Accumulation of long-chain unsaturated fatty acids in the airway inflammatory microenvironment drives eosinophil etosis and corticosteroid resistance by Yurong Bai, Pengda Fang, Shasha Li, Zhenhao Xiao, Wenyi Chen, Wenlong Li, Xinyue Wang, Jingyuan Chen, Yue Li, Junhai Chen, Weiqiang Huang, Xin Luo, Shigeharu Ueki, Deyu Fang, Qintai Yang, Yana Zhang

“…Functional analyses were performed on purified eosinophils. …”
Get full text

Multiwavelength Variability Analysis of the Blazar PKS 0727-11: An ~ 168 day Quasiperiodic Oscillation in the γ-Ray by Yuncai Shen, Tingfeng Yi, Vinit Dhiman, Lisheng Mao, Liang Dong

“…It is the first time that periodic variations have been detected in this source, and further supported by other methods: weighted wavelet z -transform, phase dispersion minimization, REDFIT, autoregressive integrated moving average model, and structure function analysis. …”
Get full text

Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes by Ivan Borrello, Amy Thomas, Luca Biavati, Robert Leone, Elizabeth M Zawidzka, Claudio Zanettini, Luigi Marchionni

“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
Get full text

Editorial by Teddy Surya Gunawan

“…Notably, identifying Rhizopus sp. fungi as an alternative lactic acid source and the ozonation of vegetable oils underscore efforts toward environmentally friendly biochemical processes. …”
Get full text

Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…The application compares and detects changes in fish individuals at each location. …”
Get full text

Multi-omics analyses reveal fecal microbial community and metabolic alterations in finishing cattle fed probiotics-fermented distiller’s grains diets by Rong Zhang, Shihui Mei, Guangxia He, Miaozhan Wei, Lan Chen, Ze Chen, Min Zhu, Bijun Zhou, Kaigong Wang, Zhentao Cheng, Chunmei Wang, Erpeng Zhu, Chao Chen

“…ABSTRACT Distiller’s grains (DG) are a potential source of animal feeds, and many studies have indicated positive regulatory roles of feeding DG diets in animal breeding. …”
Get full text

The Effect of Different Levels of CLA and Omega-3 Supplements Along with Essential Oils of Fennel, Peppermint, and Eucalyptus Medicinal Plants on Production Performance, Blood Para... by Yadollah Chashnidel, Matin Movagharnezhad, Mehdi Jafary charati

“…It is better to use sources containing antioxidant compounds along with sources containing fatty acids to reduce the occurrence of these risks. …”
Get full text

Antibiotic Resistance and Virulence Determinants of <i>Pseudomonas aeruginosa</i> Isolates Cultured from Hydrocarbon-Contaminated Environmental Samples by Chioma Lilian Ozoaduche, Balázs Libisch, Daniel Itoro, Iyore Blessing Idemudia, Katalin Posta, Ferenc Olasz

“…In some of these <i>P. aeruginosa</i> strains, loss-of-function mutations were detected in the regulatory genes <i>mexR</i>, <i>nalC</i>, or <i>nalD</i>, predicting an efflux-mediated acquired antibiotic-resistance mechanism. …”
Get full text

Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults by Julianna M. Nemeth, Clarice Decker, Rachel Ramirez, Luke Montgomery, Alice Hinton, Sharefa Duhaney, Raya Smith, Allison Glasser, Abigail (Abby) Bowman, Emily Kulow, Amy Wermert

“…Our aims were to 1. characterize the lifetime co-occurrence of strangulation and intentional head trauma exposures from all abuse sources to the same survivor and within select physical episodes of IPV and 2. establish the lifetime prevalence of PIBI. (2) Methods: Survivors seeking DV services in the state of Ohio in the United States of America (U.S.) completed interview-administered surveys in 2019 (<i>n</i> = 47). …”
Get full text

Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…At least two independent reviewers will conduct the study selection and data extraction using prespecified forms and assess the risk of bias with the SYRCLE’s tool. …”
Get full text

Memory Mining and Spatial Transformation of Daily Landscape in Renewal of Tianjin Old City by Chunyan ZHANG, Xinyi ZHANG, Tianying HOU

“…Three novels by renowned Tianjin author Feng Jicai — Yin-Yang Eight Trigams, Three-Inch Golden Lotus, and Faces in the Crowd — are selected as primary data sources. Through text mining and semantic sentiment analysis, these works reveal three distinct emotional characteristics of daily landscapes. 1) Bustling Scenes: Positive emotional spaces, such as religious sites and venues associated with traditional artisans and eccentric figures, reflect the region’s commitment to preserving traditions and fostering a sense of collective enjoyment. …”
Get full text

Interrelation of indicators of oxygen metabolism of neutrophils and antiendotoxin immune as a marker of the postoperative period in patients with acute colonic obstruction by A. V. Pikuza, A. M. Zakirov

“…Special research methods included the assessment of the state of the microbicidal function of neutrophilic granulocytes using reactive spontaneous (SSLCL) and zymosan-induced luminol-dependent chemiluminescence tests (ILZHL). …”
Get full text

Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves&rsquo; Disease and Graves&rsquo; Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…Then, downstream analyses were performed to detect protein interactions, gene function, cell type-specific expression and druggable information.Results: This study genetically predicted levels of 62 plasma proteins were associated with GD risk. …”
Get full text

Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis by Reza Hashemi, Mohammad M. Hussein M. Raouf, Tanya S. Salih, Marzieh Feyzpour, Maryam Eskandarioun, Najmeh Nezamabadipour, Hossein Gandomkar

“…Abstract Background Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in neuroplasticity and cognitive function, with its dysregulation linked to neurodegenerative and psychiatric disorders. …”
Get full text

Isolation and Characterization of L-Asparaginase-Producing Bacteria from the Arabian–Persian Gulf Region: First Report on <i>Bacillus xiamenensis</i> ASP-J1-4 as a Producer and Its... by Ghofran M. Al-Harbi, Essam Kotb, Abeer A. Almiman, Mahmoud M. Berekaa, Salwa Alhamad, Nada F. Alahmady, Meneerah A. Aljafary, Nadiyah M. Alqazlan, Reem I. Alyami, Joud M. Alqarni, Ebtesam Abdullah Al-Suhaimi

“…L-asparaginase (L-ASNase) functions as a chemotherapeutic enzyme with antitumor properties. …”
Get full text

High-resolution spatiotemporal measurement of air and environmental noise pollution in Sub-Saharan African cities: Pathways to Equitable Health Cities Study protocol for Accra, Gha... by Michael Brauer, Majid Ezzati, Sierra N Clark, Abosede S Alli, Jill Baumgartner, Mireille B Toledano, Allison F Hughes, James Nimo, Josephine Bedford Moses, Solomon Terkpertey, Jose Vallarino, Samuel Agyei-Mensah, Ernest Agyemang, Ricky Nathvani, Emily Muller, James Bennett, Jiayuan Wang, Andrew Beddows, Frank Kelly, Benjamin Barratt, Sean Beevers, Raphael E Arku

“…Our design uses a combination of fixed (year-long, n=10) and rotating (week-long, n =~130) sites, selected to represent a range of land uses and source influences (eg, background, road traffic, commercial, industrial and residential areas, and various neighbourhood socioeconomic classes). …”
Get full text

Multimessenger Signatures of a Deformed Magnetar in Gamma-Ray Bursts by Parisa Hashemi, Soroush Shakeri, Yu Wang, Liang Li, Rahim Moradi

“…It is shown that the GW and EM emissions evolve as a function of eccentricity and rotational frequency with time. …”
Get full text

In situ, modeled, and earth observation monitoring of surface water availability in West African rangelands by Kimberly Slinski, Kimberly Slinski, Gabriel B. Senay, Alkhalil Adoum, Shraddhanand Shukla, Amy McNally, James Rowland, Erwann Fillol, Soni Yatheendradas, Soni Yatheendradas, Chris Funk, Andrew Hoell, Michael Jasinski

“…The 12 locations can function as sentinel ponds to monitor local water availability. …”
Get full text

Identification of miRnas with possible prognostic roles for HAM/TSP by Daniela Raguer Valadão de Souza, Rodrigo Pessôa, Youko Nukui, Juliana Pereira, Rosa Nascimento Marcusso, Augusto César Penalva de Oliveira, Jorge Casseb, Alberto José da Silva Duarte, Patricia Bianca Clissa, Sabri Saeed Sanabani

“…The seven most deregulated miRs target genes have been associated with a variety of biological processes and molecular functions. The reactome pathways relevant to our findings provide a rich source of data and offer the opportunity to better understand sRNA regulation and function in HTLV-1 pathophysiology. …”
Get full text

Analysis of the Stability of the Banking Sector of Azerbaijan in Conditions of Economic Crisis Based on the Econometric Model by S. M. Huseynova, T. Ja. Hajizada

“…Information was taken from a number of sources: 1) Official website of the Central Bank of Azerbaijan; 2) Official website of Ministry of Finance; 3) Official website of Azerbaijan State Statistics Committee; 4) Reports on the development of the banking sector and banking supervision. …”
Get full text