Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

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Isolation and Characterization of L-Asparaginase-Producing Bacteria from the Arabian–Persian Gulf Region: First Report on <i>Bacillus xiamenensis</i> ASP-J1-4 as a Producer and Its... by Ghofran M. Al-Harbi, Essam Kotb, Abeer A. Almiman, Mahmoud M. Berekaa, Salwa Alhamad, Nada F. Alahmady, Meneerah A. Aljafary, Nadiyah M. Alqazlan, Reem I. Alyami, Joud M. Alqarni, Ebtesam Abdullah Al-Suhaimi

“…L-asparaginase (L-ASNase) functions as a chemotherapeutic enzyme with antitumor properties. …”
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Trade-offs and synergies for urban Production-Living-Ecological spatial Patterns-Comparison study between Fuzhou, China, and Saskatoon, Canada by Xi Wang, Xiaomei Li, Jinming Sha, Hao Zhang, Eshetu Shifaw, Xulin Guo, Shuhui Lai, Jinliang Wang

“…First, the paper identified the PLE spaces by integrating multi-source data, then analyzed the PLE spatial agglomeration characteristics by using the average nearest neighbor and kernel density analysis, finally detected the trade-offs and synergies between functional spaces by Spearman correlation and bivariate spatial autocorrelation. …”
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Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins by Ruolan Yi, Jiaoyang Zheng, Zhichao Xu, Jiayan Wu, Fangfang Liu, Jinxin Zheng, Duoyun Li, Shiqing Han, Zhijian Yu

“…Additionally, while the growth adaptation of K2044−8Xyl−60G under xylose pressure was confirmed, no amino acid mutations were detected in the functional proteins of this xylose-induced isolate, suggesting that persistent xylose pressure does not cause nonsense mutations in the bacterial genome. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection by Zonglei Zhou, Jie Tian, Yuying He, Haiyan Xiong, Weibing Wang

“…ABSTRACT Tuberculosis (TB) stages depend greatly on the interaction between Mycobacterium tuberculosis (Mtb) and the host response. As a non-negligible source of active tuberculosis (ATB), individuals with latent Mtb infection (LTBI) are insidious and hard to be detected due to limited biomarkers. …”
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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer by Qing Wang, Maha Ayyoub, Olivia Le Saux, Paola Bonaventura, Isabelle Treilleux, Nicolas Chopin, Clarisse Dubois, Virginie Mutez, Nicolas Chuvin, Yann Estornes, Jenny Valladeau-Guilemond, Stephane Depil, Nicolas Gadot, Marie Michelas, Audrey Page, Olivier Tabone, Marie Delles, Sarah Moran, Thibault Richard, Marjorie Lacourrège, Dina M Tawfik, Ema Etchegaray, Adrian Valente, Rasha E Boulos, Gabriel Jimenez Dominguez

“…A specific immunopeptidomics approach was developed to detect epitopes on human leukocyte antigens (HLA) molecules. …”
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Metallurgical Waste for Sustainable Agriculture: Converter Slag and Blast-Furnace Sludge Increase Oat Yield in Acidic Soils by Olga V. Zakharova, Peter A. Baranchikov, Svetlana P. Chebotaryova, Gregory V. Grigoriev, Nataliya S. Strekalova, Tatiana A. Grodetskaya, Igor N. Burmistrov, Sergey V. Volokhov, Denis V. Kuznetsov, Alexander A. Gusev

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Epidemiology of Disability of Adult Population in the Russian Federation by S. N. Puzin, M. A. Shurgaya, N. V. Dmitrieva, G. E. Pogosyan, I. V. Lyalina, A. M. Mammaraeva, T. A. Ivanova, L. S. Idrisova

“…In one elderly patient older than 60 years, on average, four to five different chronic diseases are detected. The accumulation of impaired functions of organs and systems helps to reduce the adaptive capacity of the body and is associated with limited life, which entails an increase in the risks of disability in the elderly and the need for medical and social rehabilitation. …”
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Growth Toxic Effects of Metal Nanoparticles on Bacillus subtilis and Vibrio parahaemolyticus by Shiyu CHEN, Bin XIA, Lin ZHU, Shuang LI, Qiufen LI, Xuemei SUN, Wei DAI

“…Based on the ecological roles and functions of these two bacteria in marine microbial communities, this study used B. subtilis and V. parahaemolyticus isolated from Bohai Bay as test organisms. …”
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تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"... by محمود سليمان, ولاء زقدان

“…Where the mass media vision of architecture and construction is limited to the notion th athousing projects are merely architectural designs imbedded within investment enterprises, that target profit at the first place, and that such projects are no longer inconsistent compliance with the basic needs of the units users, in terms of: functional spaces, the social or environmental needs, in accordance with the community's cultureand its distinctive characteristics.Consequently, this research sheds light on the influence exercised by the mass media on the society's culture, consciousness, awareness, and perception of the essence ofarchitecture and settlement. …”
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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…In the present study, we show that replacing ECB balance sheet size with random numbers leads to statistically indistinguishable shock response functions and time series of abnormal monetary policy shocks. …”
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Native bacteria from a Mediterranean greenhouse associated to soil health and suppressiveness by Jose Ignacio Marín-Guirao, Miguel de Cara-García

“…Among the 52 ecological pathways detected via FAPROTAX database, nitrogen-related functions showed higher presence at the end of the cropping seasons. …”
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Molecular organization of the nanoscale surface structures of the dragonfly Hemianax papuensis wing epicuticle. by Elena P Ivanova, Song Ha Nguyen, Hayden K Webb, Jafar Hasan, Vi Khanh Truong, Robert N Lamb, Xiaofei Duan, Mark J Tobin, Peter J Mahon, Russell J Crawford

“…The molecular organization of the epicuticle (the outermost layer) of insect wings is vital in the formation of the nanoscale surface patterns that are responsible for bestowing remarkable functional properties. Using a combination of spectroscopic and chromatographic techniques, including Synchrotron-sourced Fourier-transform infrared microspectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS) depth profiling and gas chromatography-mass spectrometry (GCMS), we have identified the chemical components that constitute the nanoscale structures on the surface of the wings of the dragonfly, Hemianax papuensis. …”
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Elevated heterotrophic activity in Guaymas Basin hydrothermal plumes influences deep-sea carbon cycling by Andrew Montgomery, Guang-Chao Zhuang, Zhichao Zhou, Marguerite V. Langwig, María del Carmen Millán-Motolinía, Hannah Y. L. Choi, Kimberley S. Hunter, Carlos A. Mortera-Gutiérrez, Christelle Hyacinthe, Zachary Marinelli, Karthik Anantharaman, Andreas Teske, Samantha B. Joye

“…Metatranscriptomic analysis of functional genes for heterotrophic metabolisms implicates Gammaproteobacteria and diverse heterotrophs in hydrothermally-sourced organic carbon degradation. …”
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Inference of a plume conduit beneath the Réunion Island from 3D migration of Ps conversions from the mantle transition zone by B. Padma Rao, M. Ravi Kumar

“…In this study, we investigate the mantle transition zone (MTZ) structure beneath the Réunion Island using 3D-migration of P-Receiver functions, to decipher the effect of the plume on the MTZ and its architecture. …”
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Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. It plays a key role in tumor growth by governing gene expression. …”
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MULTI-MODEL STACK ENSEMBLE DEEP LEARNING APPROACH FOR MULTI-DISEASE PREDICTION IN HEALTHCARE APPLICATION by Bhaskar Adepu, T. Archana

“…These datasets serve two functions: improving illness prediction and examining large data reservoirs to identify previously unknown disease patterns. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…The key findings in this segment were: Organizational The practice of reuse currently functions as an appendix of the demolition industry, bringing benefits as well as disadvantages. …”
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Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Functional dispersion (FDis) and taxonomic diversity (Delta) correlating significantly with all diversity dimensions (r=0.36-0.90; p&lt;0.05) and outperforming species richness in detecting environmental responses. …”
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