Predicting Affinity Through Homology (PATH): Interpretable binding affinity prediction with persistent homology. by Yuxi Long, Bruce R Donald

“…Compared to current binding affinity prediction algorithms, PATH+ shows similar or better accuracy and is more generalizable across orthogonal datasets. …”
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Early breast cancer detection via infrared thermography using a CNN enhanced with particle swarm optimization by Riyadh M. Alzahrani, Mohamed Yacin Sikkandar, S. Sabarunisha Begum, Ahmed Farag Salem Babetat, Maryam Alhashim, Abdulrahman Alduraywish, N. B. Prakash, Eddie Y. K. Ng

“…An Enhanced Particle Swarm Optimization (EPSO) algorithm is integrated to automatically fine-tune CNN hyperparameters, thereby minimizing manual effort and enhancing computational efficiency. …”
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Golden eagle optimized CONV-LSTM and non-negativity-constrained autoencoder to support spatial and temporal features in cancer drug response prediction by Wesam Ibrahim Hajim, Suhaila Zainudin, Kauthar Mohd Daud, Khattab Alheeti

“…Advanced machine learning (ML) and deep learning (DL) methods have recently been utilized in Drug Response Prediction (DRP), and these models use the details from genomic profiles, such as extensive drug screening data and cell line data, to predict the response of drugs. …”
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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. by Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall

“…Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. …”
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Efficient evidence selection for systematic reviews in traditional Chinese medicine by Yizhen Li, Zhe Huang, Zhongzhi Luan, Shujing Xu, Yunan Zhang, Lin Wu, Darong Wu, Dongran Han, Yixing Liu

“…Methods We integrated an established deep learning model (Evi-BERT combined rule-based method) with Boolean logic algorithms and an expanded retrieval strategy to automatically and accurately select potential evidence with minimal human intervention. …”
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An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis by Dong Yue, Fengyun Dong, Sen Wang, Miao Zheng

“…The univariate Cox algorithm, LASSO, and multivariate Cox analysis were performed to obtain biomarkers and build a prognostic model. …”
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Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay by Anusha Klett, Anusha Klett, Dennis Raith, Dennis Raith, Paula Silvestrini, Paula Silvestrini, Paula Silvestrini, Matías Stingl, Jonas Bermeitinger, Avani Sapre, Avani Sapre, Avani Sapre, Martin Condor, Roman Melachrinos, Mira Kusterer, Alexandra Brand, Guido Pisani, Guido Pisani, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Marie Follo, Marie Follo, Jesús Duque-Afonso, Roland Mertelsmann, Roland Mertelsmann

“…Brightfield images were used to train a YOLOv8 object detection network, achieving a mAP50 score of 86% for identifying single cells, clusters, and colonies, and 97% accuracy for Z-stack colony identification with a multi-object tracking algorithm. The detection model accurately identified the majority of objects in the dataset.ResultsThis AI-assisted CFA was successfully applied for density optimization, enabling the determination of seeding densities that maximize plating efficiency (PE), and for IC50 determination, offering an efficient, less labor-intensive method for testing drug concentrations. …”
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Acoustic-based machine learning approaches for depression detection in Chinese university students by Yange Wei, Yange Wei, Shisen Qin, Fengyi Liu, Rongxun Liu, Yunze Zhou, Yuanle Chen, Xingliang Xiong, Wei Zheng, Guangjun Ji, Yong Meng, Fei Wang, Fei Wang, Ruiling Zhang

“…Among five machine learning algorithms, LDA model demonstrated the highest classification performance, with an AUC of 0.771. …”
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Leveraging diverse cell-death patterns in diagnosis of sepsis by integrating bioinformatics and machine learning by Mi Liu, Xingxing Gao, Hongfa Wang, Yiping Zhang, Xiaojun Li, Renlai Zhu, Yunru Sheng

“…The machine learning algorithm screened three PCD-related genes, NLRC4, TXN and S100A9, as potential biomarkers for sepsis. …”
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Machine learning-based ultrasound radiomics for predicting risk of recurrence in breast cancer by Wei Fan, Hao Cui, Xiaoxue Liu, Xudong Zhang, Xinran Fang, Junjia Wang, Zihao Qin, Xiuhua Yang, Jiawei Tian, Lei Zhang

“…The receiver operating characteristic (ROC), calibration, and decision curve analysis (DCA) curves were used to evaluate the model’s clinical applicability and predictive performance.ResultsA total of 12 ultrasound radiomics features were screened, of which wavelet.LHL first order Mean features weighed more and tended to have a high risk of recurrence. …”
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A machine learning framework for predicting cognitive impairment in aging populations using urinary metal and demographic data by Fengchun Ren, Xiao Zhao, Qin Yang, Huaqiang Liao, Yudong Zhang, Xuemei Liu

“…Ultimately, a user-friendly webserver was deployed for the predictive model and is freely accessed at http://bio-medical.online/admxp/.DiscussionThe associated webserver enables accessible risk screening and underpins precision prevention strategies in aging populations.…”
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Empowering Healthcare: TinyML for Precise Lung Disease Classification by Youssef Abadade, Nabil Benamar, Miloud Bagaa, Habiba Chaoui

“…These findings highlight the potential of TinyML to provide accessible, reliable, and real-time diagnostic tools, particularly in remote and underserved areas, demonstrating the transformative impact of integrating advanced AI algorithms into portable medical devices. This advancement facilitates the prospect of automated respiratory health screening using lung sounds.…”
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Optimized Allocation of Flood Control Emergency Materials Based on Loss Quantification by Wei Wang, Yunqing Wang, Li Huang, Yue Song

“…The center of gravity method is used to address demand when constructing the quantitative function of out‐of‐stock loss. The NSGA‐II algorithm was selected to generate the results after the method comparison to ultimately determine the Pareto solution of the model. …”
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Optimizing the dynamic treatment regime of outpatient rehabilitation in patients with knee osteoarthritis using reinforcement learning by Sijia Liu, Jiawei Luo, Chengqi He

“…Then, based on the key features screened out, a dynamic treatment recommendation system was constructed by using deep reinforcement learning algorithms, including Deep Deterministic Policy Gradien(DDPG), Deep Q-Network(DQN) and Batch-Constrained Q-learning(BCQ). …”
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Mitochondrial-Localized Protein Transcript Abundance can Predict the Prognosis of Endometrial Carcinoma: A Retrospective Analysis by Weifei Liang, Hong Lin, Donglin Sun, Minghui Tang

“…Moreover, a nomogram was constructed through the combination of the scoring algorithm and the patient’s clinical features. Conclusions: The scoring algorithm based on mitochondrial gene expression can assist clinicians in predicting the postoperative survival rate of patients, allowing them to devise more precise treatment programs.…”
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Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis by Hamed Hajishah, Danial Kazemi, Ehsan Safaee, Mohammad Javad Amini, Maral Peisepar, Mohammad Mahdi Tanhapour, Arian Tavasol

“…In total, 346 machine learning models were evaluated, with the most common algorithms being random forest, logistic regression, and gradient boosting. …”
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Implementation costs and cost-effectiveness of ultraportable chest X-ray with artificial intelligence in active case finding for tuberculosis in Nigeria. by Tushar Garg, Stephen John, Suraj Abdulkarim, Adamu D Ahmed, Beatrice Kirubi, Md Toufiq Rahman, Emperor Ubochioma, Jacob Creswell

“…We provide implementation cost and cost-effectiveness estimates of different screening algorithms using symptoms, CXR and AI in Nigeria. …”
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Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches by Hu J, Chen Z, Wang J, Xu A, Sun J, Xiao W, Yang M

“…Subsequently, neuroinflammation-related genes were obtained to construct a neuroinflammation-related signature. The AddModuleScore algorithm was used to calculate neuroinflammation scores for each cell subpopulation, whereas the CellCall algorithm was used to assess the crosstalk between neutrophils and other cell subpopulations. …”
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Machine Learning and Interpretability Study for Predicting 30-Day Unplanned Readmission Risk of Schizophrenia: A Retrospective Study by Tan Y, Chen G, Wang S, Zhan X, Cheng R, Qiao L, Zhang Z, Liu Y

“…Models were constructed after screening variables using the multiple linear regression and feature importance methods. …”
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Enhanced thyroid nodule detection and diagnosis: a mobile-optimized DeepLabV3+ approach for clinical deployments by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…A high IoU value in medical imaging analysis reflects the model’s ability to accurately delineate object boundaries.ConclusionDeepLabV3+ represents a significant advancement in thyroid nodule segmentation, particularly for thyroid cancer screening and diagnosis. …”
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