PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

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Efficacy of angiotensin receptor blockers for erectile dysfunction in hypertensive men: A systematic review by Swati Sucharita Dash, Harshita K Kothari, Shashwati Pankaj, Lakshmi Venkatachalam, Jignesh Bhate, Guruprasad K S Rao

“…A literature search was carried out in Medline, Embase, the Cochrane Library databases, and other relevant sources to select clinical studies that compared the efficacy of ARBs with other antihypertensive drugs in men with concomitant hypertension and ED. …”
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Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…A complementary approach using digital biomarkers to surpass exam-based limitations for detecting physical change coupled with a direct report from participants on what their sources of suffering are could be a useful advance in reporting beneficial effects of interventions, particularly if changes track together. …”
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Exploration of the interaction between antimicrobial peptides and gamma radiation for biosensor development. by Fabiane Modenese Garbim, Marcela Rabelo De Lima, Giulianna Santos Pereira, João Nilton Conceição Bandeira, Álvaro José Mendes-Boareto, Fernando Manuel Araújo-Moreira, N.F.G. Serrano

“…These findings indicate that, although AMPs demonstrate changes in activity as a function of dose and could be explored for biosensing, their functional stability is limited at higher radiation doses. …”
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Milk phenomics: leveraging biological bonds with blood and infrared technologies for evaluating animal nutritional and health status by Diana Giannuzzi, Chiara Evangelista, Angela Costa, Giuseppe Conte, Gianluca Neglia, Umberto Bernabucci, Stefano Schiavon, Marcello Mele, Alessio Cecchinato

“…Indeed, monitoring the nutritional and health status becomes paramount, aiming for an early detection of (sub)clinical health impairments. Given the mammary gland’s centrality in high-yielding dairy breeds, it’s unsurprising that the milk matrix provides insights about udder itself but also systemic metabolic function. …”
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Optimizing extraction of microbial DNA from urine: Advancing urinary microbiome research in bladder cancer by Chuang-Ming Zheng, Ho Won Kang, Seongmin Moon, Young Joon Byun, Won Tae Kim, Yung Hyun Choi, Sung-Kwon Moon, Xuan-Mei Piao, Seok Joong Yun

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Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…Introduction Non-pharmacological interventions, including musculoskeletal manipulations (MMs), have been proven effective for musculoskeletal disorders.Objectives To evaluate if MMs, including osteopathic manipulation and chiropractic care, are effective to improve quality of life, pain intensity and function in older adults with musculoskeletal disorders.Design Systematic review.Data sources A systematic search was conducted on MEDLINE/PubMed, EMBASE, Scopus, Web of Science, CINAHL, Cochrane Library, from database inception up to 2 January 2025.Eligibility criteria Randomised controlled trials, controlled non-randomised trials and open label trials evaluating the efficacy and safety of MM such as osteopathic manipulation, chiropractic manipulation, myofascial release, craniosacral therapy, as monotherapy or adjunctive therapies in older people (age ≥65 years) with musculoskeletal disorders. …”
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Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy by Afonso Mendes, Bruno M. Saraiva, Guillaume Jacquemet, João I. Mamede, Christophe Leterrier, Ricardo Henriques

“…Understanding these structures provides insights into their functional roles. While super-resolution microscopy can visualise such patterns, manual detection in large datasets is challenging and biased. …”
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GENERATION AND COLLECTION OF TOBACCO AEROSOL FOR SHISHA by N. N. Bubnova, M. V. Shkidyuk

“…Qualitative characteristics of tobacco aerosol for shisha are determined by the functional purpose and depend on the component composition of the tobacco mixture and the coal used.The purpose of the research is to develop a methodology for the comprehensive assessment of tobacco for shisha based on modern methods of product quality control and includes the following steps:- monitoring of the studies to determine the component composition of the hookah mixture and the aerosol produced;- analysis of hookah mixture testing modes and development of an aerosol generation protocol;- development of a method for collecting aerosol on a laboratory smoking machine; - quantitative analysis of toxic analytes by HPLC MS / MS method.Methods have been developed for the machine generation and collection of tobacco aerosol for hookah, taking into account low concentrations of the analyzed toxic substances.The expediency of using the HPLC MS / MS method to determine the quantity of the following substances in tobacco aerosol for shisha has been substantiated:- carbonyl compounds (formaldehyde, acetaldehyde, acrolein) by detection on an electrospray source in the negative polarity mode- tobacco specific nitrosoamines (NNN and NNK) by detection on an electrospray source in the positive polarity mode.During the research laboratory and analytical equipment was used: a five-channel linear CERULEAN SM 405 smoking machine; Thermo Scientific Dionex UltiMate 3000 liquid chromatograph and TSQ Quantiva mass spectrometer.Obtaining experimental data on the quantitative determination of the component composition of the aerosol produced by tobacco for shisha using hookah systems is relevant for assessing toxic characteristics of the product.…”
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Factors influencing brain recovery from stroke via possible epigenetic changes by Orjon Rroji, Carla Mucignat

“…Aim: To examine epigenetic changes leading to functional repair after damage to the central motor system.Data sources: A literature search was conducted using medical and health science electronic databases (PubMed, MEDLINE, Scopus) up to July 2023.Study selection: Data were summarized for type of intervention, study design, findings including human and animal studies.Data extraction: Data were extracted and double-checked independently for methodological quality. …”
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Investigation of some probiotic properties of Lactobacillaceae strains isolated from traditional Tulum cheese in Turkey by Eda Kiliç Kanak, Suzan Öztürk Yilmaz

“…Important information was obtained on the probiotic and functional properties of Lactobacillaceae strains isolated from traditionally fermented Tulum cheese, which can be used as a rich source of probiotic bacteria. …”
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Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing by Jiatong Li, Ningning Yu, Nina Sun, Lige Geng, Yanmin Qie, Dongfeng Zhai, Yuxiang Wang, Linzhi Li, Xueqing Liu, Xusheng Sun, Jiangchun Wang, Ruishan Liu, Guantong Pan, Shengmao Zou, Guohao Han, Yuli Jin, Pengtao Ma

“…Molecular markers JS717/JS718 and WGRC1096 were confirmed to be available for marker-assisted selection (MAS) of PmLxd-682 in breeding practices. …”
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Software para el control epidemiológico de la mortalidad por enfermedades crónicas no transmisibles y otros daños a la salud by Rolando Sánchez Montero, Enrique Félix Vázquez Ochoa

“…The software facilitated the making of charts of data using conditional function, which allowed calculating the mortality by the mentioned data, the calculation for every month and the pondered rates. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area by Wang YI, Longjun LIANG, Lichong YAN, Zhihua YAN, Jie CHEN, Wei GAO, Yi LOU, Fuqin YANG, Haiyang HU, Jiawei ZHU

“…It innovated and explored the following high efficiency extraction technology of “four zones” linked Wells in coal mining areas with Guizhou characteristics: ① By laying multi-functional pumping vertical Wells or small inclination oriented Wells in the goaf, it was the first time in Guizhou to realize efficient extraction and development of pressure relief gas in the overlying coal-covered strata and coal-bed methane in the sweet coal seam below the goaf; ② Taking advantage of the characteristics of spatial and temporal dislocation in the production area, the multi-mode extraction mode of “coalbed methane well + relief well + underground drilling” is adopted for the first coal seam mined in the upper protective layer, which realizes the purpose of the upper and lower vertical combined extraction of coalbed methane (gas) Wells and effectively solves the problem of multi-source gas flooding into coal mining roadway and gas accumulation in the upper corner during coal mining under the condition of coal seam group development in Guizhou; ③ In the preparation area and planning area, combined with the terrain and geological characteristics of the two areas, the horizontal well “well factory” + “two pairs of right and wrong” overlapping well layout mode is adopted to realize the efficient extraction of coal bed methane in the plane in advance and pre-pumping of the sweet coal seam and the pressure relief gas in the overlying coal-laden rock in the subsequent mining process, and at the same time to achieve the goal of “replacing the roadway with Wells”; ④ In view of the development of multi-thin coal seam groups in the study area and the development characteristics of “three zones” in the overlying strata after mining, due to the continuous change of the role of “four zones”, the surface coalbed methane Wells are initially deployed in the production area or preparation area, and the “bridge plug bottom sealing + layer selection perforation” technology is adopted to innovate the “transformation” technology of well structure to achieve the purpose of “multi-purpose in one well”; It also provides new technical ideas and accumulated valuable engineering experience for gas management in coal mine area under the condition of multi-thin coal seam group development in Guizhou.…”
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Development and Application of a Multi-scale Framework for Evaluating Floodplain Restoration Suitability Based on HEC-RAS by Shuoxing LI, Nanxi WANG, Yan ZHA

“…This research uses a multi-level hierarchical screening method to select indicators at three scales: basin, sub-basin and site. …”
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Extraction, Isolation, and TEMPO-NaBr-NaClO Oxidation Modification of Cellulose from Coffee Grounds by Mourad Ouhammou, Abdellah Mourak, Aziz Ait-Karra, Jaouad Abderrahim, Najat Elhadiri, Mostafa Mahrouz

“…These chemical modifications improve the cellulose’s reactivity, broadening its potential applications in various fields, including biocomposites, sustainable packaging materials, and functional films. This work demonstrates the feasibility of utilizing coffee ground residues as a renewable, eco-friendly source of modified cellulose for high-value applications.…”
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Thrombus rooting in the pulmonary arteriovenous fistula in a patient with cryptogenic stroke, a case report by Ming Song, Honggang Dai, Weida Lu, Xiao Meng

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Guarantees of family stability in the Holy Quran and the Prophet's Sunnah | ضمانات الاستقرار الأسري في القرآن الكريم والسنة النبوية (دراسة وصفية تحليلية)... by Aisha Shareef

“…I made him an introduction in which I talked about the importance of the topic and the reasons for its selection and previous studies and I divided it into three investigations and under each topic a number of demands. …”
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Extracting Realistic Pedestrian, Cycling, and Driving Street Networks from OpenStreetMap by J. P. Duque, M. A. Brovelli

“…While OSM is a valuable source of information, it is not exempt from inconsistencies and errors, particularly affecting pedestrian and cycling networks, which can lead to inaccurate navigation or unsafe routes. …”
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Phosphate transporter gene families in rye (Secale cereale L.) – genome-wide identification, characterization and sequence diversity assessment via DArTreseq by David Chan-Rodriguez, Brian Wakimwayi Koboyi, Sirine Werghi, Bradley J. Till, Julia Maksymiuk, Fatemeh Shoormij, Abuya Hilderlith, Anna Hawliczek, Maksymilian Królik, Hanna Bolibok-Brągoszewska

“…Each PHT family has a particular physiological and cellular function. Rye (Secale cereale L.) is a member of Triticeae, and an important source of variation for wheat breeding. …”
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