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1021
Exploring pesticide risk in autism via integrative machine learning and network toxicology
Published 2025-06-01“…Each combination of 1–23 targets was used to construct predictive models using eight different machine learning algorithms. …”
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1022
Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target
Published 2025-02-01“…Finally, a novel RCC prognostic marker PIF1 was identified in model genes. The knockdown of PIF1 in vitro inhibited the progression of renal carcinoma cells. …”
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1023
Identification and validation of the diagnostic biomarker MFAP5 for CAVD with type 2 diabetes by bioinformatics analysis
Published 2024-12-01“…Machine learning (ML) algorithms were employed to screen potential biomarkers. …”
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1024
Signatures of Six Autophagy‐Related Genes as Diagnostic Markers of Thyroid‐Associated Ophthalmopathy and Their Correlation With Immune Infiltration
Published 2024-12-01“…The combined six‐gene model also showed good diagnostic efficacy (AUC = 0.948). …”
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1025
Identifying and Validating an Acidosis-Related Signature Associated with Prognosis and Tumor Immune Infiltration Characteristics in Pancreatic Carcinoma
Published 2021-01-01“…Univariate Cox regression and the Kaplan–Meier method were applied to screen for prognostic genes. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to establish the optimal model. …”
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1026
Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics
Published 2025-03-01“…Immune cell infiltration was analyzed using the CIBERSORT algorithm, and potential associations between the hub genes and clinicopathological features were explored based on the Nephroseq database. …”
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1027
Cell death-related signature genes: risk-predictive biomarkers and potential therapeutic targets in severe sepsis
Published 2025-05-01“…Further combining cell death-related gene screening and four machine learning algorithms (including LASSO-logistic, Gradient Boosting Machine, Random Forest and xGBoost), nine SeALAR-characterized cell death genes (SeDGs) were screened and a risk prediction model based on SeDGs was constructed that demonstrated good prediction performance. …”
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1028
Opening closed doors: using machine learning to explore factors associated with marital sexual violence in a cross-sectional study from India
Published 2021-12-01“…Analyses included iterative thematic analysis (L-1 regularised regression followed by iterative qualitative thematic coding of L-2 regularised regression results) and neural network modelling.Outcome measure Participants reported their experiences of sexual violence perpetrated by their current (or most recent) husband in the previous 12 months. …”
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1029
Improving the accuracy of remotely sensed TSS and turbidity using quality enhanced water reflectance by a statistical resampling technique
Published 2025-08-01“…The statistical resampling approach based on GMM was applied to Sentinel-2 (S2) imagery to produce input to Machine Learning (ML) algorithms to retrieve the TSS and turbidity for target river sections. …”
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1030
Characterization and stratification of risk factors of stroke in people living with HIV: A theory-informed systematic review
Published 2025-05-01“…Predictive and preventative models should target factors with a high causality index and low investigative costs. …”
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1031
Characterization of the salivary microbiome in healthy individuals under fatigue status
Published 2025-05-01“…Bioinformatics analyses encompassed assessment of alpha and beta diversity, identification of differential taxa using Linear discriminant analysis Effect Size (LEfSe) with multi-method cross-validation, construction of microbial co-occurrence networks, and screening of fatigue-associated biomarker genera via the Boruta-SHAP algorithm. …”
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1032
Identification and verification of XDH genes in ROS induced oxidative stress response of osteoarthritis based on bioinformatics analysis
Published 2025-08-01“…An artificial neural network model was constructed for the hub genes, and immune analysis was conducted using the ssGSEA algorithm. …”
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1033
Automated interpretation of influenza hemagglutination inhibition (HAI) assays: Is plate tilting necessary?
Published 2017-01-01“…In a side-by-side comparison study performed during FDA's biannual serological screening process for influenza viruses, titer calls for more than 2200 serum samples were made by the Cypher One automated hemagglutination analyzer without tilting and by an expert human with tilting. …”
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1034
Neutrophil extracellular traps-related genes contribute to sepsis-associated acute kidney injury
Published 2025-05-01“…Differentially expressed genes were screened by “limma” package in R. Least absolute shrinkage and selection operator algorithm was applied to identify the hub genes. …”
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1035
Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders
Published 2025-01-01“…In this review, we compare two-dimensional and three-dimensional hiPSC formats for disease modeling, discuss the applications of functional assays, and offer insights on incorporating ML into hiPSC-based NDD research and drug screening.…”
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1036
Real-World Parkinson’s Hand Tremor Detection Using Ensemble Learning Techniques
Published 2025-01-01“…Our method first applies a dynamic scanning mechanism to screen out valid walking fragments from whole walking sequence. …”
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1037
Identification and verification of biomarkers associated with neutrophils in acute myocardial infarction: integrated analysis of bulk RNA-seq, expression quantitative trait loci, a...
Published 2025-08-01“…Hub genes were screened using the least absolute shrinkage and selection operator (LASSO) and random forest (RF) algorithms. …”
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Article -
1038
Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data
Published 2025-07-01“…Furthermore, in vitro experiments successfully established a DFU oxidative stress model of fibroblasts, revealing reduced migration ability in the absence of cell death. …”
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1039
Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study
Published 2025-06-01“…Epigenetic clocks, derived from sets of DNA methylation CpGs and mathematical algorithms, have demonstrated a remarkable ability to indicate biological aging and age-related health risks. …”
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1040
Breast lesion classification via colorized mammograms and transfer learning in a novel CAD framework
Published 2025-07-01“…In a subsequent step, Machine Learning (ML) algorithms are employed to classify these tumors as malign or benign cases. …”
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Article