Glais, Augustin Metge, Thomas Linet, Behrouz Kassai-Koupai, Catherine Cornu, Théodora Bejan-Angoulvant, Sylvie Erpeldinger, Rémy Boussageon, Aurore Gouraud, Fabrice Bonnet, Michel Cucherat, Philippe Moulin, François Gueyffier

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Improvement of Business Analysis Method of E-Commerce System from the Perspective of Intelligent Recommendation System by Ruihua Shao

“…In recent years, with the continuous development of the country’s Internet platforms, China has gradually entered the e-commerce era of national online shopping, and more and more e-commerce platforms and stores have adopted intelligent recommendation systems to increase transaction rates. …”
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The Role of Three Plasma Proteins in the Diagnosis of Ovarian Tumors by Valeria Racheva, Adelaida Ruseva, Svetlana Mateva, Ivan Malkodanski

“…Ovarian cancer is not common, but it is still the fifth leading cause of death from malignant diseases among women worldwide. More than 200,000 women are diagnosed with ovarian cancer each year globally. …”
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Multidimensional Evaluation Framework and Classification Strategy for Low-Carbon Technologies in Office Buildings by Hongjiang Liu, Yuan Song, Yawei Du, Tao Feng, Zhihou Yang

“…The method includes four core components: (1) establishing three archetypal models—low-rise (H ≤ 24 m), mid-rise (24 m < H ≤ 50 m), and high-rise (50 m < H ≤ 100 m) office buildings—based on 99 office buildings in Beijing; (2) classifying 19 key technologies into three clusters—Envelope Structure Optimization, Equipment Efficiency Enhancement, and Renewable Energy Utilization—using bibliometric analysis and policy norm screening; (3) developing a four-dimensional evaluation framework encompassing Carbon Reduction Degree (CRD), Economic Viability Degree (EVD), Technical Applicability Degree (TAD), and Carbon Intensity Degree (CID); and (4) conducting a comprehensive quantitative evaluation using the AHP-entropy-TOPSIS algorithm. …”
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Community-based COVID-19 active case finding and rapid response in the Democratic Republic of the Congo: Improving case detection and response. by John Otokoye Otshudiema, Gervais Léon Tengomo Folefack, Justus M Nsio, Cathy H Kakema, Luigino Minikulu, Aimé Bafuana, Joel B Kosianza, Antoine K Mfumu, Edith Nkwembe, Yannick Munyeku-Bazitama, Sheila Makiala-Mandanda, Noé Guinko, Gisèle Mbuyi, Jean-Marie K Tshilumbu, Guy N Saidi, Moreau-Serge Umba-di-Masiala, Amos K Ebondo, Jean-Jacques Mutonj, Serge Kalombo, Jad Kabeya, Taty K Mawanda, Faustin N Bile, Gaby K Kasereka, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Humphrey Cyprian Karamagi, Karl Njuwa Fai, Amédée Prosper Djiguimde

“…This pilot study was modeled on the DRC's National COVID-19 Response Plan and the COVID-19 Ag-RDT screening algorithm defined by the World Health Organization (WHO), with case findings implemented in 259 health areas, 39 health zones, and 9 provinces. …”
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