The Dynamical Asymmetry in SARS-CoV2 Protease Reveals the Exchange Between Catalytic Activity and Stability in Homodimers by Velia Minicozzi, Alessandro Giuliani, Giampiero Mei, Leonardo Domenichelli, Mauro Parise, Almerinda Di Venere, Luisa Di Paola

“…The molecular approach to understanding the mechanisms of emerging diseases, like COVID-19, has largely accelerated the search for successful therapeutical strategies. In this work, we present an extensive molecular dynamics (MD) analysis of two forms of the SARS-CoV-2 main protease M^Pro. …”
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Experience of Parenteral Administration of Methotrexate in a Female Patient Suffering from Early Juvenile Idiopathic Arthritis and Uveitis by Т. V. Sleptsova, Е. I. Alexeeva, Т. М. Bzarova, S. I. Valieva, R. V. Denisova, K. B. Isaeva, Е. G. Chistyakova, А. М. Chomakhidze, N. I. Taybulatov

“…At the initial stage of treatment, the child demonstrated severe articular syndrome, inflammatory reactions affecting eyeball surfaces, increased laboratory indicators of the illness and functional insufficiency. Successful overcoming of methotrexate resistance through dosage increased up to 20 mg/m2 of body surface per week was described. …”
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Fine‐Tuning Porous Structure of Zirconium‐Based Metal–Organic Frameworks for Efficient Separation and Purification of Astaxanthin by Defect Engineering by Xin Na, Shanghua Xing, Mingqian Tan, Wentao Su

“…Abstract Efficient separation of bioactive compounds from nature source, particularly that of astaxanthin (AXT), remains challenging due to their low content in complicated matrix and readily degradable structure. …”
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Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors by I. V. Maev, D. S. Bordin, E. V. Barkalova, M. A. Ovsepyan, E. R. Valitova, N. G. Kalashnikova, D. N. Andreev

“…Evaluation of the results of high-resolution esophageal manometry showed that violations of the structure and function of the esophago-gastric junction were detected in 21 patients out of 52. …”
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Peculiarities of Modeling a Specialized Computing System by G. A. Zvonareva, D. S. Buzunov

“…During the construction of the simulation model of the system a specialized data acquisition device as source of requests; a switch for which a request queue with different priorities is simulated; a data processing device, which is the final recipient of the data were selected as simulation functional nodes.The types of algorithms used to solve the request prioritization problem are taken from common prioritization algorithms typical for the Quality of Service (QoS), used in modern switching equipment. …”
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A Combined Experimental and First-Principle Calculation (DFT Study) for In Situ Polymer Inclusion Membrane-Assisted Growth of Metal-Organic Frameworks (MOFs) by Reza Darvishi, Esmaeil Pakizeh

“…A simple yet effective strategy was developed to prepare a metal-organic framework- (MOF-) based asymmetric membrane by depositing the Zeolitic imidazolate framework-8 (Zif-8) layer on the aminosilane-functionalized surface of a polymer inclusion membrane via an in situ growth process. …”
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Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar by Shangong Tong, Wenlong Li, Yuandong Rao, Yanqin Xiao, Yingyin Yan, Weiling Guo, Xucong Lü, Jinyuan Sun, Lianzhong Ai, Li Ni

“…This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar, and explore the core functional microbes closely related to the formation of flavor components. …”
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Phage therapy in antibiotic resistant pneumonia: immunomodulation or redistribution? by S. S. Bochkareva, I. M. Fedorova, O. N. Ershova, S. I. Koteleva, I. V. Kapustin, M. S. Blyakher, L. I. Novikova, A. V. Aleshkin, А. М. Vorobev

“…Statistical processing of the results was carried out using the Statistica 6 program according to the nonparametric Mann-Whitney U-test. In the course of successful phage therapy with individually selected bacteriophages overcoming of lymphopenia (if there was one) and an increase in both the number and functional activity of peripheral blood lymphocytes in all patients with pneumonia observed are noted. …”
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Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model by Daumante Suminaite, Nurul Fatihah Talib, Sophie Jane Pettegree, Han Chew Gaelan Tan, Yvonne Louise Odey, Emma Margaret Perkins, Alastair Robert Lyndon, Paul Andrew Skehel, Mandy Jackson

“…Here the CatWalk XT system was successful in detecting differences in both truncal stability and interlimb coordination across the disease course of β-III−/− mice. …”
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Methods for synthesis of matching circuits for broadband radio devices with unstable load impedance by I. A. Dubovik, P. V. Boykachev, V. O. Isaev, A. A. Dmitrenko

“…The aim of this work is to select a synthesis method for a broadband matching circuit that provides maximum power transfer from a signal source to a load in the presence of a changing load impedance of a radio engineering device. …”
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Transforming Library and Higher Education Services in Support of Industrialization and Modernization by G. Kabatangare, Tumuhairwe

“…The research design was of a descriptive survey nature based on a critical analytical literature review methodology sourcing relevant purposively sampled literature from Library and Information Science (LIS) data bases and the world-wide-web for grey literature using a purposively selected higher education academic library service provider target population. …”
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Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. It plays a key role in tumor growth by governing gene expression. …”
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Establishment of a New Hyperglycemic Obesity Cardiac Dysfunction Mouse Model with Triacsin C by ZHAO Xiaona, WANG Peng, YE Maoqing, QU Xinkai

“…The models were considered successful if fasting blood glucose exceeded 8 mmol/L or blood glucose was above 15 mmol/L two hours after glucose injection. …”
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Optimal selection of diagnostic method for diabetes mellitus using complex bipolar fuzzy dynamic data by Hanan Alolaiyan, Maryam Liaqat, Abdul Razaq, Umer Shuaib, Abdul Wakil Baidar, Qin Xin

“…We formulate a modified score function to address the shortcomings of the current score function in the CBF settings. …”
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Gene Network Biological Validity Based on Gene-Gene Interaction Relevance by Francisco Gómez-Vela, Norberto Díaz-Díaz

“…Finally, the ability of GeneNetVal to detect biological functionality of the network is shown.…”
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Mechanically flexible mid-wave infrared imagers using black phosphorus ink films by Theodorus Jonathan Wijaya, Naoki Higashitarumizu, Shifan Wang, Shogo Tajima, Hyong Min Kim, Shu Wang, Dehui Zhang, James Bullock, Tomoyuki Yokota, Takao Someya, Ali Javey

“…Leveraging this flexibility, we achieve full-azimuthal imaging, detecting directional light sources with precision. …”
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Establishment of human periodontal ligament cell lines with ALPL mutations to mimic dental aspects of hypophosphatasia by Jana Schiffmaier, Jana Schiffmaier, Sofia Rehling, Sofia Rehling, Katharina Marnet, Katharina Marnet, Angela Borst, Drenka Trivanović, Drenka Trivanović, Drenka Trivanović, Denitsa Docheva, Franz Jakob, Stephanie Graser, Marietta Herrmann, Daniel Liedtke

“…The detected variants either result in mis-splicing of ALPL mRNAs or in frameshift mutations. …”
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A dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq by Mailin Gan, Yuhang Lei, Kai Wang, Yan Wang, Tianci Liao, Jianfeng Ma, Li Zhu, Linyuan Shen

“…In this study, we utilized Pandora-seq technology to detect the small non-coding RNAs (sncRNAs) expression profile in the testicular tissue of heat-stressed mice. …”
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Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage by Natalia Lazzarin, Costanzo Moretti, Giovanna De Felice, Elena Vaquero, Dario Manfellotto

“…Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.…”
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Characterization of sacha inchi (Plukenetia volubilis) and taro (Colocasia esculenta) flours with potential application in the preparation of both gluten-free and high protein food... by Jesús Eduardo Bravo Gómez, Ruby Aracely Narváez Cadena, Angie Paola Salas Zambrano, Karen Sofia Muñoz Pabon, Diego Fernando Roa-Acosta

“…Staphylococcus aureus and Salmonella spp. were detected in taro flour. Conclusions Taro and sacha inchi flours have great potential for the development of functional products like protein snacks, with good expansion due to taro starch and are naturally gluten-free, making them suitable for people with celiac disease.…”
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