Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement by Sen Luo, Xi Zhou, Meijing Wu, Gongxin Wang, Li Wang, Xujun Feng, Hang Wu, Ren Luo, Minjuan Lu, Junxian Ju, Wenxing Wang, Lei Yuan, Xiaoqing Luo, Dezheng Peng, Li Yang, Qingfeng Zhang, Minzhi Chen, Songping Liang, Xiuming Dong, Guoliang Hao, Yunxiao Zhang, Zhonghua Liu

“…Spider venom‐derived peptide toxins are recognized as significant sources of Nav1.7 inhibitors. However, their development has been impeded by limited selectivity. …”
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Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin by Bayazit Yunusbayev, Anna Bogdanova, Nadezhda Nadyrchenko, Lavrentii Danilov, Viktor Bogdanov, Grigory Sergeev, Radick Altinbaev, Fanil Bilalov, Milyausha Yunusbaeva

“…We next showed that these enriched species were correlated with elevated biomarkers of intestinal and systemic inflammation and liver function. Functionally, one of the top species, Megasphaera elsdenii, is a potent lactate utilizer in the context of intestinal lactic acidosis and inflammation. …”
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Complexation with Alginate in Pumpkin Leaf Protein Solutions for the Encapsulation of Folic Acid: The Effect of Extraction Protocols by Predrag Petrović, Bojana Balanč, Jelena Mijalković, Tamara Đukić, Stefan Bošković, Verica Đorđević, Branko Bugarski, Viktor Nedović, Zorica Knežević-Jugović

“…This study aimed to assess pumpkin leaves as a protein source and determine the feasibility of these proteins to form complexes with alginate for the encapsulation of folic acid. …”
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Comparative metabolomic profiling of Lupinus albus and L. angustifolius harvest residues: exploring chemical diversity and valorization potential by Salma Halime, Salma Halime, Jenny Renaut, Stéphanie Zimmer, Hanna Heidt, Cédric Jacquard, Kjell Sergeant

“…Lupin species are a rich source of bioactive compounds with diverse industrial applications, yet their harvest residues remain underutilized. …”
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Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria by Candice L. Wilshire, Carson C. Fuller, Christopher R. Gilbert, John R. Handy, Kimberly E. Costas, Brian E. Louie, Ralph W. Aye, Alexander S. Farivar, Eric Vallières, Jed A. Gorden

“…The electronic medical record (EMR) is a source of clinical information that could identify high-risk populations for LCS, including a diagnosis of COPD; however, an unsubstantiated COPD diagnosis in the EMR may lead to inappropriate LCS referrals. …”
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Evaluation of the effect of irrigation with purified wastewater on the physical and chemical properties of soil by Sadegh Partani, Seyed Mohammad Reza Madany, Mir Hassan Seyed Seraji

“…Also, the growth rate of the organs as a function of the treatment conditions during the experiment had a significant difference. …”
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Canopy Chlorophyll Content Inversion of Mountainous Heterogeneous Grasslands Based on the Synergy of Ground Hyperspectral and Sentinel-2 Data: A New Vegetation Index Approach by Yi Zheng, Yao Wang, Tayir Aziz, Ali Mamtimin, Yang Li, Yan Liu

“…This study confirms that the synergistic use of multi-source data effectively overcomes the limitations of the spectral–spatial resolution of a single data source, providing a novel methodology for the precision monitoring of mountain ecosystems.…”
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Antioxidant and Anti-Inflammatory Activities of Cutlassfish Head Peptone in RAW 264.7 Macrophages by Su-Jin Lee, Jeonghyeon Im, Svini Dileepa Marasinghe, Eunyoung Jo, Minthari Sakethanika Bandara, Youngdeuk Lee, Jaewon Lee, Gun-Hoo Park, Chulhong Oh

“…CP suppressed the expression of inflammatory mediators, including inducible nitric oxide synthase (iNOS) and cyclooxygen-ase-2, and selectively inhibited the pro-inflammatory cytokines interleukin (IL)-1β and IL-6. …”
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Environmental sustainability of cotton: a systematic literature review of life cycle assessments by Giuseppe Salvatore Vitale, Nicolò Iacuzzi, Silvia Zingale, Sara Lombardo, Teresa Tuttolomondo, Paolo Guarnaccia

“…This review analyzes twenty peer-reviewed studies on cotton life cycle assessments, selected from Scopus and Web of Science according to PRISMA guidelines and covering the period 2010–2022. …”
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Visualization of four-dimensional X-ray absorption fine structure data using a virtual reality system by Haruo Igarashi, Daiki Kido, Yutaka Ishii, Yasuhiro Niwa, Atsushi Okamoto, Masao Kimura

“…Our 4D-XASView facilitates the visualization and analysis of the geometric and topological aspects of the data using VR goggles, enabling detailed exploration of microstructures via rotation and zooming functionalities. This capability allows us to extract XAFS spectral data by selecting specific positions and regions, thereby aiding in the identification of `trigger sites' (magnetite in serpentine), which are characteristic locations within materials that substantially influence the macroscopic propagation of reactions. …”
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Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
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Senegalin-2: A Novel Hexadecapeptide from <i>Kassina senegalensis</i> with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a Bradykinin Antagonist by Yueyang Lu, Yanguo Zhu, Chengbang Ma, Lei Wang, Mei Zhou, Tianbao Chen, Xiaonan Ma, Xu Zhang, Zhimin Fan

“…The amphibian skin secretions are excellent sources of bioactive peptides, some of which and their derivatives exhibit multiple properties, including antibacterial and antagonism against bradykinin. …”
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Erythrina lysistemon Hutch. abates deranged metabolic indices linked with diabetic complications in experimental rat model by Kolawole Olofinsan, Veronica Salau, Ochuko Erukainure, Md. Shahidul Islam

“…This study investigated the in vivo activity of E. lysistemon bark extract on animal models of type 2 diabetes (T2D) and complications vis-a-vis the effects on pancreatic functional enzymes and morphology, serum biochemical profile, and hepatic glucose metabolism. …”
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Current Perspectives on Anorexia Nervosa in Health and Therapy - a review by Wojciech Bieńkowski, Julia Charkot, bartlomiej kusy, Michał Bieńkowski, Mikołaj Charkot, Piotr Kucharczyk, Irmina Jaszczuk, Patrycja Retman

“…Material and method: A narrative literature review was conducted using publications from 2010 to 2024, sourced from databases such as PubMed, Scopus, and Web of Science. …”
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In vitro regeneration and phytochemical evaluation of pippali (Piper longum) for conservation and therapeutic applications by ARIJITA MOHANTY, JYOTI PRAKASH SAHOO, KAILASH CHANDRA SAMAL

“…Infrared (IR) absorption analysis identified functional groups such as alcohols, amides, alkanes and carboxylic acids. …”
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Mineral composition in mussel Mytilus galloprovincialis and clam Tapes decussatus from Faro Lake of Messina: risk assessment for human health by Fabio Bruno, Vincenzo Nava, Sebastiano Zappalà, Giovanna Lucrezia Costa, Francesco Fazio, Vincenzo Parrino, Patrizia Licata

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Neonatal Microcephaly and Central Nervous System Abnormalities During the Zika Outbreak in Rio de Janeiro by Marlos Melo Martins, Roberto de Andrade Medronho, Carlos Eduardo Raymundo, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha

“…Ophthalmologic abnormalities were detected in 55.5% of cases, and brainstem auditory evoked potential anomalies were reported in 33.3%. …”
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Solar background radiation temperature calibration of a pure rotational Raman lidar by V. Jayaweera, R. J. Sica, G. Martucci, A. Haefele, A. Haefele

“…It also allows a lidar not co-located with a routine external source to be continuously calibrated once an initial external calibration is done. …”
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Canopy Transpiration Mapping in an Apple Orchard Using High-Resolution Airborne Spectral and Thermal Imagery with Weather Data by Abhilash K. Chandel, Lav R. Khot, Claudio O. Stöckle, Lee Kalcsits, Steve Mantle, Anura P. Rathnayake, Troy R. Peters

“…In addition, weather information for estimating ET is very often selected from sources that do not represent conditions like heterogeneous site-specific conditions. …”
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Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review by Angela Ju, Karine Manera, Armando Teixeira-Pinto, Germaine Wong, Martin Howell, Adeera Levin, Chandana Guha, David C Wheeler, Allison Jauré, Anastasia Hughes, Rosanna Cazzolli, Luca G Torrisi, Rebecca Wu

“…The characteristics, dimensions of fatigue and psychometric properties of these measures were extracted and analysed.Data sources We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023.Eligibility criteria for selecting studies All studies that reported fatigue in patients with CKD stages 1–5 not receiving KRT.Results We identified 97 studies (20 (21%) randomised trials, 2 (2%) non-randomised trials and 75 (77%) observational studies). 27 different measures were used to assess fatigue, of which three were author-developed measures. …”
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