Case-control study combined with machine learning techniques to identify key genetic variations in GSK3B that affect susceptibility to diabetic kidney diseases by Jinfang Song, Yi Xu, Liu Xu, Tingting Yang, Ya Chen, Changjiang Ying, Qian Lu, Tao Wang, Xiaoxing Yin

“…On the other hand, the expression levels and kinase activity of GSK3β in exosomes differed significantly between patients with different genotypes of the GSK3B, suggesting that the effect of GSK3B gene polymorphisms on GSK3β expression and activity may be an important mechanism leading to individual differences in susceptibility to DKD. XG Boost algorithm model identified rs60393216 and rs1488766 as important biomarkers for clinical early warning of DKD.…”
Get full text

Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning by Qiao Tang, Yanwei Ji, Zhongyuan Xia, Yuxi Zhang, Chong Dong, Chong Dong, Qian Sun, Shaoqing Lei

“…The ERDEGs diagnostic model was developed based on a combination of LASSO and Random Forest approaches, and the diagnostic performance was evaluated by the area under the receiver operating characteristic curve (ROC-AUC) and validated against external datasets. …”
Get full text

The Future of Minimally Invasive GI and Capsule Diagnostics (REFLECT), October 2024 by Lea Østergaard Hansen, Alexandra Agache, Anastasios Koulaouzidis

“…The symposium also highlighted the significance of predictive models for patient selection and developments in panenteric CE. …”
Get full text

Effect of miR-200c on inducing autophagy and apoptosis of HT22 cells from mouse hippocampal neurons via regulating PRDM1 protein: a bioinformatics analysis by W. Wu, J. Fu, Q. Liu, Q. Wang, S. Gao, X. Deng, C. Shen

“…The Support Vector Machine (SVM) algorithm in the Weka software was used to process, model, and screen the available miRNA data. …”
Get full text

A low-cost platform for automated cervical cytology: addressing health and socioeconomic challenges in low-resource settings by José Ocampo-López-Escalera, Héctor Ochoa-Díaz-López, Xariss M. Sánchez-Chino, César A. Irecta-Nájera, Saúl D. Tobar-Alas, Martha Rosete-Aguilar

“…This disease is preventable and curable if detected in early stages, making regular screening critically important. Cervical cytology, the most widely used screening method, has proven highly effective in reducing cervical cancer incidence and mortality in high income countries. …”
Get full text

Recent Trends and Advances in Utilizing Digital Image Processing for Crop Nitrogen Management by Bhashitha Konara, Manokararajah Krishnapillai, Lakshman Galagedara

“…A total of 95 articles remained after the screening and selection process. Interest in integrating machine learning and deep learning algorithms with DIP has increased, with the frequently used algorithms—Random Forest, Support Vector Machine, Extreme Gradient Boost, and Convolutional Neural Networks—achieving higher prediction accuracy levels. …”
Get full text

Distinguish the Value of the Benign Nevus and Melanomas Using Machine Learning: A Meta-Analysis and Systematic Review by Suli Li, Yihang Chu, Ying Wang, Yantong Wang, Shipeng Hu, Xiangye Wu, Xinwei Qi

“…This suggests that state-of-the-art ML-based algorithms for distinguishing melanoma from benign nevi may be ready for clinical use. …”
Get full text

Keypoint Detection Based on Curvature Grouping and Adaptive Sampling by Bifu Li, Yu Cheng, Weitong Li

“…In the keypoint detection algorithm, the farthest point sampling methods and random sampling methods are usually used to select candidate points, then keypoints are screened out from the neighborhood of the candidate points. …”
Get full text

Prediction of additional hospital days in patients undergoing cervical spine surgery with machine learning methods by Bin Zhang, Shengsheng Huang, Chenxing Zhou, Jichong Zhu, Tianyou Chen, Sitan Feng, Chengqian Huang, Zequn Wang, Shaofeng Wu, Chong Liu, Xinli Zhan

“…The intersections of the variables screened by the aforementioned algorithms were utilized to construct a nomogram model for predicting AHD in patients. …”
Get full text

Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment by Chuanyu Ma, Chuanyu Ma, Guandu Li, Xiaohan Song, Xiaochen Qi, Tao Jiang

“…GO and KEGG pathway enrichment analyses were performed on these 103 positively correlated differentially expressed genes, and the proportion and type of tumour-infiltrating immune cells were assessed by TIMER, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, MCPCOUNTER, XCELL and EPIC algorithms in patients. In addition, we calculated the relevance of immunotherapy and predicted various drugs that might be used for treatment and evaluated the predictive power of survival models under multiple machine learning algorithms through the training set TCGA-PRAD versus the validation set PRAD-FR cohort. …”
Get full text

Focusing on scRNA-seq-Derived T Cell-Associated Genes to Identify Prognostic Signature and Immune Microenvironment Status in Low-Grade Glioma by Jiayu Wen, Qiaoyi Huang, Jiuxiu Yao, Wei Wei, Zehui Li, Huiqin Zhang, Surui Chang, Hui Pei, Yu Cao, Hao Li

“…In addition, bulk RNA data of 975 LGG samples were collected for model construction. Algorithms such as TIMER, CIBERSORT, QUANTISEQ, MCPCOUTER, XCELL, and EPIC were used to depict the tumor microenvironment landscape. …”
Get full text

CNN-Based Medical Ultrasound Image Quality Assessment by Siyuan Zhang, Yifan Wang, Jiayao Jiang, Jingxian Dong, Weiwei Yi, Wenguang Hou

“…At last, some tests are taken to evaluate the IQA models. They show that the CNN-based IQA is feasible and effective.…”
Get full text

Advances in the application of machine learning technology in the field of environmental health by ZHENG Yu, LI Cheng, HU Guiping, JIA Guang

“…However, the application of ML technology in the field of environmental health still faces challenges such as data quality, model interpretability, and interdisciplinary cooperation. …”
Get full text

Serum Lipid Biomarkers for the Diagnosis and Monitoring of Neuromyelitis Optica Spectrum Disorder: Towards Improved Clinical Management by Li R, Wang J, Wang J, Xie W, Song P, Zhang J, Xu Y, Tian D, Wu L, Wang C

“…Subsequently, we validated the candidate biomarkers in the retrospective cohort and developed diagnostic models using a random forest algorithm. The association between these lipid biomarkers and disease activity was further evaluated in longitudinal analysis.Results: Our analysis identified a panel of serum lipid-related biomarkers that demonstrated significant differences between NMOSD patients and controls. …”
Get full text

Study on classification of aluminum plastic packaging tablets for drugs based on SOM-FDA using XRF spectroscopy(基于SOM-FDA利用XRF对药品铝塑包装片的分类) by 姜红(JIANG Hong), 康瑞雪(KANG Ruixue), 郝小辉(HAO Xiaohui)

“…The established classification model is scientifically accurate and can provide assistance for public security organs in large-scale screening, determining investigation directions, and shortening investigation time.…”
Get full text

Immunotyping of thyroid cancer for clinical outcomes and implications by Jin Xu, Zhen Luo, Dayong Xu, Mujing Ke, Cheng Tan

“…Furthermore, the prognostic model’s utility in predicting immunotherapy response was analyzed. …”
Get full text

Systemic immune-inflammatory biomarkers combined with the CRP-albumin-lymphocyte index predict surgical site infection following posterior lumbar spinal fusion: a retrospective stu... by Zixiang Pang, Jiawei Liang, Jiayi Chen, Yangqin Ou, Qinmian Wu, Shengsheng Huang, Shengbin Huang, Yuanming Chen

“…Internal validation employed ROC analysis and calibration curves, while Shapley Additive Explanations (SHAP) values interpreted feature importance in the optimal model.ResultsAmong 2,921 screened patients, 1,272 met inclusion criteria. …”
Get full text

A reproducible approach for the use of aptamer libraries for the identification of Aptamarkers for brain amyloid deposition based on plasma analysis. by Cathal Meehan, Soizic Lecocq, Gregory Penner

“…Eight aptamers were identified as a result of the selection process and screened across 390 plasma samples by qPCR assay. Results were analysed using multiple machine learning algorithms from the Scikit-learn package along with clinical variables including cognitive status, age and sex to create predictive models. …”
Get full text

Utilising AI technique to identify depression risk among doctoral students by Changhong Teng, Chunmei Yang, Qiushi Liu

“…Based on the data from the 2019 Nature Global Doctoral Student Survey, we first screened 13 highly relevant features from a total of 37 features potentially related to the risk of depression among doctoral students by Random Forest algorithm. …”
Get full text

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. by Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall

“…Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. …”
Get full text