Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

“…The Kv3.2 subfamily of voltage activated potassium channels encoded by the KCNC2 gene is abundantly expressed in neurons that fire trains of fast action potentials that are a major source of cortical inhibition. Gain-of-function (GOF) de novo pathogenic variants in KCNC1 and KCNC2, encoding Kv3.1 and Kv3.2 respectively, cause several types of epilepsy including developmental and epileptic encephalopathy (DEE). …”
Get full text

Real-time monitoring of tea volatiles using soft ionization by chemical reaction in transfer with an online sampling interface by Tiange Gu, Jingyi Sun, Saiting Wang, Xiaokun Duan, Hongli Li, Charles Liu, David Da Yong Chen

Get full text

Spatiotemporal impact of mesoscale eddies on chlorophyll-a concentration in the North Atlantic by Jinghui Cai, Jialong Sun, Jialong Sun, Jialong Sun, Siyuan Qin, Yaonan Li

“…IntroductionMesoscale eddies play a crucial role in energy transport and ecological regulation in the North Atlantic Ocean.MethodsBased on multi-source datasets, including satellite remote sensing and Argo float observations from 2009 to 2018, this study employs the Velocity Gradient Detection (VGD) method to identify eddy boundaries and cores, in combination with a spatiotemporal dynamic matching technique, to systematically analyze eddy characteristics and their impacts on chlorophyll-a (Chl-a) concentrations.ResultsResults show that eddy activity is predominantly concentrated in the Gulf Stream extension region (24°N–48°N, 40°W–60°W). …”
Get full text

Modern Hardware and Software Solutions for Whole-Genome Sequencing, Prospects of Their Implementation in the Practice of Nuclear, Chemical and Biological Protection Troops of the A... by A. A. Petrov, A. V. Kazantsev, E. A. Kovalchuk, M. Yu. Pavlyukov, A. V. Sapkulov, D. A. Kutaev, S. V. Borisevich

“…One of the promising areas for improving laboratory diagnostics is the active introduction of next-generation sequencing (NGS), which retains the key advantages of molecular tests and allows the detection of a wide range of diverse microorganisms. …”
Get full text

Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…In the present study, we show that replacing ECB balance sheet size with random numbers leads to statistically indistinguishable shock response functions and time series of abnormal monetary policy shocks. …”
Get full text

Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review by Liu Y, Zhang M, Wang T, Zhang J

“…ARG1 rich M2 cells convert L-arginine into proline, fostering collagen deposition; Ym1/2, Fizz1 and CD206 correlate with airway remodeling and declining lung function. Emerging antioxidant and macrophage-polarization strategies that selectively modulate ROS show promise in rebalancing M1/M2 responses and attenuating airway hyper-responsiveness. …”
Get full text

Identification of Cancer Stem Cell (CSC)-Associated Genes, Prognostic Value, and Candidate Drugs as Modulators of CSC-Associated Signaling in Carcinomas Through a Multiomics Data A... by Pallabi Mondal, Poulami Singh, Krishna Mahanti, Sankar Bhattacharyya

“…This ability of CSCs to escape immune responses makes the CSCs a primary source of functionally altered, immune-resistant, chemoresistant, aggressive tumor cells. …”
Get full text

Reduction of Total Phenols in Virgin Olive Oil as a Preservation Medium during Cold Storage of Whey Cheese and Tofu by Valerija Majetić Germek, Ivana Gobin, Doris Franjković, Marija Marković, Olivera Koprivnjak

“…Virgin olive oil, known as a good source of health-promoting hydrophilic phenols, is traditionally used as a medium for preserving various foods. …”
Get full text

Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse... by Yao-Kun Zhang, Liang Zhang, Xue Ni, Shu-Wen Zhang, Min-Zhi Jiang, Si-Lu Zhang, Guo-Xun Xiao, He Jiang, Ming-Xia Bi, Yu-Lin Wang, Chang Liu, Shuang-Jiang Liu

“…In this study, we characterized 16 B animalis subsp. lactis isolates from fecal samples and probiotic sources. We assessed the genotype-phenotype correlations related to growth, carbon source utilization, and stress tolerance in vitro. …”
Get full text

Bacteriological Quality Assessment of Water Sold in Plastic Jerry cans within Katsina Metropolis, Katsina State, Nigeria. by Galadanchi Fatima A., Shamsuddeen Umar, Yusuf Buhari, Abubakar Abdulazeez, Salisu Mansur Dabai

“…It is the most abundant molecule in living cells, essential for the proper functioning of cells. It is one of the cheap vehicles that transport gastro-intestinal diseases. …”
Get full text

Gallium oxide (Ga2O3) as a radiation detector distinguishing neutrons and gammas by D. J. Valdes, L. Rendon, J. Winkelbauer, P. Koehler, S. C. Vogel, K.-X. Sun

“…Gallium oxide (Ga2O3) is a promising ultrawide bandgap semiconductor for radiation detection with the potential of integrating electronic and scintillation functions within a single crystal device. …”
Get full text

New Insights on Quality, Safety, Nutritional, and Nutraceutical Properties of Honeydew Honeys from Italy by Andrea Mara, Federica Mainente, Vasiliki Soursou, Yolanda Picó, Iratxe Perales, Asma Ghorab, Gavino Sanna, Isabel Borrás-Linares, Gianni Zoccatelli, Marco Ciulu

“…This contribution aims to provide a comprehensive characterization of the physico-chemical, palynological, functional, and food safety properties of a large sampling of honeydew honeys collected throughout Italy. …”
Get full text

Artificial intelligence analysis in cyber domain: A review by Liguo Zhao, Derong Zhu, Wasswa Shafik, S Mojtaba Matinkhah, Zubair Ahmad, Lule Sharif, Alisa Craig

“…The results in this study demonstrated that using a proportional collection of instances trained with the deep learning algorithm, a classified data set can accurately detect suspicious behavior. This method permits for the allocation of multiple log source types through a sliding time window and provides a scalable solution, which is a much-needed function.…”
Get full text

ANALISIS STAKEHOLDERS DALAM PENGEMBANGAN PROGRAM DIKLAT DI BALAI DIKLAT APARATUR KEMENTERIAN KELAUTAN DAN PERIKANAN STAKEHOLDERS ANALYSIS IN DEVELOPMENT OF TRAINING PROGRAM ON TRAI... by Yudistira Adi Nugroho

“…Data retrieval is done by means of field research through interviews with several informants. The selection of informants is based on purposive sampling technique, namely the technique of selecting informants to get data sources based on people who are considered to know the best about what the researchers expect. …”
Get full text

ANALISIS STAKEHOLDERS DALAM PENGEMBANGAN PROGRAM DIKLAT DI BALAI DIKLAT APARATUR KEMENTERIAN KELAUTAN DAN PERIKANAN STAKEHOLDERS ANALYSIS IN DEVELOPMENT OF TRAINING PROGRAM ON TRAI... by Yudistira Adi Nugroho

“…Data retrieval is done by means of field research through interviews with several informants. The selection of informants is based on purposive sampling technique, namely the technique of selecting informants to get data sources based on people who are considered to know the best about what the researchers expect. …”
Get full text

Re-Infection Outcomes Following One- And Two-Stage Surgical Revision of Infected Knee Prosthesis: A Systematic Review and Meta-Analysis. by Setor K Kunutsor, Michael R Whitehouse, Erik Lenguerrand, Ashley W Blom, Andrew D Beswick, INFORM Team

“…<h4>Design</h4>Systematic review and meta-analysis.<h4>Data sources</h4>MEDLINE, EMBASE, Web of Science, Cochrane Library, reference lists of relevant studies to August 2015, and correspondence with investigators.…”
Get full text

Pollution Characteristics and Water Quality Status of Water Storage Pond in Xianyang City of Shaanxi Province by Zhou Fuyu, Gao Zhaoliang, Zhang Shuai, Li Yonghong, Sun Guanfang, Lou Yongcai, Ai Jianwei, Liu Wenbo

“…Treatment methods suitable for the rural environment should be selected according to the characteristics of water pollution.…”
Get full text

Recent Advances and Challenges in the Production of Hydroxylated Natural Products Using Microorganisms by Chang Sun, Rumei Zeng, Tianpeng Chen, Yibing Yang, Yi Song, Qiang Li, Jie Cheng, Bingliang Liu

“…Hydroxylation reaction is a significant source of structural diversity in natural products (NPs), playing a crucial role in improving the bioactivity, solubility, and stability of natural product molecules. …”
Get full text

High-Sensitivity Determination of K, Ca, Na, and Mg in Salt Mines Samples by Atomic Emission Spectrometry with a Miniaturized Liquid Cathode Glow Discharge by Jie Yu, Zhichao Zhang, Quanfang Lu, Duixiong Sun, Shuwen Zhu, Xiaomin Zhang, Xing Wang, Wu Yang

Get full text

Performance of the HAWC Observatory and TeV Gamma-Ray Measurements of the Crab Nebula with Improved Extensive Air Shower Reconstruction Algorithms by A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, C. de León, D. Depaoli, N. Di Lalla, R. Díaz Hernández, B. L. Dingus, M. A. DuVernois, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, H. Goksu, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, S. Kaufmann, A. Lara, J. Lee, H. León Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafá, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, X. Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou, HAWC Collaboration

“…Thanks to these improvements, HAWC can now detect more sources, including the Galactic center.…”
Get full text