Ageing well in the urban environment: meeting the health and social needs of older Adults - study protocol for a prospective, longitudinal mixed-methods study by Marie Bolster, Abhijit Visaria, David Matchar, Denis Gerstorf, Tillman Schmitz, Benjamin Labohm, Raphael Kohl, Dagmar Haase, Paul Gellert, Angelique Chan, Wolfram J. Herrmann

“…Additionally, three functional tests (cognitive functioning, hand grip strength, and walking speed) are carried out with participants. …”
Get full text

Antioxidant and Anti-Inflammatory Activities of Cutlassfish Head Peptone in RAW 264.7 Macrophages by Su-Jin Lee, Jeonghyeon Im, Svini Dileepa Marasinghe, Eunyoung Jo, Minthari Sakethanika Bandara, Youngdeuk Lee, Jaewon Lee, Gun-Hoo Park, Chulhong Oh

“…CP suppressed the expression of inflammatory mediators, including inducible nitric oxide synthase (iNOS) and cyclooxygen-ase-2, and selectively inhibited the pro-inflammatory cytokines interleukin (IL)-1β and IL-6. …”
Get full text

Senegalin-2: A Novel Hexadecapeptide from <i>Kassina senegalensis</i> with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a Bradykinin Antagonist by Yueyang Lu, Yanguo Zhu, Chengbang Ma, Lei Wang, Mei Zhou, Tianbao Chen, Xiaonan Ma, Xu Zhang, Zhimin Fan

“…The amphibian skin secretions are excellent sources of bioactive peptides, some of which and their derivatives exhibit multiple properties, including antibacterial and antagonism against bradykinin. …”
Get full text

A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids by Sophia R. Meyer, Charles J. Zhang, Max A. Garcia, Megan C. Procario, Sanghee Yoo, Amber L. Jolly, Sumin Kim, Jiho Kim, Kyusuk Baek, Roland D. Kersten, Robert J. Fontana, Jonathan Z. Sexton

“…Results: The Curiochips successfully maintained liver physiology and function, showing strong albumin secretion and cytochrome (CYP) P450 activities for 28 days. …”
Get full text

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…In this study, we identified and characterized a novel covS single nucleotide polymorphism detected in three separate invasive M1UK isolates. …”
Get full text

Targeted proteomics for absolute quantification of glucose transporter 1 in mammalian brain cells using liquid chromatography-mass spectrometry by Yash Mehta, Dhavalkumar Patel, Iqra Pervaiz, Ulrich Bickel, Abraham Jacob Al-Ahmad

“…Glucose represents a major source of energy for mammalian brains. Its uptake is tributary to a functional glucose transporter (GLUT1) expression at the blood-brain barrier (BBB). …”
Get full text

Identification of the MADS-Box Gene Family and Development of Simple Sequence Repeat Markers in <i>Chimonanthus praecox</i> by Huafeng Wu, Bin Liu, Yinzhu Cao, Guanpeng Ma, Xiaowen Zheng, Ximeng Yang, Qianli Dai, Hengxing Zhu, Haoxiang Zhu, Xingrong Song, Shunzhao Sui

“…MADS-box genes encode transcription factors essential for plant growth and development, with key functions in regulating flowering time and the formation of floral organs. …”
Get full text

ORGANIZING THE WORK OF THE DONOR BREAST MILK BANK AT THE LVIV PERINATAL CENTER IS AN EXPERIENCE THAT MOTIVATES FURTHER DEVELOPMENT by М. Малачинська, М. Кісельова, О. Шлемкевич, Н. Вереснюк, Г. Коваленко

“… Human milk is considered the primary source of nutrition for breastfed infants and is justifiably regarded as the “gold standard.” …”
Get full text

AN INFLUENCE OF SPONTANEOUS MICROFLORA OF FERMENTED HORSEMEAT PRODUCTS ON THE FORMATION OF BIOLOGICALLY ACTIVE PEPTIDES by I. M. Chernukha, I. N. Nikonov, N. G. Mashentseva, D. L. Klabukova, D. A. Afanasev, L. I. Kovalyov, L. А. Ilina

“…Therefore, in the studied product, good preservation of the main spectra of muscle proteins was observed, and the identified fractions, apparently, can be sources of new functional peptides. Not only quantitative but also qualitative changes were observed in the studied samples. …”
Get full text

Assembly and Analysis of the Mitochondrial Genome of <i>Hippophae rhamnoides</i> subsp. <i>sinensis</i>, an Important Ecological and Economic Forest Tree Species in China by Jie Li, Song-Song Lu, Yang Bi, Yu-Mei Jiang, Li-Dan Feng, Jing He

“…Moreover, 31 chloroplast-derived fragments were detected, accounting for 11.86% of the mitochondrial genome length. …”
Get full text

Can machine-learning algorithms improve upon classical palaeoenvironmental reconstruction models? by P. Sun, P. B. Holden, H. J. B. Birks, H. J. B. Birks

“…<p>Classical palaeoenvironmental reconstruction models often incorporate biological ideas and commonly assume that the taxa comprising a fossil assemblage exhibit unimodal response functions of the environmental variable of interest. …”
Get full text

Mesangial cell-derived CircRNAs in chronic glomerulonephritis: RNA sequencing and bioinformatics analysis by Ji Hui Fan, Xiao Min Li

“…Pro-inflammatory cytokines and cell cycle stages were detected by Enzyme-linked immunosorbent assay (ELISA) and Flow Cytometry experiment, respectively. …”
Get full text

Fe foam supported FeVO4 nanoparticles for electrochemical nitrogen fixation at ambient conditions by Abdulmalik Aminu, Bilal Masood Pirzada, Shamraiz Hussain Talib, Janah Shaya, Ibrahim Yildiz, Sharmarke Mohamed, Ahsanulhaq Qurashi

“…Despite its attractive potential, the activity and efficiency of conventional e-NRR catalysts are still a major concern due to low selectivity and poor ammonia yields. Inspired by the FeFe and FeV cofactors present in nitrogenases, this study reports the synthesis and electrocatalytic evaluation of FeVO4 catalyst for N2 reduction. …”
Get full text

Feedback of patient-reported outcomes to healthcare professionals for comparing health service performance: a scoping review by Dominique A Cadilhac, Shaun L Hancock, Olivia F Ryan, Violet Marion, Sharon Kramer, Paulette Kelly, Sibilah Breen

“…Therefore, the aim of this scoping review was to summarise the emerging approaches to PROs data for ‘service-level’ feedback to healthcare professionals.Setting Healthcare professionals receiving PROs data feedback at the health-service level.Data sources Databases selected for the search were Embase, Ovid Medline, Scopus, Web of Science and targeted web searching. …”
Get full text

A Study on the Influence Mechanisms of Neighborhood Vitality and the Characteristics of Spatial and Temporal Differentiation in the Urban Fringe Areas of Wuhan City by Yan Long, Siyu Hu, Zhengyuan Lu, Lianghao Cheng, Cairui Zhen, Jingmei Shao, Yuqiao Zheng, Xuehui Zhou, Jin Li, Yudi Lin, Shu Zhang, Yue Wang, Tianyue Luo, Haijuan Zhao, Xuejun Liu

“…This paper quantifies the neighborhood vitality of the fringe areas by the short-stay visitors in the fringe areas and selects the 5D elements of the built environment and social media data from multiple sources to construct the indicator system assessing the neighborhood vitality of the urban fringe areas. …”
Get full text

Risk factors for fear of falling in stroke patients: a systematic review and meta-analysis by Li Ma, Qi Xie, Juhong Pei, Ling Gou, Yabin Zhang, Juanping Zhong, Yujie Su, Xinglei Wang, Xinman Dou

“…Therefore, we systematically reviewed the literature on risk factors for FoF in patients with stroke.Design A systematic review and meta-analysisData sources PubMed, Embase, Cochrane Library database, Web of Science, CINAHL, PsycINFO, Grey literature and other relevant databases for related publications were searched (from inception to 17 July 2021).Results Eight studies involving 1597 participants were selected to analyse risk factors for patients with stroke with FoF. …”
Get full text

Creation of Souvenir Products as a Means of Promotion of Historical and Cultural Heritage of the City by Uliana P. Efremova, Olga A. Tsesevichene, Anastasia A. Seldusheva

“…The methodological basis of the project was theoretical research methods, such as: analysis used to identify and clarify the target audience of the project, and select similar examples, as well as the souvenir market to highlight competitive advantages; synthesis - to identify optimal design solutions and formulate conclusions; comparison - to work with information sources when determining the functionality of the souvenir and its application. …”
Get full text

Effect of discontinuing antipsychotic medications on the risk of hospitalization in long-term care: a machine learning-based analysis by Mikko Nuutinen, Riikka-Leena Leskelä, Daniela Fialova, Ira Haavisto, Harriet Finne-Soveri, Jokke Häsä, Johanna Edgren, Hein van Hout, Daniel E. da Cunha Leme, John P. Hirdes, Graziano Onder, Rosa Liperoti

“…The use of restraints, age, and functional impairment were relevant variables in all ITE models in influencing the predicted ITE. …”
Get full text

GEANT4 Simulation of Proton Beam Properties from a Cyclotron Accelerator at King Chulalongkorn Memorial Hospital by Piyanud Thongjerm, Ekkachai Kongmon, Khwanjira Tangpong, Phalakorn Khwansungnoen, Sarinrat Wonglee, Weerawat Pornroongruengchok, Nantanat Chailanggar

“…The 80%–20% distal fall-off obtained from the simulation was used to determine the energy spread for each selected energy by matching the depth-dose peak with the measurement data. …”
Get full text

Distinct microbial communities drive methane cycling in below- and above-ground compartments of tropical cloud forests growing on peat by Fahad Ali Kazmi, Ülo Mander, Ramita Khanongnuch, Maarja Öpik, Reti Ranniku, Kaido Soosaar, Mohit Masta, Salla A. M. Tenhovirta, Kuno Kasak, Claudine Ah-Peng, Mikk Espenberg

“…However, no CH4-cycling functional genes were detected in the stem core samples. …”
Get full text