Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes by Ivan Borrello, Amy Thomas, Luca Biavati, Robert Leone, Elizabeth M Zawidzka, Claudio Zanettini, Luigi Marchionni

“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
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Current status of developments in the field of respiratory syncytial virus vaccines by Tatiana S. Kotomina

“…This was facilitated by research to identify the structure of RSV, to study the basic functions of RSV components as well as the mechanisms of innate and acquired immune responses to infection. …”
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Reinforcement Learning for Optimizing Renewable Energy Utilization in Buildings: A Review on Applications and Innovations by Panagiotis Michailidis, Iakovos Michailidis, Elias Kosmatopoulos

“…For evaluation, the paper examines and outlines the different attributes in the field considering the following: methodologies of RL; agent types; value-action networks; reward functions; baseline control approaches; RES types; BEMS types; and building typologies. …”
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Gene expansion in the hawkmoth Manduca sexta drives evolution of food-associated odorant receptors by Megha Treesa Tom, Philipp Brand, Sascha Bucks, Jin Zhang, Mario Ernesto Escobar Huezo, Bill S. Hansson, Sonja Bisch-Knaden

“…Our results suggest a link between the studied OR expansion and enhanced detection of odors emitted by valuable nectar sources in M. sexta.…”
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Real-time monitoring of tea volatiles using soft ionization by chemical reaction in transfer with an online sampling interface by Tiange Gu, Jingyi Sun, Saiting Wang, Xiaokun Duan, Hongli Li, Charles Liu, David Da Yong Chen

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Greenhouse gas emissions of global construction material production by Seth Kane, Josefine A Olsson, Sabbie A Miller

“…Both construction material production and emissions are primarily driven by structural materials, such as concrete and steel. Material selection can play a key role in reducing emissions in the context of the function, with variation in emissions of structural materials per unit strength between 0.001–0.1 kg CO _2 /kg/MPa and in insulation materials per R -value/thickness of 0.018–0.14 kg CO _2 /kg/(K⋅m ^2 W ^−1 ))). …”
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Combining dopamine and glucose sensings on paper devices for the metabolic study of neurosecretion by Rémi F. Dutheil, Dabeaurard Tho, Iman Pitroipa, Raphaël Trouillon

“…Glucose, the main source of energy of the human body, and dopamine, a major neurotransmitter, are two analytes widely investigated in the study of the brain. …”
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A novel approach to field data augmentation with remote sensing and machine learning in rangelands by Hailey E. Schmidt, Javier Osorio Leyton, Efrain Noa Yarasca, Sorin C. Popescu, Justinn J. Jones, Justin P. Wied, Xinyuan Wu

“…However, these ecosystems are increasingly threatened by woody plant encroachment (WPE), which impacts forage availability, habitat quality, and other ecosystem functions. Despite advances in remote sensing and machine learning (ML) for monitoring and managing WPE, a significant gap persists in providing effective, scalable, and high-quality training data to support early detection efforts. …”
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Prediction of the pharmaceutical solubility in water and organic solvents via different soft computing models by A. Yousefi, k. movagharnejad

“…Molecular weight, melting point, temperature and the number of each functional group in the pharmaceutical compound and organic solvents were selected as the input variables of these three different neural network models. …”
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Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…Introduction Non-pharmacological interventions, including musculoskeletal manipulations (MMs), have been proven effective for musculoskeletal disorders.Objectives To evaluate if MMs, including osteopathic manipulation and chiropractic care, are effective to improve quality of life, pain intensity and function in older adults with musculoskeletal disorders.Design Systematic review.Data sources A systematic search was conducted on MEDLINE/PubMed, EMBASE, Scopus, Web of Science, CINAHL, Cochrane Library, from database inception up to 2 January 2025.Eligibility criteria Randomised controlled trials, controlled non-randomised trials and open label trials evaluating the efficacy and safety of MM such as osteopathic manipulation, chiropractic manipulation, myofascial release, craniosacral therapy, as monotherapy or adjunctive therapies in older people (age ≥65 years) with musculoskeletal disorders. …”
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Tracing the Earliest Stages of Star and Cluster Formation in 19 Nearby Galaxies with PHANGS-JWST and HST: Compact 3.3 μm Polycyclic Aromatic Hydrocarbon Emitters and Their Relation... by M. Jimena Rodríguez, Janice C. Lee, Remy Indebetouw, B. C. Whitmore, Daniel Maschmann, Thomas G. Williams, Rupali Chandar, A. T. Barnes, Oleg Y. Gnedin, Karin M. Sandstrom, Erik Rosolowsky, Adam K. Leroy, David A. Thilker, Hwihyun Kim, Jiayi Sun, Ralf S. Klessen, Brent Groves, Aida Wofford, Médéric Boquien, Daniel A. Dale, Leonardo Úbeda, Kirsten L. Larson, Kathryn Grasha, Kelsey E. Johnson, Rebecca C. Levy, Frank Bigiel, Hamid Hassani, Sumit K. Sarbadhicary

“…We establish a selection criteria based on a median color threshold of F300M − F335M = 0.67 at F335M = 20 and identify 1816 sources. …”
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Fat globule size distribution in commercial ice cream determined through ideal application of the laser diffraction technique by Rafael A. Garcia, Faith Olszewski, Benjamin M. Plumier

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Effectiveness of exercise therapy in patients with knee osteoarthritis: an overview of systematic reviews by Daisuke Sasaki, Takashi Kitagawa, Yuichi Isaji, Kunihiro Onishi, Masateru Hayashi, Wataru Okuyama

“…Objective This study aimed to assess the methodological quality of published systematic reviews of exercise therapy in knee osteoarthritis and summarise their reported effectiveness on quality of life, knee joint function, or adverse events.Design Overview of systematic reviews.Data sources PubMed, Embase, CINAHL, Web of Science and CENTRAL (searched on 14 April 2025), plus grey literature (PROSPERO, Epistemonikos, OpenGrey).Eligibility criteria for selecting studies We included systematic reviews of randomised controlled trials in patients diagnosed with knee osteoarthritis by imaging or clinical criteria and treated conservatively with exercise therapy; we excluded reviews that enrolled patients scheduled for surgery, with acute inflammation or osteoarthritis of other joints (hand, hip, ankle), for which relevant author data could not be obtained after one contact attempt, or that did not report at least one primary outcome (quality of life, knee joint function or adverse events).Data extraction and synthesis Two reviewers independently extracted data on study characteristics, interventions and outcomes, and assessed methodological quality using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews 2) tool. …”
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Bridging Behavioural, Neural, and First-Person Insights into Working Memory Strategies by Anka Slana Ozimič, Nina Purg Suljič, Aleš Oblak, Jurij Bon, Toma Strle, Grega Repovš

“… Working memory is a core cognitive function, yet findings regarding its behavioural and neural underpinnings are often inconsistent. …”
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Theoretical Model of Possibility of 15-minute City in Urban Planning Using the Meta-Synthesis Method by Hafez Mahdnejad

“…About 81% of the sources are related to the years 2022 and 2021. 16% of the selected sources are related to the years 2020 and 2019. …”
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Why the term "professional language" can confuse the reader? by Les?aw Cirko

“…In the first part of the article, the aforementioned sources of interpretative dangers in reading are pointed out, using the history of research as an example. …”
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Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin by F. Mansouri

“…MBP-brazzein system permits large-scale functional expression and purification of recombinant soluble proteins, providing a basis for the future study of structure and function of brazzein.…”
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Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing by Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum

“…Secondly, the study demonstrates the use of Configurable Function Blocks (CFCs) in digital relays to dynamically adjust relay settings based on zero sequence current detection. …”
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An openEHR based infection control system to support monitoring of nosocomial bacterial clusters and contacts by Pascal Biermann, Claas Baier, Ann Christin Vietor, Benedikt Zacher, Tom Baumgartl, Tatiana von Landesberger, Michael Behnke, Michael Storck, Markus Petzold, Martin Kaase, HiGHmed lnfection Control Study Group, Dirk Schlüter, Michael Marschollek, Simone Scheithauer, Antje Wulff

“…Digital, routine data-driven solutions are promising, but often proprietary, non-interoperable, or limited in functional scope. The open-source Smart Infection Control System (SmICS) offers automatic calculations and interactive views on patients' movement and lab data, epidemic curves, contact networks, complemented by temporal-spatial visualizations. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…Elevation, precipitation, village density, and PA size did not substantially influence occupancy. Black bear detection probability became 100 % only above 14 km survey effort, indicating its overall rarity, and bears were much more easily detected during and after rainfall. …”
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