Generative and predictive neural networks for the design of functional RNA molecules by Aidan T. Riley, James M. Robson, Aiganysh Ulanova, Alexander A. Green

“…We pair these predictive models with generative adversarial RNA design networks (GARDN), allowing the generative modelling of a diverse range of functional RNA molecules with targeted experimental attributes. …”
Get full text

Cysticercosis in Madagascar by Jean-François Carod, Pierre Dorny

“…Neurocysticercosis (NCC) is the most common pattern of cysticercosis in Madagascar and it is reponsible for pediatric morbidity causing more than 50% of epilepsy cases. Though CT-Scan is now available and tends to be considered the gold standard for NCC diagnosis, it remains unaffordable for most Malagasy patients and implies the proposal of a diagnostic algorithm for physicians. …”
Get full text

Comprehensive integration of diagnostic biomarker analysis and immune cell infiltration features in sepsis via machine learning and bioinformatics techniques by Liuqing Yang, Liuqing Yang, Liuqing Yang, Rui Xuan, Rui Xuan, Rui Xuan, Dawei Xu, Dawei Xu, Dawei Xu, Aming Sang, Aming Sang, Aming Sang, Jing Zhang, Jing Zhang, Jing Zhang, Yanfang Zhang, Xujun Ye, Xinyi Li, Xinyi Li, Xinyi Li

“…The utilization of the receiver operating characteristic curve in conjunction with the nomogram model served to authenticate the discriminatory strength and efficacy of the key genes. …”
Get full text

Research on implementation of interventions in tuberculosis control in low- and middle-income countries: a systematic review. by Frank Cobelens, Sanne van Kampen, Eleanor Ochodo, Rifat Atun, Christian Lienhardt

“…Evaluations of diagnostic and screening algorithms were more frequent (n = 19) but geographically clustered and mainly of non-comparative design. …”
Get full text

Helicobacter pylori eradication treatment for gastric carcinoma prevention in asymptomatic or dyspeptic adults: systematic review and Bayesian meta-analysis of randomised controlle... by Teruhiko Terasawa, Isao Miyashiro, Katsuaki Kato, Takaki Yoshikawa, Reo Takaku, Hiroshi Nishida

“…However, concerns about supporting unfocused screening and eradication programme in healthy, asymptomatic populations have arisen. …”
Get full text

APPLICATION OF NEURAL NETWORKS IN DIAGNOSTICS OF BREAST CANCER ACCORDING TO THE DATA OF MICROWAVE RADIO THERMOMETRY by A. Losev, D. Medvedev

“…However, the analysis of microwave radiothermometry data is a very complex task, which prevents the widespread use of this method in screening. This problem can be solved by creating an effective expert system based on the use of mathematical and computer modeling methods, the capabilities of modern information technologies and, above all, machine learning algorithms. …”
Get full text

Project quality, regulation quality by Elena Mussinelli

“…These tools legitimise choices where conformity to the standard acts as a screen for the assumption of precise responsibilities. …”
Get full text

Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

“…We show that an algorithmic approach (Fragmenstein) that ‘stitches’ the ligand atoms from this structural information together can provide more accurate and reliable predictions for protein–ligand complex conformation than general methods such as pharmacophore-constrained docking. …”
Get full text

Active Learning for Medical Article Classification with Bag of Words and Bag of Concepts Embeddings by Radosław Pytlak, Paweł Cichosz, Bartłomiej Fajdek, Bogdan Jastrzębski

“…Systems supporting systematic literature reviews often use machine learning algorithms to create classification models to assess the relevance of articles to study topics. …”
Get full text

Artificial intelligence in breast oncology by Alexander Mundinger

“…Abstract Artificial intelligence (AI) is based on complex artificial neural networks, characterized by layered network architecture, parallel processing of large data sets and iterative algorithms for processing large data sets. AI-assisted screening studies have demonstrated non-inferior diagnostic performance, reduced human workload by up to 70%, and reduced recall rates by 25% compared to human double reading. …”
Get full text

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs: A WEB prediction approach. by Huaichuan Duan, Quanshan Shi, Xinru Yue, Zelan Zhang, Ling Liu, Yueteng Wang, Yujie Cao, Zuoxin Ou, Li Liang, Jianping Hu, Hubing Shi

“…Here, we first summarized and improved the open reading frame information of monkeypox, constructed the monkeypox inhibitor library and potential targets library by database research as well as literature search, combined with advanced protein modeling technologies (Sequence-based and AI algorithms-based homology modeling). …”
Get full text

Neutrophil- and Endothelial Cell-Derived Extracellular Microvesicles Are Promising Putative Biomarkers for Breast Cancer Diagnosis by Thayse Batista Moreira, Marina Malheiros Araújo Silvestrini, Ana Luiza de Freitas Magalhães Gomes, Kerstin Kapp Rangel, Álvaro Percínio Costa, Matheus Souza Gomes, Laurence Rodrigues do Amaral, Olindo Assis Martins-Filho, Paulo Guilherme de Oliveira Salles, Letícia Conceição Braga, Andréa Teixeira-Carvalho

“…Machine learning approaches were employed to determine the performance of MVs to identify BC and to propose BC classifier algorithms. <b>Results:</b> Patients with BC had more neutrophil- and endothelial cell-derived MVs than controls before treatment. …”
Get full text

Artificial intelligence applications in pediatric ophthalmology: A comprehensive review by Anupama Janardhanan, Meenakshi Ravindran, Allapitchai Fathima, Neelam Pawar

“…Furthermore, it explores existing AI models and their applicability in diagnosing refractive errors and strabismus. …”
Get full text

Progress on the application of supercomputer brain simulation technology by SUN Zhe

“…This review examines the theoretical principles and technical foundations of supercomputer brain simulation, including distributed parallel algorithms, graphics processing unit (GPU)⁃based acceleration, and multimodal data management. …”
Get full text

Gaussian Process Regression and Machine Learning Methods for Carbon-Based Material Adsorption by Manar Ahmed Hamza, Maha M. Althobaiti, Fahd N. Al-Wesabi, Rana Alabdan, Hany Mahgoub, Anwer Mustafa Hilal, Abdelwahed Motwakel, Mesfer Al Duhayyim

“…., warmth, solution pH) and adsorbent varieties, the created Ml algorithms outperformed classic isotherm models in conditions of generalisation. …”
Get full text

Proteomic analysis of blood plasma as a tool for personalized diagnosis of lung adenocarcinoma by D. N. Korobkov, A. S. Kononikhin, S. D. Semenov, H. L. Kordzaya, A. G. Brzhozovskiy, A. E. Bugrova, E. Yu. Vasilieva, D. Yu. Kanner, E. N. Nikolaev, A. A. Komissarov

“…Classifiers developed based on these protein panels make it possible to distinguish between patients with LAC and healthy controls, as well as to detect the presence of metastases among patients with LAC, with sensitivity and specificity of more than 90 %.Conclusion. The data obtained can be used to develop new tests for LAC screening and predicting disease outcomes based on the blood plasma proteome. …”
Get full text

Deaths ascribed to non-communicable diseases among rural Kenyan adults are proportionately increasing: evidence from a health and demographic surveillance system, 2003-2010. by Penelope A Phillips-Howard, Kayla F Laserson, Nyaguara Amek, Caryl M Beynon, Sonia Y Angell, Sammy Khagayi, Peter Byass, Mary J Hamel, Anne M van Eijk, Emily Zielinski-Gutierrez, Laurence Slutsker, Kevin M De Cock, John Vulule, Frank O Odhiambo

“…<h4>Background</h4>Non-communicable diseases (NCDs) result in more deaths globally than other causes. Monitoring systems require strengthening to attribute the NCD burden and deaths in low and middle-income countries (LMICs). …”
Get full text

Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis by Ivars Neiders, Signe Mežinska, Neeltje E. M. van Haren

“…First, there are issues that should deserve more attention than they have received thus far (clinical utility, extensive or mandatory use). …”
Get full text

Amyloid Cardiomyopathy: Review of A Fatal Case Report by O. V. Soldatova, I. Ya. Goryanskaya

“…To date, it has been proven that amyloid cardiomyopathy is an important and often undiagnosed cause of chronic heart failure and cardiac arrhythmias, especially in the elderly. There are more than 15 types of precursor proteins capable of causing systemic amyloidosis, but only 2 of them accumulate in the interstitium of the heart: light chains of clonal immunoglobulin (AL) and tetrameric protein transthyretin (TTR). …”
Get full text

EDUCATIONAL TRAINING SIMULATOR FOR MONITORING READING TECHNIQUE AND SPEED BASED ON SPEECH-TO-TEXT (STT) METHODS by Olesia Barkovska, Heorhii Ivashchenko, Dmytro Rosinskiy, Daniil Zakharov

“…The results of testing children with dyslalia, meaning the rearrangement of sounds in words when reading, also showed that the Jaro algorithm has a shorter line comparison time for large text arrays (by 7%). …”
Get full text