HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors by Viet-Khoa Tran-Nguyen, Ulrick Fineddie Randriharimanamizara, Olivier Taboureau

“…It also demonstrated superior screening power compared to virtual screening schemes that used existing scoring functions. This model, named “HERGAI,” along with relevant input/output data and user-friendly source code, is available in our GitHub repository ( https://github.com/vktrannguyen/HERGAI ) and can be used to predict drug-induced hERG blockade, even on large data sets.…”
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Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection. by Alex J McCarthy, David Negus, Patricia Martin, Catarina Pechincha, Eric Oswald, Richard A Stabler, Peter W Taylor

“…Only four single nucleotide polymorphisms (SNPs), in genes (gloB, yjgV, tdcE) or promoters (thrA) involved in metabolic functions, were found: no changes were detected in genes encoding virulence determinants associated with the invasive potential of E. coli K1. …”
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Research review of digital modeling technologies with 3D spatial visualization for pipelines by Xin LIU, Shengwen TU, Yanfang HOU, Dong LIN, Jie SHU, Yu TANG

“…These developments have resulted in more comprehensive functionalities for visualization systems and improved operational and maintenance efficiency. …”
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Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study by Kangjie li, Jie Wang, Ming Dang, Runxin Ren, Maomao Fu, Jing Wang, Qiao Zhang, Chongbo Zhao

“…Additionally, expanding the data sources for further analysis is crucial. However, this study has limitations, including reliance on a limited selection of databases and keywords from Web of Science, which may not capture all relevant literature, and the potential bias in the bibliometric analysis.…”
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Quand l’écriture entre dans le quotidien : les mots de la mémoire dans les livres de raison (Provence, fin xve-xviiie siècles) by Isabelle Luciani

“…This lexicon is correlated with the functions of memory aids and records (these books of reason could be used as evidence in court), which allows us to question the way words and signs functioned in memory techniques (repetitions, reformulations, mnemonic use of genealogies, reference to historical events, etc.) developed by scribblers often unfamiliar with the learned “arts of memory”. …”
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Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
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GASTROINTESTINAL BLEEDING WITH THE USE OF NEW ORAL ANTICOAGULANTS: EPIDEMIOLOGY, RISK FACTORS, TREATMENT, AND PREVENTION by E. V. Moroz, A. E. Karateev, E. V. Kryukov, V. A. Chernetsov

“…Novel oral anticoagulants (NOACs), such as the direct thrombin inhibitor dabigatran and the selective factor Xa inhibitors rivaroxaban and apixaban, are increasingly used as an effective antithrombotic drug in real clinical practice. …”
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REGULATORY INTEGRATION IN THE HEALTHCARE SECTOR OF UKRAINE by Mykhailo D. Diachuk

“…Materials and methods. 20 regulatory and legal documents and 16 scientific literary sources on the topic of the research materials were selected. …”
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Live and heat-killed Leuconostoc mesenteroides counteract the gastrointestinal dysfunction in chronic kidney disease mice through intestinal environment modulation. by Fittree Hayeeawaema, Natthawan Sermwittayawong, Chittipong Tipbunjong, Nawiya Huipao, Paradorn Muangnil, Pissared Khuituan

“…This study aimed to evaluate the probiotic potential of lactic acid bacteria derived from natural sources and to investigate the effects of both live and heat-killed Leuconostoc mesenteroides (Ln.m) on renal and gastrointestinal functions in CKD mice. …”
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Sunlight Noise Mitigation in FMCW LiDAR Using FADOF by Longfei Yin, Wei Tang, Ziwei Geng, Haodi Zhan, Lei Chen, Dasheng Qian, Guohua Wu, Bin Luo

“…Additionally, the system achieves a detection range of at least 17 meters under direct sunlight conditions. …”
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An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies by Chenfang Miao, Menghan Zhang, Ying Zheng, Xiaoyan Lin, Shuangying Yang, Linlin Xu, Sitong Lu, Zhengjun Huang, Jianyong Huang, Yanjie Zheng, Shaohuang Weng

“…However, efficient and sensitive detection methods remain limited. In this study, high quantum yield carbon dots (CA/EDA-CDs) were synthesized via a hydrothermal method using riboflavin as the carbon source, citric acid and ethylenediamine as functionalizing agents and dopants. …”
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Submillimeter and Mid-infrared Variability of Young Stellar Objects in the M17 H II Region by Zhiwei Chen, Doug Johnstone, Carlos Contreras Peña, Jeong-Eun Lee, Sheng-Yuan Liu, Gregory Herczeg, Steve Mairs, Geumsook Park, Kee-Tae Kim, Mi-Ryang Kim, Keping Qiu, Yao-Te Wang, Xu Zhang, Megan Reiter, The JCMT Transient Team

“…This mid-IR fractional variability as a function of evolutionary stage result is similar to what has previously been found for YSO variability within the Gould Belt and the intermediate-mass star formation region M17 SWex, though overall less variability is detected in M17 in submillimeter and mid-IR. …”
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Targeting Amyloid Pathology in Early Alzheimer’s: The Promise of Donanemab-Azbt by Nadia Khartabil, Ayda Awaness

“…It specifically targets and reduces amyloid beta plaques, a hallmark of the disease, potentially slowing progression and preserving cognitive function. However, its administration requires careful patient selection, including genetic testing for ApoE ε4 status, to mitigate risks of ARIA. …”
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Cost-Effective Photoacoustic Imaging Using High-Power Light-Emitting Diodes Driven by an Avalanche Oscillator by Alberto Prud’homme, Frederic Nabki

“…While lasers have traditionally been the light source for PAI, their high cost and complexity drive interest towards alternative sources like light-emitting diodes (LEDs). …”
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Two rare cases of severe community-acquired bloodstream infections: a clinical case report by Li-Na Meng, Gang Li

“…Detailed medical history inquiries, assessment of underlying immune status, detection of the source of infection, and initial precise identification and treatment of the infectious agents can improve the prognosis of CABSI.Case descriptionIn this paper, two incidences of severe CABSI with insidious onset and rapid progression are described. …”
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Rehabilitation impact indices and their independent predictors: a systematic review by Amardeep Thind, Gerald Choon-Huat Koh, Robert Petrella, Cynthia Huijun Chen

“…Objectives To (1) identify all available rehabilitation impact indices (RIIs) based on their mathematical formula, (2) assess the evidence for independent predictors of each RII and (3) propose a nomenclature system to harmonise the names of RIIs.Design Systematic review.Data sources PubMed and references in primary articles.Study selection First, we identified all available RII through preliminary literature review. …”
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PhotoNeuro: A compact photodetector for synchronization of visual stimulus presentation during behavioural experiments in neuroscience by Xavier Cano-Ferrer, Marcelo J. Moglie, George Konstantinou, Antonin Blot, Gaia Bianchini, Albane Imbert, Petr Znamenskiy, M. Florencia Iacaruso

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3D-MRI brain glioma intelligent segmentation based on improved 3D U-net network. by Tingting Wang, Tong Wu, Defu Yang, Ying Xu, Dongyang Lv, Tong Jiang, Hengjiao Wang, Qi Chen, Shengnan Xu, Ying Yan, Baoguang Lin

“…This method offers significant guidance for medical diagnosis, grading, and treatment strategy selection.<h4>Methods</h4>Glioma case data were sourced from the BraTS2023 public dataset. …”
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A probabilistic approach for building disease phenotypes across electronic health records by David Vidmar, Jessica De Freitas, Will Thompson, John M. Pfeifer, Brandon K. Fornwalt, Noah Zimmerman, Riccardo Miotto, Ruijun Chen

“…In this paper, we develop multiple heuristic “labeling functions’’ (LFs) for 4 diseases across de-identified EHR data and aggregate their votes through a majority vote approach (MV), a popular open-source approach (Snorkel OSS), and our proposed probabilistic approach (LEVI). …”
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Classification analysis of modern bioreactor systems (review). Part 1. Classification of bioreactors by design parameters by A. A. Dosaev, R. R. Safarov, N. V. Menshutina

“…Due to the active use of bioreactors, in order to optimize production processes and reduce operating costs, new highly efficient automated devices with a variety of functions are being developed using modern automation technologies, artificial intelligence and 3-D printing. …”
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