Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk by Ji-Eun Song, Ji Young Jang, Kyung Nam Kang, Ji Soo Jung, Chul Woo Kim, Ah Sol Kim

“…Breast cancer risk scores for each Breast Imaging-Reporting and Data System (BI-RADS) category in multi-microRNA analysis were analyzed to examine the correlation between breast cancer risk scores and mammography categories. We generated two models using two classification algorithms, SVM and GLM, with a combination of four miRNA biomarkers showing high performance and sensitivities of 84.5% and 82.1%, a specificity of 85%, and areas under the curve (AUCs) of 0.967 and 0.965, respectively, which showed consistent performance across all stages of breast cancer and patient ages. …”
Get full text

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells... by Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng

“…Notably, the expression levels of these three hub genes and the lactylation level of TUBB2A in GBM tissues were significantly higher compared to those in normal tissues.ConclusionsWe propose and validate a IQR lactylation screening method that provides potential insights for GBM therapy and an effective framework for developing gene screening models applicable to other diseases and pathogenic mechanisms.…”
Get full text

YOLO-RGDD: A Novel Method for the Online Detection of Tomato Surface Defects by Ziheng Liang, Tingting Zhu, Guang Teng, Yajun Zhang, Zhe Gu

“…Finally, dynamic convolution was used to replace the conventional convolution in the detection head in order to reduce the model parameter count. The experimental results show that the average precision, recall, and F1-score of the proposed YOLO-RGDD model for tomato defect detection reach 88.5%, 85.7%, and 87.0%, respectively, surpassing advanced object recognition detection algorithms. …”
Get full text

Technical Code Analysis of Geomagnetic Flaw Detection of Suppression Rigging Defect Signal Based on Convolutional Neural Network by Gang Zhao, Changyu Han, Zhongxiang Yu, Zhipan Li, Guoao Yu, Hongmei Zhang, Dadong Zhao, Zhengyi Jiang

“…The single-stage object detection algorithm YOLOv5 (You Only Look Once) based on convolutional neural network model calculation is used, the scale detection layer and positioning loss function of the YOLOv5 algorithm are improved and optimized, and the improved YOLOv5 algorithm is used for experiments. …”
Get full text

Iterative phase contrast CT reconstruction with novel tomographic operator and data-driven prior. by Stefano van Gogh, Subhadip Mukherjee, Jinqiu Xu, Zhentian Wang, Michał Rawlik, Zsuzsanna Varga, Rima Alaifari, Carola-Bibiane Schönlieb, Marco Stampanoni

“…Moreover, the highly ill-conditioned differential nature of the GI-CT forward operator renders the inversion from corrupted data even more cumbersome. In this paper, we propose a novel regularized iterative reconstruction algorithm with an improved tomographic operator and a powerful data-driven regularizer to tackle this challenging inverse problem. …”
Get full text

Leveraging diverse cell-death patterns to predict to predict prognosis and immunotherapy in hepatocellular carcinoma by Xiaoxiang Zhang, Dongxiao Ding, Dianqian Wang, Yunsheng Qin

“…Although many efforts have been made to improve the prognosis of LIHC, the situation is still dismal. …”
Get full text

Integrating status-neutral and targeted HIV testing in Zimbabwe: A complementary strategy. by Hamufare D Mugauri, Owen Mugurungi, Joconiah Chirenda, Kudakwashe Takarinda, Prosper Mangwiro, Mufuta Tshimanga

“…First tests were 65% more likely to test HIV positive (a95%CI: 1.43, 1.91) whilst screened patients were 3.89 times more likely to link to HIV prevention services (a95%CI: 3.05, 4.97), against 25.5% (n = 1,871) linkage among patients not screened.…”
Get full text

Machine Learning and Deep Learning Techniques for Prediction and Diagnosis of Leptospirosis: Systematic Literature Review by Suhila Sawesi, Arya Jadhav, Bushra Rashrash

“…MethodsUsing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS), and Prediction model Risk of Bias Assessment Tool (PROBAST) tools, we conducted a comprehensive review of studies applying ML and DL models for leptospirosis detection and prediction, examining algorithm performance, data sources, and validation approaches. …”
Get full text

Load identification method based on one class classification combined with fuzzy broad learning by Wang Yi, Wang Xiaoyang, Li Songnong, Chen Tao, Hou Xingzhe, Fu Xiuyuan

“…Considering the recognition rate and model complexity, the fuzzy broad learning system is used to classify and recognize the screened samples. …”
Get full text

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection by Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist

“…The C. diff Quik Chek Complete performed the best of the three immunoassays, and when used in combination with NAAT, is a viable option for the laboratory diagnosis of CDI.IMPORTANCELaboratory diagnosis of Clostridioides difficile infection is complex, and current guidelines recommend a two-step diagnostic algorithm with a sensitive screening test and a more specific confirmatory test. …”
Get full text

Evaluating the role of insulin resistance in chronic intestinal health issues: NHANES study findings by Dongyao Zhao, Meihua Zhao, Bing Gao, He Lu

“…Key variables were selected via the Boruta algorithm and incorporated into weighted multivariate logistic regression models. …”
Get full text

Development and validation of a 3-D deep learning system for diabetic macular oedema classification on optical coherence tomography images by Mingzhi Zhang, Tsz Kin Ng, Yi Zheng, Guihua Zhang, Jian-Wei Lin, Ji Wang, Jie Ji, Peiwen Xie, Yongqun Xiong, Hanfu Wu, Cui Liu, Huishan Zhu, Jinqu Huang, Leixian Lin

“…The deep learning (DL) performance was compared with the diabetic retinopathy experts.Setting Data were collected from Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Chaozhou People’s Hospital and The Second Affiliated Hospital of Shantou University Medical College from January 2010 to December 2023.Participants 7790 volumes of 7146 eyes from 4254 patients were annotated, of which 6281 images were used as the development set and 1509 images were used as the external validation set, split based on the centres.Main outcomes Accuracy, F1-score, sensitivity, specificity, area under receiver operating characteristic curve (AUROC) and Cohen’s kappa were calculated to evaluate the performance of the DL algorithm.Results In classifying DME with non-DME, our model achieved an AUROCs of 0.990 (95% CI 0.983 to 0.996) and 0.916 (95% CI 0.902 to 0.930) for hold-out testing dataset and external validation dataset, respectively. …”
Get full text

Evaluation of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease using ultrasound controlled attenuation parameter combined with clinical feat... by LIU Chunyu, TANG Jingkuan, ZHAO Wei

“…Features were selected using the Boruta algorithm, and a predictive model combining CAP and clinical features was constructed. …”
Get full text

Automated whole animal bio-imaging assay for human cancer dissemination. by Veerander P S Ghotra, Shuning He, Hans de Bont, Wietske van der Ent, Herman P Spaink, Bob van de Water, B Ewa Snaar-Jagalska, Erik H J Danen

“…Moreover, RNA interference establishes the metastasis-suppressor role for E-cadherin in this model. This automated quantitative whole animal bio-imaging assay can serve as a first-line in vivo screening step in the anti-cancer drug target discovery pipeline.…”
Get full text

Tool wear prediction based on XGBoost feature selection combined with PSO-BP network by Zhangwen Lin, Yankun Fan, Jinling Tan, Zhen Li, Peng Yang, Hua Wang, Weiwei Duan

“…Experimental results show that PSO outperforms other algorithms in training the tool wear prediction model, with XGBoost feature selection reducing model construction time by 57.4% and increasing accuracy by 63.57%, demonstrating superior feature selection capabilities over Decision Tree, Random Fores, Adaboost and Extra Trees. …”
Get full text

Optimizing deep learning for accurate blood cell classification: A study on stain normalization and fine-tuning techniques by Mohammed Tareq Mutar, Jaffar Nouri Alalsaidissa, Mustafa Majid Hameed, Ali Almothaffar

“…BACKGROUND: Deep learning’s role in blood film screening is expanding, with recent advancements including algorithms for the automated detection of sickle cell anemia, malaria, and leukemia using smartphone images. …”
Get full text

Efficient secure federated learning aggregation framework based on homomorphic encryption by Shengxing YU, Zhong CHEN

“…In order to solve the problems of data security and communication overhead in federated learning, an efficient and secure federated aggregation framework based on homomorphic encryption was proposed.In the process of federated learning, the privacy and security issues of user data need to be solved urgently.However, the computational cost and communication overhead caused by the encryption scheme would affect the training efficiency.Firstly, in the case of protecting data security and ensuring training efficiency, the Top-K gradient selection method was used to screen model gradients, reducing the number of gradients that need to be uploaded.A candidate quantization protocol suitable for multi-edge terminals and a secure candidate index merging algorithm were proposed to further reduce communication overhead and accelerate homomorphic encryption calculations.Secondly, since model parameters of each layer of neural networks had characteristics of the Gaussian distribution, the selected model gradients were clipped and quantized, and the gradient unsigned quantization protocol was adopted to speed up the homomorphic encryption calculation.Finally, the experimental results show that in the federated learning scenario, the proposed framework can protect data privacy, and has high accuracy and efficient performance.…”
Get full text

The impact of specialised gastroenterology services for pelvic radiation disease (PRD): Results from the prospective multi-centre EAGLE study. by John N Staffurth, Stephanie Sivell, Elin Baddeley, Sam Ahmedzai, H Jervoise Andreyev, Susan Campbell, Damian J J Farnell, Catherine Ferguson, John Green, Ann Muls, Raymond O'Shea, Sara Pickett, Lesley Smith, Sophia Taylor, Annmarie Nelson

“…All men completed a validated screening tool for late bowel effects (ALERT-B) and the Gastrointestinal Symptom Rating Score (GSRS); men with a positive score on ALERT-B were offered management following a peer reviewed algorithm for pelvic radiation disease (PRD). …”
Get full text

Research on Feature Extraction of Performance Degradation for Flexible Material R2R Processing Roller Based on PCA by Yaohua Deng, Huiqiao Zhou, Kexing Yao, Zhiqi Huang, Chengwang Guo

“…The Jacobi iteration method was introduced to derive the algorithm for solving eigenvalue and eigenvector of the covariance matrix. …”
Get full text

A machine learning approach to predict positive coronary artery calcium scores in individuals with diabetes: a cross-sectional analysis of ELSA-Brasil baseline data by J.L. Amorim, I.M. Bensenor, A.P. Alencar, A.C. Pereira, A.C. Goulart, P.A. Lotufo, I.S. Santos

“…We analyzed 25 sociodemographic, medical history, symptom-related, and laboratory variables from 585 participants from the São Paulo investigation center with CACS data and no overt cardiovascular disease at baseline. We used six ML algorithms to build models to identify individuals with positive CACS. …”
Get full text