A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study by Tessa Ohlsen, Viola Hofer, Josef Ingenerf

“…Additionally, 868 OncoTree codes were evaluated, resulting in 161 (20.9%) PCEs containing inactive concepts, which were successfully replaced with valid alternatives. A user survey reflects a favorable evaluation of the tool’s functionality. …”
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Direct mosquito feedings on dengue-2 virus-infected people reveal dynamics of human infectiousness. by Louis Lambrechts, Robert C Reiner, M Veronica Briesemeister, Patricia Barrera, Kanya C Long, William H Elson, Alfonso Vizcarra, Helvio Astete, Isabel Bazan, Crystyan Siles, Stalin Vilcarromero, Mariana Leguia, Anna B Kawiecki, T Alex Perkins, Alun L Lloyd, Lance A Waller, Uriel Kitron, Sarah A Jenkins, Robert D Hontz, Wesley R Campbell, Lauren B Carrington, Cameron P Simmons, J Sonia Ampuero, Gisella Vasquez, John P Elder, Valerie A Paz-Soldan, Gonzalo M Vazquez-Prokopec, Alan L Rothman, Christopher M Barker, Thomas W Scott, Amy C Morrison

“…Magnitude of viremia is the primary determinant of successful human-to-mosquito DENV transmission. People with the same level of viremia, however, can vary in their infectiousness to mosquitoes as a function of other factors that remain to be elucidated. …”
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Reduced Concentrations of NSE, S100β, Aβ, and Proinflammatory Cytokines in Elderly Patients Receiving Ultrasound-Guided Combined Lumbar Plexus-Sciatic Nerve Block during Hip Replac... by Yi Zhang, Liya Jiang, Yang Han

“…Hemodynamic monitoring including pulse oxygen saturation (SpO2), heart rate and blood pressure, the assessment of pain intensity using Visual Analogue Scale (VAS), cognitive function assessment through Montreal Cognitive Assessment (MoCA) and biomarkers consisting of serum levels of neuron specific-enolase (NSE), S100 beta protein (S100-β), and amyloid beta protein (Aβ), as well as immune function by interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hs-CRP) were detected in this study. …”
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Predictive model for coronavirus disease 2019 severity based on blood biomarkers: a retrospective study by Liu Xiaoyan, Bao Zhongying, Duan Shuhong, Sun Jing, Zhang Yijie, Zhang Jie, Liu Jingxin

“…Emergency department data functioned as an independent external validation set to test the model’s generalizability.ResultsThe study included 1,007 patients, with 778 in the training set and 229 in the validation set. …”
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Coenzyme Q10 protects keratinocytes against oxidation-induced energy stress as revealed by spatiotemporal analysis of cell energetics by Roland Abi Nahed, Ali Hussein, Cécile Cottet-Rousselle, Alexandra Vogelsang, Francesco Aulicino, Imre Berger, Thomas Blatt, Julia M. Weise, Uwe Schlattner

“…We successfully established HaCaT cells stably expressing AMPfret, validated their functionality by inducing energy stress with 2-deoxy-D-glucose, and demonstrated that Q10, together with high glucose conditions in culture, can enhance cellular energetics compared to low glucose controls. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. …”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…In this study, we took advantage of the use of EBVs as a metric for GIN resistance in a case-control genome-wide framework and successfully identified several genomic regions that might be involved in the trait. …”
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Feasibility of in vivo small animal imaging using a clinical total-body PET/CT system by Julia G. Mannheim, Wenhong Lan, Maurizio Conti, Franziska Siedler, Marcel A. Krueger, Kristina Herfert, Christian la Fougère, Fabian P. Schmidt

“…No substantial position-dependent effects were detected in the phantom or single-mouse scan across the axial FOV. …”
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Effect of yellow capsicum extract on the lipid metabolism in mice by CUI Xiaoman, YU Haining, XU Jielan, CHEN Zhongting, SHEN Shengrong

“…In the end, the mice were killed and dissected, body fat percentage, contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and leptin in serum, expression levels of TC, TG, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the liver, were all detected and analyzed. Besides, the pancrelipase (PL) level of pancreatic tissue was also detected through ELISA method, as it is an important lipase in lipids metabolism.The results showed that, after 40 days' treatment through hyperlipidic diet, the obesity model group was successfully built up, as they were overweighed (P<0.01) and showed a higher mass of adipose tissue (P<0.05), TC (P<0.05), TG (P<0.01) contents than the normal diet control group. …”
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Cytotoxicity to cells revealed the virulence-associated protein E gene as a potential virulence factor in methicillin-resistant Staphylococcus aureus by Dengyuan Li, Yu Shi, Ning Zou, Tingting Yang, Wenpeng Gu, Feng Liao

“…The aim of this study was to explore the structure and function of the virE gene of MRSA, and to provide a basis for subsequent in-depth study of this gene. …”
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The Experience of Using a Combination of Febuxostat and Canakinumab in Tophaceous Gout Complicated by Chronic Kidney Disease in a Teenage Patient: A Case Study by Maria I. Kaleda, Irina P. Nikishina, Nurali Z. Zokirov, Alina V. Charlamova, Maxim S. Eliseev

“…Late initiation of treatment for tophaceous gout in the teenage patient caused chronic kidney disease. The successful experience of using a combination of canakinumab and febuxostat in a patient under 18 years old has been described for the first time.…”
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Predicting the course of localized periodontitis of traumatic etiology after complex treatment by Aleksandra V. Smirnova, Diana A. Kuzmina, Natalia A. Sokolovich, Ekaterina S. Mikhailova, Svetlana V. Sverdlova, Ivan V. Grigoriev

“…Conventional approaches to treatment are not always successful and do not necessarily provide a lasting effect. …”
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Effectiveness of Standalone Weight-bearing Radiographs in Guiding the Management of Supination External Rotation Type Isolated Lateral Malleolar Fractures in Indian Population: A P... by Singaravadivelu Vaidyanathan, Vignesh Murali, Aju Bosco

“…Periodic follow-up was done to assess radiological union and functional outcomes using the American Orthopaedic Foot and Ankle Society (AOFAS) score. …”
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Mechanism Analysis of Highly Effective Imidazole-Schiff Corrosion Inhibitor on P110 in HCl Solution by LIU Wenchao, WANG Pengjie, TANG Zijie, LI Hao, WANG Ming'an, LIU Wanying, LIN Yuanhua

“…In order to inhibit the corrosion of pipeline steel during oilfield acidification，an imidazole-Schiff corrosion inhibitor (IAP) was synthesized.The corrosion inhibition performance and mechanism of IAP corrosion inhibitor with different concentration on P110 steel in 15%HCl solution were studied through weight loss and electrochemical tests.Subsequently，Fourier infrared spectroscopy (FTIR)，scanning electron microscopy (SEM) ＋energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) were used to further confirm the inhibition mechanism of IAP on P110 steel in 15%HCl.In addition， the rationality of inhibition mechanism was further clarified from the molecular level by theoretical calculation.Results showed that when IAP added concentration was 400.0 mg/L，the weight loss test corrosion inhibition efficiency of P110 steel in 15%HCl was 97.58%， the test results of AC impedance spectrum (EIS) and potentiodynamic polarization (Tafel)curve showed that the corrosion inhibition efficiencies were 97.32%and 96.76%， respectively.EIS test results proved that IAP played a role in corrosion inhibition by forming film on the surface of P110 steel， and Tafel curve test results proved that IAP was a mixed corrosion inhibitor mainly based on anode inhibition.Meanwhile， the adsorption of IAP on P110 steel followed Langmuir isothermal adsorption equation and could be spontaneously adsorbed on the surface of P110 steel.FTIR，SEM＋EDS，and XPS successfully detected the protective film formed by IAP on the surface of P110 steel.Density functional theory (DFT) and molecular dynamics (MD) proved that the active sites of IAP were benzene ring and imidazole ring.Specifically，the benzene ring could accept excess electrons on the surface of Fe，the lone electron pair of N on the imidazole ring formed a stable coordination bond with Fe， and MD could further proved that IAP were spontaneously adsorbed on the surface of Fe.Overall，IAP corrosion inhibitor could demonstrate excellent corrosion inhibition performance in 15%HCl corrosive medium，with its mechanism involving the formation of a stable protective film on the surface of P110 steel.…”
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Filling knowledge gaps: A methodological approach for the rapid investigation of species with restricted populations by André Cesar Furlaneto Sampaio, Pablo Melo Hoffmann, Elivelton Marcos Gurski, Ollyver Rech Bizarro, Santiago José Elías Velazco, Marcos Bergmann Carlucci, Marília Borgo, Mayara Monteiro Ferreira, Alessandro Camargo Angelo, Christopher Thomas Blum

“…NDVI successfully detected habitat changes over time, revealing an 86.7% reduction in the focal habitat patch from 2013 to 2021, underscoring the species’ critical threat due to habitat degradation. …”
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Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation by Manzhen Liao, Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Wei Peng, Ting Huang, Huaiyang Chen, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin Xiao

“…Pulmonary artery sympathetic nerves were evaluated by pathological staining.ResultsThe SBRT procedure was successfully performed in all six rabbits. Compared to the control group, SBRT-PADN reduced pulmonary artery systolic pressure and mean pulmonary artery pressure in ATEPAH rabbits. …”
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Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach by Wen-Di Wang, Xin-Yi Fan, Xiao-Qi Wei, Wang-Jing Chai, Fang-He Li, Kuo Gao, Bin Liu, Bin Liu, Shu-Zhen Guo

“…In vivo, Z-LIG/CGA significantly improved cardiac function and reduced the fibrotic area in mice post-MI, surpassing the results in groups treated with Z-LIG or CGA alone. …”
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One-Year Monitoring of the Evolution of SARS-CoV-2 Omicron Subvariants Through Wastewater Analysis (Central Italy, August 2023–July 2024) by Alessandra Nappo, Maya Petricciuolo, Giulia Berno, Agnese Carnevali, Cesare Ernesto Maria Gruber, Giulia Bicchieraro, Roberta Spaccapelo, Martina Rueca, Fabrizio Carletti, Pietro Giorgio Spezia, Carolina Veneri, Giuseppina La Rosa, Elisabetta Suffredini, Daniele Focosi, Giovanni Chillemi, Ermanno Federici, Fabrizio Maggi

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Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for... by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…The primary outcome is the lowest SpO2 value from laryngoscopy to 2 minutes after successful ETI. Secondary outcomes include cognitive function on day 28. …”
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Automatic Segmentation of the Infraorbital Canal in CBCT Images: Anatomical Structure Recognition Using Artificial Intelligence by Ismail Gumussoy, Emre Haylaz, Suayip Burak Duman, Fahrettin Kalabalık, Muhammet Can Eren, Seyda Say, Ozer Celik, Ibrahim Sevki Bayrakdar

“…<b>Conclusions:</b> Accurate identification and preservation of the IOC during surgical procedures are of critical importance to maintaining a patient’s functional and sensory integrity. The findings of this study demonstrated that the IOC can be detected with high precision and accuracy using an AI-based automatic segmentation method in CBCT images. …”
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