Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease by Jing Xu, Hangyu Chen, Jingang Yang, Yanmin Yang, Yuan Wu, Jun Zhang, Jiansong Yuan, Tianjie Wang, Tao Tian, Jia Li, Xueyan Zhao, Xiaojin Gao, Jie Lu, Lin Li, Lei Zhang, Xuehui Li, Long Chen, Chuan He, Chaoran Dong, Jian Lin, Weixian Yang, Yuejin Yang

“…Using machine learning algorithms, we identified inflammation-related 5hmC modifications associated with disease severity and constructed a classification model based on key hydroxymethylated markers. …”
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ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target by Lei Tang, Xiyue Wang, Zhengzheng Xia, Jiayu Yan, Shanshan Lin

“…Results Through a rigorous multi-algorithm screening process, ATP6AP1 was found to be a highly reliable biomarker with an area under the curve (AUC) of 0.979. …”
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Digital mapping of peat thickness and extent in Finland using remote sensing and machine learning by Jonne Pohjankukka, Timo A. Räsänen, Timo P. Pitkänen, Arttu Kivimäki, Ville Mäkinen, Tapio Väänänen, Jouni Lerssi, Aura Salmivaara, Maarit Middleton

“…We carefully split the reference data into training and test sets, allowing for independent and robust model validation. Feature selection included an initial screening for multicollinearity using correlation-based feature pruning, followed by final selection using a genetic algorithm. …”
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Postpartum depression in Northeastern China: a cross-sectional study 6 weeks after giving birth by XuDong Huang, LiFeng Zhang, ChenYang Zhang, Jing Li, ChenYang Li

“…Feature importance was ranked via a random forest model based on the change in ROC-AUC after predictor removal. …”
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Drug–target interaction prediction by integrating heterogeneous information with mutual attention network by Yuanyuan Zhang, Yingdong Wang, Chaoyong Wu, Lingmin Zhan, Aoyi Wang, Caiping Cheng, Jinzhong Zhao, Wuxia Zhang, Jianxin Chen, Peng Li

“…DrugMAN uses a graph attention network-based integration algorithm to learn network-specific low-dimensional features for drugs and target proteins by integrating four drug networks and seven gene/protein networks collected by a certain screening conditions, respectively. …”
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Machine Learning for Predicting Zearalenone Contamination Levels in Pet Food by Zhenlong Wang, Wei An, Jiaxue Wang, Hui Tao, Xiumin Wang, Bing Han, Jinquan Wang

“…Other algorithms showed moderate accuracy, ranging from 77.1% to 84.8%. …”
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Interpretable machine learning for depression recognition with spatiotemporal gait features among older adults: a cross-sectional study in Xiamen, China by Shaowu Lin, Sicheng Li, Ya Fang

“…The developed machine learning models with high predictive accuracy, suggest the potential of Kinect-based gait assessment as a real-time and cost-effective screening tool for older adults with depressive symptoms.…”
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Detection of Undiagnosed Liver Cirrhosis via Artificial Intelligence-Enabled Electrocardiogram (DULCE): Rationale and design of a pragmatic cluster randomized clinical trial by Amy Olofson, Ryan Lennon, Blake Kassmeyer, Kan Liu, Zacchi I. Attia, David Rushlow, Puru Rattan, Joseph C. Ahn, Paul A. Friedman, Alina Allen, Patrick S. Kamath, Vijay H. Shah, Peter A. Noseworthy, Douglas A. Simonetto

“…A novel electrocardiogram (ECG)-enabled deep learning model trained for detection of advanced chronic liver disease (CLD) has demonstrated promising results and it may be used for screening of advanced CLD in primary care. …”
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Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation by Yoonsung Kwon, Asta Blazyte, Yeonsu Jeon, Yeo Jin Kim, Kyungwhan An, Sungwon Jeon, Hyojung Ryu, Dong-Hyun Shin, Jihye Ahn, Hyojin Um, Younghui Kang, Hyebin Bak, Byoung-Chul Kim, Semin Lee, Hyung-Tae Jung, Eun-Seok Shin, Jong Bhak

“…Subsequent validation of identified biomarkers employed an artificial intelligence-based risk prediction models: a linear calculation-based methylation risk score model and two tree-based machine learning models: Random Forest and XGBoost. …”
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Ekyeyo Mobile Application by Nkuba, Blair, Kansiime, Daniel

“…The app incorporates advanced search algorithms, tailored job recommendations, and streamlined candidate screening to improve job-matching accuracy. …”
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Opportunities and Challenges of Cardiovascular Disease Risk Prediction for Primary Prevention Using Machine Learning and Electronic Health Records: A Systematic Review by Tianyi Liu, Andrew J. Krentz, Zhiqiang Huo, Vasa Ćurčin

“…The synthesis underscores the superiority of ML in modeling intricate EHR-derived risk factors, facilitating precision-driven cardiovascular risk assessment. …”
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Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer by Mengdi Zhu, Jinna Lin, Haohan Liu, Jingru Wang, Nianqiu Liu, Yudong Li, Hongna Lai, Qianfeng Shi

“…Using Consensus Cluster Plus and the LASSO risk model, we screened 6 acetylation-related genes (KAT2B, TAF1L, CDC37, CCDC107, C17orf106, and ASPSCR1) and constructed a 6-gene risk model of luminal breast cancer. …”
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TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by Linlin Tang, Yangli Jin, Jinxu Wang, Xiuyan Lu, Mengque Xu, Mingwei Xiang

“…Results 157 genes related to inflammation and ferroptosis in HCC were obtained by WGCNA. rLasso algorithm, with the highest C-index, screened out 29 hub genes, and this model showed good efficacy to predict the prognosis of HCC patients. …”
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Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers by Cunen Wu, Cunen Wu, Cunen Wu, Cunen Wu, Weiwei Xue, Yuwen Zhuang, Dayue Darrel Duan, Dayue Darrel Duan, Zhou Zhou, Zhou Zhou, Xiaoxiao Wang, Zhenfeng Wu, Jin-yong Zhou, Xiangkun Huan, Ruiping Wang, Haibo Cheng, Haibo Cheng

“…A pan-cancer predictive model for ICI prognosis based on ANSDR.Sig was constructed, with the random forest algorithm yielding the most robust performance. …”
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Novel insights of disulfidptosis-mediated immune microenvironment regulation in atherosclerosis based on bioinformatics analyses by Huanyi Zhao, Zheng Jin, Junlong Li, Junfeng Fang, Wei Wu, J. F. Fang

“…In addition, we established a foam cell model in vitro and an AS mouse model in vivo to verify the expressions of hub genes. …”
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Cadmium Exposure Disrupts Uterine Energy Metabolism and Coagulation Homeostasis During Labor in Institute of Cancer Research Mice: Insights from Transcriptomic Analysis by Yueyang Wang, Yichen Bai, Yi Wang, Yan Cai

“…This study is the first to establish a model of Cd exposure in the uterus of laboring mice and investigate the underlying metabolic mechanisms through transcriptomic analysis. …”
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Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning by Shuxian Pan, Zibing Wang

“…Predictive models were constructed using three machine learning algorithms to analyze and statistically evaluate clinical characteristics, including immune cell data. …”
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Plasma metabolite biomarker identification study for the early detection of gastric cancer by Juan Zhu, Yida Huang, Bin Liu, Xue Li, Li Yuan, Le Wang, Kun Qian, Yingying Mao, Lingbin Du, Xiangdong Cheng

“…Ultra-performance liquid chromatography–mass spectrometry–based metabolomics methods were used to characterize the subjects’ plasma metabolic profiles and to screen and validate the GC biomarkers. Five machine learning algorithms (neural network, support vector machine, ridge regression, lasso regression and Naïve Bayes) were used to build a diagnostic model. …”
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Multi-Dimensional Lithology Identification Method Based on Microresistivity Image Logging by LIU Juan, MIN Xuanlin, QI Zhongli, YI Jun, LAI Fuqiang, ZHOU Wei

“…For the electrical imaging color features of different resistivity responses (mudstone, calcareous mudstone and sandy mudstone), K-means++ algorithm is used to screen out the clustering centers of the overall distribution of the data set to achieve fast classification of the electro-imaging colors. …”
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The use of heart rate variability, oxygen saturation, and anthropometric data with machine learning to predict the presence and severity of obstructive sleep apnea by Rafael Rodrigues dos Santos, Matheo Bellini Marumo, Alan Luiz Eckeli, Helio Cesar Salgado, Luiz Eduardo Virgílio Silva, Renato Tinós, Rubens Fazan

“…IntroductionObstructive sleep apnea (OSA) is a prevalent sleep disorder with a high rate of undiagnosed patients, primarily due to the complexity of its diagnosis made by polysomnography (PSG). Considering the severe comorbidities associated with OSA, especially in the cardiovascular system, the development of early screening tools for this disease is imperative. …”
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