Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging. by J Michael Mathis, Shilpa Bhatia, Alok Khandelwal, Imre Kovesdi, Stephen J Lokitz, Yoshi Odaka, Amol M Takalkar, Tracee Terry, David T Curiel

“…As the limits of existing treatments for cancer are recognized, clearly novel therapies must be considered for successful treatment; cancer therapy using adenovirus vectors is a promising strategy. …”
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TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell by Guoqiong Lei, Sushun Liu, Xin Yang, Chao He

“…The oxaliplatin-resistant model of P53 mutant colon cancer cell HT29 was successfully constructed. TRIM29 physically bound with mutant P53 and retained it in the cytoplasm from the nucleus, which inhibited its transcription function of downstream genes such as MDR1. …”
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Accumulation of long-chain unsaturated fatty acids in the airway inflammatory microenvironment drives eosinophil etosis and corticosteroid resistance by Yurong Bai, Pengda Fang, Shasha Li, Zhenhao Xiao, Wenyi Chen, Wenlong Li, Xinyue Wang, Jingyuan Chen, Yue Li, Junhai Chen, Weiqiang Huang, Xin Luo, Shigeharu Ueki, Deyu Fang, Qintai Yang, Yana Zhang

“…Functional analyses were performed on purified eosinophils. …”
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TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
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Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling by Xuechen Yin, Wenwen Chen, Xudong Ao, Luxia Xu, Jiujiu Cao, Tinghui Huang, Junqing Liang, Jianhua Hu, Jiaqi Liu, Xinping Wang, Wenying Li, Muya Zhou, Lingfeng He, Zhigang Guo

“…To further validate our observation, we also treated anti-mesothelin (MSLN) CAR-T cells with sodium citrate and detected the phenotypes and anti-tumor function of CAR-T cells.ResultsWe found that sodium citrate-pretreated anti-CD70 CAR-T cells exhibited reduced exhaustion, increased memory T cell proportions, and enhanced anti-tumor efficacy both in vitro and in vivo. …”
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Indocyanine green fluorescence to ensure perfusion in middle segment-preserving pancreatectomy: a case report by Tomohiro Iguchi, Norifumi Iseda, Kosuke Hirose, Mizuki Ninomiya, Takuya Honboh, Takashi Maeda, Fumi Sawada, Yu-ichi Tachibana, Tetsuro Akashi, Naotaka Sekiguchi, Noriaki Sadanaga, Hiroshi Matsuura

“…Insulin administration was necessary, but C-peptide was detectable and blood glucose was relatively well-controlled. …”
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An Affordable AI-Driven and 3D-Printed Personalized Myoelectric Prosthesis: Design, Development, and Assessment by Enzo Romero, Jose G. Garcia, Magno Parra, Sebastian Caballa, Alejandro M. Saldarriaga, Edson F. Luque, Dante J. Rodriguez, Victoria E. Abarca, Dante A. Elias

“…Conventional myoelectric prostheses, while offering functional restoration, have limited adaptability and high cost. …”
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Relevance of TNF-α, IL-6 and IRAK1 gene expression for assessing disease severity and therapy effects in tuberculosis patients by Ivana Buha, Vesna Škodrić-Trifunović, Tatjana Adžić-Vukičević, Aleksandra Ilić, Ana Blanka-Protić, Mihailo Stjepanovic, Marina Anđelković, Miša Vreća, Jelena Milin-Lazović, Vesna Spasovski, Sonja Pavlović

“… Introduction: Tuberculosis (TBC) is a contagious chronic respiratory disease which despite the known cause, Mycobacterium tuberculosis (Mtb), and many decades of successful therapy, remains one of the leading global health problems. …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…Fatty acids, among other substrates, are utilized by immune cells as an energy source. Therefore, L-carnitine, which is authorized as a feed additive in cattle, may influence the metabolism of peripheral blood mononuclear cells (PBMC) during an immune challenge. …”
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DNA extraction protocols for animal fecal material on blood spot cards. by Ann-Katrin Llarena, Thomas H A Haverkamp, Wenche Støldal Gulliksen, Kristin Herstad, Arne Holst-Jensen, Eystein Skjerve, Lisbeth Rannem, Sabrina Rodriguez-Campos, Øivind Øines

“…Further, the suitability of Illumina shotgun metagenomic sequencing at 20 million paired-end (PE) read depth per sample was assessed on its ability to successfully characterize the taxonomic and functional aspects of the resulting fecal microbiome.…”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

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Research on the construction of corneal endothelium transplantation with acellular amniotic membrane as a scaffold by Ya-Nan Chen, Rui-Qin Guo, Bo-Yu Liang, Hong-Qin Ke, Meng-Jie Dong, Ming-Fang He, Ji Yang, Hai Liu

“…Additionally, the expression of key genes critical for endothelial function was assessed to validate the functionality of the HAAM-based corneal endothelial transplantation membrane.ResultsThe HAAM was successfully prepared, maintaining an intact collagen fiber structure. …”
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Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains by Matthew H. Foley, Arthur S. McMillan, Sarah O'Flaherty, Rajani Thanissery, Molly E. Vanhoy, Mary Gracen Fuller, Rodolphe Barrangou, Casey M. Theriot

“…Despite their purported ability to inhibit pathogens and modulate the gut microbiota, probiotics have been used to treat C. difficile infections with little success. In this study, we examine how common probiotics can impact the recovery of the gut microbiota after antibiotics by measuring colonization resistance against C. difficile in a mouse model. …”
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Probing the Impact of Ionic Liquid Additives at the Buried NiOx/Perovskite Interfaces to Understand Solar Cell Performance by Juan Tirado, Mriganka Singh, Michel De Keersmaecker, Erin L. Ratcliff

“…Interface engineering strategies ultimately require the successful detection of near‐band energetics as well as the assessment of charge transport processes, including injection and/or extraction barriers under relevant electric fields. …”
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Evaluation of innovative technology market potential on the basis of technology audit by Oleksandra Kosenko, Victoriia Cherepanova, Iryna Dolyna, Viktoriia Matrosova, Olena Kolotiuk

“…This mechanism is built on structure evaluation table of technology market potential level detection as an object of commercialization. To ensure the efficiency of practical effect of the mechanism proposed, the authors systematized and completed methods of functional analysis and scanning of market environment for the purpose of qualitative comprehensive evaluation and innovative technology market potential forecasting.Introduction of the proposed evaluation method for technology market potential will result in the improvement of efficiency of enterprise innovation activity due to more rational distribution of available resources and immediate financing of developments with greater market potential.…”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiols in vivo and in vitro by Taotao Zhao, Tong Zhang, Zijun Tao, Zhe Zhou, Xiaofeng Xia, Zhengjun Wu, Feiyi Wang, Jun Ren, Erfei Wang

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One-Step Hydrothermal Synthesis of Multicolour Graphene Quantum Dots and Study of Their Luminescence Mechanism by Beibei Wang, Ling Sun, Kai Liu, Di Wu, Jinqiu Wang, Fang Geng

“…Multicolour graphene quantum dots (GQDs), from blue to orange emitting, were successfully synthesized via a one-step hydrothermal method using potassium hydrogen phthalate and o-phenylenediamine as the raw materials. …”
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Passive Microwave Component Design Using Inverse Scattering: Theory and Applications by Israel Arnedo, Iván Arregui, Magdalena Chudzik, Fernando Teberio, Aintzane Lujambio, David Benito, Txema Lopetegi, Miguel A. G. Laso

“…We provide the theoretical foundations based on inverse scattering and coupled-mode theory as well as several applications where the devices designed following those techniques have been successfully tested. The main characteristics of these synthesis methods are as follows. …”
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Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection by Zonglei Zhou, Jie Tian, Yuying He, Haiyan Xiong, Weibing Wang

“…ABSTRACT Tuberculosis (TB) stages depend greatly on the interaction between Mycobacterium tuberculosis (Mtb) and the host response. As a non-negligible source of active tuberculosis (ATB), individuals with latent Mtb infection (LTBI) are insidious and hard to be detected due to limited biomarkers. …”
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