Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers by Cunen Wu, Cunen Wu, Cunen Wu, Cunen Wu, Weiwei Xue, Yuwen Zhuang, Dayue Darrel Duan, Dayue Darrel Duan, Zhou Zhou, Zhou Zhou, Xiaoxiao Wang, Zhenfeng Wu, Jin-yong Zhou, Xiangkun Huan, Ruiping Wang, Haibo Cheng, Haibo Cheng

“…A pan-cancer predictive model for ICI prognosis based on ANSDR.Sig was constructed, with the random forest algorithm yielding the most robust performance. …”
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Progress and challenges of artificial intelligence in lung cancer clinical translation by Erjia Zhu, Amgad Muneer, Jianjun Zhang, Yang Xia, Xiaomeng Li, Caicun Zhou, John V. Heymach, Jia Wu, Xiuning Le

“…Abstract Artificial intelligence (AI) algorithms, such as convolutional neural networks and transformers, have significantly impacted cancer care. …”
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Systemic immune-inflammatory biomarkers combined with the CRP-albumin-lymphocyte index predict surgical site infection following posterior lumbar spinal fusion: a retrospective stu... by Zixiang Pang, Jiawei Liang, Jiayi Chen, Yangqin Ou, Qinmian Wu, Shengsheng Huang, Shengbin Huang, Yuanming Chen

“…Internal validation employed ROC analysis and calibration curves, while Shapley Additive Explanations (SHAP) values interpreted feature importance in the optimal model.ResultsAmong 2,921 screened patients, 1,272 met inclusion criteria. …”
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Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis by Bernard Friedenson

“…EBV-transformed human mammary cells accelerate breast cancer when transplanted into immunosuppressed mice, but the virus can disappear as malignant cells reproduce. If this model applies to human breast cancers, then they should have genome damage characteristic of EBV infection. …”
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Dielectric tensor prediction for inorganic materials using latent information from preferred potential by Zetian Mao, WenWen Li, Jethro Tan

“…We develop an equivariant readout decoder to predict total, electronic, and ionic dielectric tensors while preserving O(3) equivariance, and benchmark its performance against state-of-the-art algorithms. Virtual screening of thermodynamically stable materials from Materials Project for two discovery tasks, high-dielectric and highly anisotropic materials, identifies promising candidates including Cs2Ti(WO4)3 (band gap E g = 2.93eV, dielectric constant ε = 180.90) and CsZrCuSe3 (anisotropic ratio α r = 121.89). …”
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Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…Ninety‐eight machine learning algorithm combinations were screened to identify the optimal predictive model. …”
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Case-control study combined with machine learning techniques to identify key genetic variations in GSK3B that affect susceptibility to diabetic kidney diseases by Jinfang Song, Yi Xu, Liu Xu, Tingting Yang, Ya Chen, Changjiang Ying, Qian Lu, Tao Wang, Xiaoxing Yin

“…On the other hand, the expression levels and kinase activity of GSK3β in exosomes differed significantly between patients with different genotypes of the GSK3B, suggesting that the effect of GSK3B gene polymorphisms on GSK3β expression and activity may be an important mechanism leading to individual differences in susceptibility to DKD. XG Boost algorithm model identified rs60393216 and rs1488766 as important biomarkers for clinical early warning of DKD.…”
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Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning by Qiao Tang, Yanwei Ji, Zhongyuan Xia, Yuxi Zhang, Chong Dong, Chong Dong, Qian Sun, Shaoqing Lei

“…The ERDEGs diagnostic model was developed based on a combination of LASSO and Random Forest approaches, and the diagnostic performance was evaluated by the area under the receiver operating characteristic curve (ROC-AUC) and validated against external datasets. …”
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Enhanced thyroid nodule detection and diagnosis: a mobile-optimized DeepLabV3+ approach for clinical deployments by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…A high IoU value in medical imaging analysis reflects the model’s ability to accurately delineate object boundaries.ConclusionDeepLabV3+ represents a significant advancement in thyroid nodule segmentation, particularly for thyroid cancer screening and diagnosis. …”
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Prevention of Cardiometabolic Syndrome in Children and Adolescents Using Machine Learning and Noninvasive Factors: The CASPIAN-V Study by Hamid Reza Marateb, Mahsa Mansourian, Amirhossein Koochekian, Mehdi Shirzadi, Shadi Zamani, Marjan Mansourian, Miquel Angel Mañanas, Roya Kelishadi

“…We applied the XGBoost algorithm to analyze key noninvasive variables, including self-rated health, sunlight exposure, screen time, consanguinity, healthy and unhealthy dietary habits, discretionary salt and sugar consumption, birthweight, and birth order, father and mother education, oral hygiene behavior, and family history of dyslipidemia, obesity, hypertension, and diabetes using five-fold cross-validation. …”
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Health-Related Quality-of-Life Utility Values in Adults With Late-Onset Pompe Disease: Analyses of EQ-5D Data From the PROPEL Clinical Trial by Alison Griffiths, Simon Shohet, Neil Johnson, Alasdair MacCulloch

“…In PROPEL, EQ-5D-5L values were assessed at screening and at weeks 12, 26, 38, and 52. EQ-5D-5L utility values were mapped to EQ-5D-3L values using the van Hout algorithm as recommended by the EuroQoL and the National Institute of Health and Care Excellence position statement at time of analysis. …”
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Retinal Microvascular Characteristics—Novel Risk Stratification in Cardiovascular Diseases by Alexandra Cristina Rusu, Klara Brînzaniuc, Grigore Tinica, Clément Germanese, Simona Irina Damian, Sofia Mihaela David, Raluca Ozana Chistol

“…This study aims to identify the retinal microvascular features associated with CHDs and evaluate their potential use in a CHD screening algorithm in conjunction with traditional risk factors. …”
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Multimodal marvels of deep learning in medical diagnosis using image, speech, and text: A comprehensive review of COVID-19 detection by Md Shofiqul Islam, Khondokar Fida Hasan, Hasibul Hossain Shajeeb, Humayan Kabir Rana, Md. Saifur Rahman, Md. Munirul Hasan, AKM Azad, Ibrahim Abdullah, Mohammad Ali Moni

“…We explore the architecture of deep learning models, emphasising their data-specific structures and underlying algorithms. …”
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A reproducible approach for the use of aptamer libraries for the identification of Aptamarkers for brain amyloid deposition based on plasma analysis. by Cathal Meehan, Soizic Lecocq, Gregory Penner

“…Eight aptamers were identified as a result of the selection process and screened across 390 plasma samples by qPCR assay. Results were analysed using multiple machine learning algorithms from the Scikit-learn package along with clinical variables including cognitive status, age and sex to create predictive models. …”
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Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study by Yejing Zhao, Yejing Zhao, Xiang Wang, Jie Zhang, Yanyan Zhao, Yi Li, Ji Shen, Ying Yuan, Jing Li

“…To address this gap, datasets GSE29378 and GSE12685 were selected to screen differentially expressed genes (DEGs), and hub genes were identified by different algorithms. …”
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Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment by Chuanyu Ma, Chuanyu Ma, Guandu Li, Xiaohan Song, Xiaochen Qi, Tao Jiang

“…GO and KEGG pathway enrichment analyses were performed on these 103 positively correlated differentially expressed genes, and the proportion and type of tumour-infiltrating immune cells were assessed by TIMER, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, MCPCOUNTER, XCELL and EPIC algorithms in patients. In addition, we calculated the relevance of immunotherapy and predicted various drugs that might be used for treatment and evaluated the predictive power of survival models under multiple machine learning algorithms through the training set TCGA-PRAD versus the validation set PRAD-FR cohort. …”
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Effect of miR-200c on inducing autophagy and apoptosis of HT22 cells from mouse hippocampal neurons via regulating PRDM1 protein: a bioinformatics analysis by W. Wu, J. Fu, Q. Liu, Q. Wang, S. Gao, X. Deng, C. Shen

“…The Support Vector Machine (SVM) algorithm in the Weka software was used to process, model, and screen the available miRNA data. …”
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Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome by Ge Jin, Xiaomei Fan, Xiaoliang Liang, Honghong Dai, Jun Wang

“…The risk score model constructed based on these biomarkers could effectively predict the survival rate of cervical cancer patients (AUC >0.6 for 1/3/5 years). …”
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The Future of Minimally Invasive GI and Capsule Diagnostics (REFLECT), October 2024 by Lea Østergaard Hansen, Alexandra Agache, Anastasios Koulaouzidis

“…The symposium also highlighted the significance of predictive models for patient selection and developments in panenteric CE. …”
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Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches by Hu J, Chen Z, Wang J, Xu A, Sun J, Xiao W, Yang M

“…Subsequently, neuroinflammation-related genes were obtained to construct a neuroinflammation-related signature. The AddModuleScore algorithm was used to calculate neuroinflammation scores for each cell subpopulation, whereas the CellCall algorithm was used to assess the crosstalk between neutrophils and other cell subpopulations. …”
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