Identification of novel cyclin-dependent kinase 4/6 inhibitors from marine natural products. by Abhijit Debnath, Rupa Mazumder, Anil Kumar Singh, Rajesh Kumar Singh

“…These 25 candidates underwent consensus molecular docking using seven distinct algorithms: AutoDockTools 4.2, idock, LeDock, Qvina 2, Smina, AutoDock Vina 1.2.0, PLANTS, and rDock. …”
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The Clinical Significance of the Dense Fine Speckled Immunofluorescence Pattern on HEp-2 Cells for the Diagnosis of Systemic Autoimmune Diseases by Michael Mahler, Marvin J. Fritzler

“…The indirect immunofluorescence (IIF) assay on HEp-2 cells is a commonly used test for the detection of ANA and has been recently recommended as the screening test of choice by a task force of the American College of Rheumatology. …”
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Design, Fabrication, and Application of Large-Area Flexible Pressure and Strain Sensor Arrays: A Review by Xikuan Zhang, Jin Chai, Yongfu Zhan, Danfeng Cui, Xin Wang, Libo Gao

“…The rapid development of flexible sensor technology has made flexible sensor arrays a key research area in various applications due to their exceptional flexibility, wearability, and large-area-sensing capabilities. …”
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Integrated single-cell and transcriptome sequencing data reveal the value of IL1RAP in gastric cancer microenvironment and prognosis by Weifeng Yang, Xiaohua Wu, Jian Wang, Wenquan Ou, Xing Huang

“…Three machine learning algorithms identified distinct sets of prognostic genes in gastric cancer patients. …”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2008 Update – Highlights for Primary Care by Denis E O’Donnell, Paul Hernandez, Alan Kaplan, Shawn Aaron, Jean Bourbeau, Darcy Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Yves Lacasse, Francois Maltais, Jeremy Road, Graeme Rocker, Don Sin, Tasmin Sinuff, Nha Voduc

“…Three key messages contained in the update are: use targeted screening spirometry to establish a diagnosis and initiate prompt management (including smoking cessation) of mild COPD; improve dyspnea and activity limitation in stable COPD using new evidence-based treatment algorithms; and understand the importance of preventing and managing acute exacerbations, particularly in moderate to severe disease.…”
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High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…Background Despite the increasing use of non-invasive respiratory support in paediatric intensive care units, there are no large randomised controlled trials comparing two commonly used non-invasive respiratory support modes, continuous positive airway pressure and high-flow nasal cannula therapy. …”
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Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: implications for tuberculosis control in the era of HIV. by Helen Ayles, Albertus Schaap, Amos Nota, Charalambos Sismanidis, Ruth Tembwe, Petra De Haas, Monde Muyoyeta, Nulda Beyers, Peter Godfrey-Faussett for the ZAMSTAR Study Team

“…Epidemiological studies can inform screening algorithms for both detection and prevention of active tuberculosis.…”
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Rapid Lactic Acid Content Detection in Secondary Fermentation of Maize Silage Using Colorimetric Sensor Array Combined with Hyperspectral Imaging by Xiaoyu Xue, Haiqing Tian, Kai Zhao, Yang Yu, Ziqing Xiao, Chunxiang Zhuo, Jianying Sun

“…The coronavirus herd immunity optimizer (CHIO) algorithm was introduced to screen three color-sensitive dyes that are more sensitive to changes in lactic acid content of maize silage. …”
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How math shapes the world of life science animation by Rafael Oliveira, Evellyn Araujo Dias, Evellyn Araujo Dias, Ricardo Santos, Ricardo Santos, Vinicius Cotta-De-Almeida, José Aguiar Coelho Nt, José Aguiar Coelho Nt, José Aguiar Coelho Nt, Luiz Anastácio Alves

“…This paper elucidates the role of matrix manipulation in animating figures on screens, elucidates the distinctions between Scalable Vector Graphics (SVG), bitmap and raster images, and unveils the inner workings of the Bresenham algorithm in the context of rendering lines on screens. …”
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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. by Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall

“…Analysis of the IBD regions also allows us to calculate the ENU mutation rate (1.54 mutations per Mb) and to model future strategies for genetic screens in mice. The introduction of this approach will accelerate the discovery of causal variants, permit broader and more informative lethal screens to be used, reduce animal costs, and herald a new era for ENU mutagenesis.…”
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Design and predict the potential of imidazole-based organic dyes in dye-sensitized solar cells using fingerprint machine learning and supported by a web application by Mohamed M. Elsenety

“…Based on the RDKit library, several fingerprints such as Molecular ACCess System, Avalon, Daylight, Pharmacophore and Morgan with different radius (r2, r3, r4), were studied. In addition, more than 20 ML algorithms using different cross validation (3, 5, 7, 10) were also evaluated. …”
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Robustness evaluation of commercial liveness detection platform by Pengcheng WANG, Haibin ZHENG, Jianfei ZOU, Ling PANG, Hu LI, Jinyin CHEN

“…Liveness detection technology has become an important application in daily life, and it is used in scenarios including mobile phone face unlock, face payment, and remote authentication.However, if attackers use fake video generation technology to generate realistic face-swapping videos to attack the living body detection system in the above scenarios, it will pose a huge threat to the security of these scenarios.Aiming at this problem, four state-of-the-art Deepfake technologies were used to generate a large number of face-changing pictures and videos as test samples, and use these samples to test the online API interfaces of commercial live detection platforms such as Baidu and Tencent.The test results show that the detection success rate of Deepfake images is generally very low by the major commercial live detection platforms currently used, and they are more sensitive to the quality of images, and the false detection rate of real images is also high.The main reason for the analysis may be that these platforms were mainly designed for traditional living detection attack methods such as printing photo attacks, screen remake attacks, and silicone mask attacks, and did not integrate advanced face-changing detection technology into their liveness detection.In the algorithm, these platforms cannot effectively deal with Deepfake attacks.Therefore, an integrated live detection method Integranet was proposed, which was obtained by integrating four detection algorithms for different image features.It could effectively detect traditional attack methods such as printed photos and screen remakes.It could also effectively detect against advanced Deepfake attacks.The detection effect of Integranet was verified on the test data set.The results show that the detection success rate of Deepfake images by proposed Integranet detection method is at least 35% higher than that of major commercial live detection platforms.…”
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Predicting the generalization of computer aided detection (CADe) models for colonoscopy by Joel Shor, Carson McNeil, Yotam Intrator, Joseph R. Ledsam, Hiro-o Yamano, Daisuke Tsurumaru, Hiroki Kayama, Atsushi Hamabe, Koji Ando, Mitsuhiko Ota, Haruei Ogino, Hiroshi Nakase, Kaho Kobayashi, Masaaki Miyo, Eiji Oki, Ichiro Takemasa, Ehud Rivlin, Roman Goldenberg

“…Abstract Generalizability of AI colonoscopy algorithms is important for wider adoption in clinical practice. …”
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Artificial intelligence-based automated breast ultrasound radiomics for breast tumor diagnosis and treatment: a narrative review by Yinglin Guo, Ning Li, Chonghui Song, Juan Yang, Yinglan Quan, Hongjiang Zhang

“…Consequently, for early-stage BC, timely screening, accurate diagnosis, and the development of personalized treatment strategies are crucial for enhancing patient survival rates. …”
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Artificial intelligence in molecular and genomic prostate cancer diagnostics by A. O. Morozov, A. K. Bazarkin, S. V. Vovdenko, M. S. Taratkin, M. S. Balashova, D. V. Enikeev

“…They have the potential to develop artificial intelligence (AI) algorithms by processing large amounts of data and define connections between them.Objective. …”
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Breast lesion classification via colorized mammograms and transfer learning in a novel CAD framework by Abbas Ali Hussein, Morteza Valizadeh, Mehdi Chehel Amirani, Sedighe Mirbolouk

“…As a consequence of this conversion, breast tumors with anomalies become more visible, which allows us to extract more accurate features about them. …”
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Predicting cardiotoxicity in drug development: A deep learning approach by Kaifeng Liu, Huizi Cui, Xiangyu Yu, Wannan Li, Weiwei Han

“…This study not only improved the predictive accuracy of cardiotoxicity models but also promoted a more reliable and scientifically interpretable method for drug safety assessment. …”
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Enhancing Stroke Prediction with Logistic Regression and Support Vector Machine Using Oversampling Techniques by Syamsul Risal, Fajar Apriyadi, A. Sumardin, Andini Dani Achmad, Annisa Nurul Puteri

“…Simultaneously, SVM with Borderline-SMOTE may be more appropriate for resource-constrained environments.…”
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Design and validation of a novel multiple sites signal acquisition and analysis system based on pressure stimulation for human cardiovascular information by Gaiqin Liu, Yuan Li, Longcong Chen, Juan Jiang, Jie Tian, Panpan Feng

“…Therefore, it is crucial to maximize the acquisition of cardiovascular information (CVI) through non-invasive methods to enhance early screening, diagnosis, and evaluation of CVDs. Numerous studies have demonstrated that obtaining more CVI by simultaneously acquiring multi-site signals and applying pressure stimulation at specific sites, such as blood pressure measurement, is an effective approach. …”
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Cysticercosis in Madagascar by Jean-François Carod, Pierre Dorny

“…Neurocysticercosis (NCC) is the most common pattern of cysticercosis in Madagascar and it is reponsible for pediatric morbidity causing more than 50% of epilepsy cases. Though CT-Scan is now available and tends to be considered the gold standard for NCC diagnosis, it remains unaffordable for most Malagasy patients and implies the proposal of a diagnostic algorithm for physicians. …”
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