Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation te... by Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Shinya Otsuki, Hironori Shimizu, Kazuyuki Nagai, Takumi Nomura, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki

“…We present a clinical case where [18F] FB (ePEG12)12-exendin-4 positron emission tomography/CT (18F-exendin-4 PET/CT) successfully detected insulinoma, unachievable by conventional imaging, underscoring its potential in guiding minimally invasive surgery.Case descriptionA 67-year-old female developed hyperinsulinemic hypoglycemia but could not undergo surgery as conventional imaging methods failed to localize the insulinoma. …”
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Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. by Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S C Butler, Gustav Rydström, Nina A Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg

“…Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. …”
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Identifying Prolonged Zero Value Periods as Part of Quality Control on Daily Rainfall Records in East Java, Indonesia by Dinda Rosyia Wibawanty, I Putu Santikayasa, Supari

“…Regarding prolonged dry spells, we successfully assessed 98% of extended dry spell events in East Java. …”
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Phylogenetic analysis of viruses in Tuscan Vitis vinifera sylvestris (Gmeli) Hegi. by Erika Sabella, Roberto Pierro, Andrea Luvisi, Alessandra Panattoni, Claudio D'Onofrio, Giancarlo Scalabrelli, Eliana Nutricati, Alessio Aprile, Luigi De Bellis, Alberto Materazzi

“…Our analysis of the whole amino acid sequences revealed a high conservation level for the studied proteins explained by a selective pressure on this genomic region, probably due to functional constraints imposed on CP, such as specific interactions with cellular receptors in the insect vectors necessary for successful transmission. …”
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Multi-heat keypoint incorporation in deep learning model to tropical cyclone centering and intensity classifying from geostationary satellite images by Thanh-Ha Do, Son-The Phan, Duc-Tien Du, Dinh-Quan Dang, Khanh-Hung Mai, Lars R. Hole

“…Experimental results, done on a constructed dataset for the Western North Pacific for 2015-2023 collected from the Japanese Himawari 8/9 geostationary satellite and the best track of the World Meteorological Organization (WMO) Regional Specialized Meteorological Center (RSMC) Tokyo - Typhoon Center, indicate that the proposed model successfully detects most TC existences on combined images from three infrared channels. …”
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A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes. by Sirintra Nakjang, Didier A Ndeh, Anil Wipat, David N Bolam, Robert P Hirt

“…These peptidases likely play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. …”
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Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment by Ziqin Wei, Ziqin Wei, Hongfang Mu, Fangfang Qiu, Fangfang Qiu, Minghui Zhao, Minghui Zhao, Xiaojing Zhang, Wenbin Li, Hai Jia, Rong Wang, Rong Wang

“…Rhodamine 123 accumulation assay was performed to examine the effect of HDAC inhibitors on ABCB1 functional activity. HDAC5 was targeted by siRNA technology to detect ABCB1 and H3K9ac expression. …”
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Rainbow Vectors for Broad-Range Bacterial Fluorescence Labeling. by Mariette Barbier, F Heath Damron

“…Only E2-Crimson, mCherry and mKeima were successfully detected for in vivo applications. Overall, E2-Crimson was the fastest maturing protein tested in E. coli with the best overall performance in the study parameters. …”
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Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro. by Daniel Koch, Ay Lin Kho, Atsushi Fukuzawa, Alexander Alexandrovich, Kutti J Vanaanen, Andrew Beavil, Mark Pfuhl, Martin Rees, Mathias Gautel

“…To study substrate specificity, mechanism and regulation of obscurin GEF function by individual domains, we successfully optimized recombinant production of obscurin GEF domains and found that MST-family kinases phosphorylate the obscurin DH domain at Thr5798. …”
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A systematic review of mapping strategies for the sonification of physical quantities. by Gaël Dubus, Roberto Bresin

“…Results confirm two hypotheses formulated in a preliminary study: pitch is by far the most used auditory dimension in sonification applications, and spatial auditory dimensions are almost exclusively used to sonify kinematic quantities. To detect successful as well as unsuccessful sonification strategies, assessment of mapping efficiency conducted in the reviewed works was considered. …”
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The changes of microbial diversity and flavor compounds during the fermentation of millet Huangjiu, a traditional Chinese beverage. by Yi Yan, Haiyan Chen, Leping Sun, Wei Zhang, Xin Lu, Zhenpeng Li, Jialiang Xu, Qing Ren

“…Our research provides essential information on microbial community succession and the flavor formation during millet Huangjiu fermentation, and beneficial for development of Huangjiu products.…”
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A high-frequency dataset of sea level observations from low-cost pressure sensors by Lucia Pineau-Guillou, Pascal Lazure

“…All the 30 sensors were successfully recovered. Among them, 22 sensors functioned properly recording full data, 5 sensors partially recorded data due to battery failure or malfunctioning, and only 3 sensors did not work, due to small holes in their plastic protection. …”
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Molecular Interactions Between Plants and Aphids: Recent Advances and Future Perspectives by Sunil Kumaraswamy, Yinghua Huang

“…These responses are diverse and highly dynamic, functioning either independently or in combination. …”
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Distinct neural representations of different linguistic components following sign language learning by Yael Coldham, Neta Haluts, Eden Elbaz, Tamar Ben-David, Nell Racabi, Shachar Gal, Michal Bernstein-Eliav, Naama Friedmann, Ido Tavor

“…Here we aim to explore the functional alterations following learning Israeli Sign Language, a visuo-spatial rather than an auditory-based language. …”
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The Dynamical Asymmetry in SARS-CoV2 Protease Reveals the Exchange Between Catalytic Activity and Stability in Homodimers by Velia Minicozzi, Alessandro Giuliani, Giampiero Mei, Leonardo Domenichelli, Mauro Parise, Almerinda Di Venere, Luisa Di Paola

“…The molecular approach to understanding the mechanisms of emerging diseases, like COVID-19, has largely accelerated the search for successful therapeutical strategies. In this work, we present an extensive molecular dynamics (MD) analysis of two forms of the SARS-CoV-2 main protease M^Pro. …”
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Experience of Parenteral Administration of Methotrexate in a Female Patient Suffering from Early Juvenile Idiopathic Arthritis and Uveitis by Т. V. Sleptsova, Е. I. Alexeeva, Т. М. Bzarova, S. I. Valieva, R. V. Denisova, K. B. Isaeva, Е. G. Chistyakova, А. М. Chomakhidze, N. I. Taybulatov

“…At the initial stage of treatment, the child demonstrated severe articular syndrome, inflammatory reactions affecting eyeball surfaces, increased laboratory indicators of the illness and functional insufficiency. Successful overcoming of methotrexate resistance through dosage increased up to 20 mg/m2 of body surface per week was described. …”
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Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors by I. V. Maev, D. S. Bordin, E. V. Barkalova, M. A. Ovsepyan, E. R. Valitova, N. G. Kalashnikova, D. N. Andreev

“…Evaluation of the results of high-resolution esophageal manometry showed that violations of the structure and function of the esophago-gastric junction were detected in 21 patients out of 52. …”
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Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar by Shangong Tong, Wenlong Li, Yuandong Rao, Yanqin Xiao, Yingyin Yan, Weiling Guo, Xucong Lü, Jinyuan Sun, Lianzhong Ai, Li Ni

“…This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar, and explore the core functional microbes closely related to the formation of flavor components. …”
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Phage therapy in antibiotic resistant pneumonia: immunomodulation or redistribution? by S. S. Bochkareva, I. M. Fedorova, O. N. Ershova, S. I. Koteleva, I. V. Kapustin, M. S. Blyakher, L. I. Novikova, A. V. Aleshkin, А. М. Vorobev

“…Statistical processing of the results was carried out using the Statistica 6 program according to the nonparametric Mann-Whitney U-test. In the course of successful phage therapy with individually selected bacteriophages overcoming of lymphopenia (if there was one) and an increase in both the number and functional activity of peripheral blood lymphocytes in all patients with pneumonia observed are noted. …”
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Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model by Daumante Suminaite, Nurul Fatihah Talib, Sophie Jane Pettegree, Han Chew Gaelan Tan, Yvonne Louise Odey, Emma Margaret Perkins, Alastair Robert Lyndon, Paul Andrew Skehel, Mandy Jackson

“…Here the CatWalk XT system was successful in detecting differences in both truncal stability and interlimb coordination across the disease course of β-III−/− mice. …”
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