Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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Biomechanical Changes to the Ankle After Zadek Osteotomy by Nicholas Bellas MD, Raghunandan Nayak BS, Mehreen Pasha BS, Megan R. Wolf MD, Elifho Obopilwe MS, Thomas McDonald MD, Lauren E. Geaney MD

“…Category: Hindfoot; Sports Introduction/Purpose: Insertional Achilles tendinopathy is a common source of heel pain in active adults and athletes. …”
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Acoustic Features for Identifying Suicide Risk in Crisis Hotline Callers: Machine Learning Approach by Zhengyuan Su, Huadong Jiang, Ying Yang, Xiangqing Hou, Yanli Su, Li Yang

“…Basic acoustic features (eg, Mel Frequency Cepstral Coefficients, formant frequencies, jitter, shimmer) and high-level statistical function (HSF) features (using OpenSMILE [Open-Source Speech and Music Interpretation by Large-Space Extraction] with the ComParE 2016 configuration) were extracted. …”
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Estimating the mass of tephra accumulated on roads to best manage the impact of volcanic eruptions: the example of Mt Etna, Italy by L. Mereu, L. Mereu, M. Stocchi, M. Stocchi, A. Garcia, M. Prestifilippo, L. Sandri, C. Bonadonna, S. Scollo

“…First, we analysed a sequence of 39 short-lasting and intense lava fountains detected by the X-band weather radar, applying a volcanic ash radar retrieval approach that permits us to compute the main eruption source parameters (ESPs), such MER, <span class="inline-formula"><i>H</i>_TP</span>, and GSD. …”
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Direct-fed microbials optimize ruminal fermentation, microbial ecosystem and milk quality to enhance the lactation performance of Sanhe dairy cows by Aoyu Jiang, Zixin Liu, Ziyan Yang, Shizhe Zhang, Jian Wu, Chuanshe Zhou, Zhiliang Tan

“…Dairy cows are the most important source of milk production, with billions of microorganisms present in the rumen. …”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Alistair Perry, Laura E. Hughes, Natalie E. Adams, Michelle Naessens, Niels A. Kloosterman, Matthew A. Rouse, Alexander G. Murley, Duncan Street, P. Simon Jones, James B. Rowe

“…Across bvFTD and PSP groups, the beta response to deviant stimuli (relative to standard stimuli) correlated with clinical severity, but not with atrophy of the prefrontal source region. These findings confirm the proposed importance of higher-order cortical regions, and their beta-power generators, in sensory change detection and context-updating during oddball paradigms. …”
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Whole blood RNA-seq analysis reveals the immunomodulatory effects of a supplemental multi-strain direct-fed microbial in the diet of newly weaned beef steers1 by Adekunle Ajiboye, Samanthia Johnson, Modoluwamu Idowu, Yarahy Leal, Taylor Sidney, Godstime Taiwo, Ibukun M. Ogunade, Christopher Ashwell

“…In conclusion, this study revealed that beef steers fed the PRO additive exhibited differential expression of genes related to immune function and inflammatory response, suggesting an effect on immunity and stress resilience. …”
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There is no transfer of mitochondria from donor hematopoietic cells to recipient mesenchymal stromal cells after allogeneic hematopoietic stem cells transplantation in humans by Natalya Sats, Vadim Surin, Tatiana Abramova, Aleksandra Sadovskaya, Nataliya Petinati, Nikolay Kapranov, Ksenia Nikiforova, Nina Drize, Luisa Karaseva, Olga Pokrovskaya, Larisa Kuzmina, Elena Parovichnikova

“…Mitochondria, which can be transferred between cells via nanotubes or extracellular vesicles, play a key role in the functions of mesenchymal stromal cells. In a murine model, donor hematopoietic stem and progenitor cells transfer functional mitochondria to bone marrow mesenchymal stromal cells of the recipient. …”
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Iodine deficiency as an environmental risk factor for thyroid gland diseases in animals by І. P. Ligomina, I. M. Sokulskyi, V. M. Sokolyuk, B. V. Gutyj, L. M. Soloviova

“…Of all the organs of the endocrine system, the thyroid gland is the most closely related to the environment since its structure and function largely depend on the supply of iodine from the outside. …”
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Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…We study the cold H i gas in a 1.3 Mpc section of the filament through H i 21 cm emission line observations and detect 11 H i sources, many more than expected from the H i mass function in a similar volume. …”
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A SPectroscopic Survey of Biased Halos in the Reionization Era (ASPIRE): Spectroscopically Complete Census of Obscured Cosmic Star Formation Rate Density at z = 4–6 by Fengwu Sun, Feige Wang, Jinyi Yang, Jaclyn B. Champagne, Roberto Decarli, Xiaohui Fan, Eduardo Bañados, Zheng Cai, Luis Colina, Eiichi Egami, Joseph F. Hennawi, Xiangyu Jin, Hyunsung D. Jun, Yana Khusanova, Mingyu Li, Zihao Li, Xiaojing Lin, Weizhe Liu, Romain A. Meyer, Maria A. Pudoka, George H. Rieke, Yue Shen, Wei Leong Tee, Bram Venemans, Fabian Walter, Yunjing Wu, Huanian Zhang, Siwei Zou

“…We identify eight DSFGs in seven fields at z = 4–6 through the detection of H α or [O  iii ] λ 5008 lines, including fainter lines such as H β , [O  iii ] λ 4960, [N  ii ] λ 6585, and [S  ii ] λλ 6718,6733 for six sources. …”
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Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…A complementary approach using digital biomarkers to surpass exam-based limitations for detecting physical change coupled with a direct report from participants on what their sources of suffering are could be a useful advance in reporting beneficial effects of interventions, particularly if changes track together. …”
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Identification of key genes associated with mesocotyl length through a genome-wide association study in rice by Li Xue, Li Xue, Sen Wang, Sen Wang, Qiuyu Zhang, Qiuyu Zhang, Bing Han, Di Cui, Longzhi Han, Jianxin Deng, Xiaoding Ma

“…The results provide new clues to elucidate the molecular mechanism of rice mesocotyl development and lay an important foundation for subsequent gene function verification and molecular breeding. In the future, the functions of these candidate genes will be verified by transgenic and other methods, and molecular markers will be developed for genetic improvement of drought-tolerant rice varieties.…”
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DUALZ—Deep UNCOVER-ALMA Legacy High-Z Survey by Seiji Fujimoto, Rachel Bezanson, Ivo Labbe, Gabriel Brammer, Sedona H. Price, Bingjie Wang, John R. Weaver, Yoshinobu Fudamoto, Pascal A. Oesch, Christina C. Williams, Pratika Dayal, Robert Feldmann, Jenny E. Greene, Joel Leja, Katherine E. Whitaker, Adi Zitrin, Sam E. Cutler, Lukas J. Furtak, Richard Pan, Iryna Chemerynska, Vasily Kokorev, Tim B. Miller, Hakim Atek, Pieter van Dokkum, Stéphanie Juneau, Susan Kassin, Gourav Khullar, Danilo Marchesini, Michael Maseda, Erica J. Nelson, David J. Setton, Renske Smit

“…We also detect a marginal dust emission from an X-ray-detected galaxy at z _spec = 10.07, suggesting an active coevolution of the central black hole and its host. …”
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Reconstructing real-space geometries of polyatomic molecules undergoing strong field laser-induced Coulomb explosion by Aydin Ashrafi-Belgabad, Reza Karimi, Mohammad Monfared, Kaili Tian, Parviz Parvin, Benji Wales, Éric Bisson, Samuel Beaulieu, Mathieu Giguère, Jean-Claude Kieffer, Philippe Lassonde, François Légaré, Heide Ibrahim, Joseph H. Sanderson

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3D Heisenberg universality in the van der Waals antiferromagnet NiPS3 by Rajan Plumley, Sougata Mardanya, Cheng Peng, Johannes Nokelainen, Tadesse Assefa, Lingjia Shen, Nicholas Burdet, Zach Porter, Alexander Petsch, Aidan Israelski, Hongwei Chen, Jun-Sik Lee, Sophie Morley, Sujoy Roy, Gilberto Fabbris, Elizabeth Blackburn, Adrian Feiguin, Arun Bansil, Wei-Sheng Lee, Aaron M. Lindenberg, Sugata Chowdhury, Mike Dunne, Joshua J. Turner

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Nanoprobe synchrotron X-ray fluorescence microscopy reveals selenium-rich spherical structure in mouse retinal pigment epithelium by Marta Ugarte, Kalotina Geraki, Elizabeth Bentley, Roger Cox

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Phytochemical Profiling and Antioxidant Activity of True Leaves and Cotyledons of <i>Adenocaulon himalaicum</i> by Sang-Yun Lee, Nari Yoon, Neil Patrick Uy, Chung-Ho Choi, Sanghyun Lee

“…The young leaf of <i>A. himalaicum</i> has a rich phytochemical profile and robust antioxidant activity; hence, it has potential as natural antioxidant sources for human health and valuable pharmacognosy raw materials for pharmaceutical and functional food applications.…”
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Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy by S. А. Nedospasov

“…Systemic anti-cytokine therapy is known to be accompanied by undesirable side effects, which can hypothetically be explained by the neutralization of these protective functions. Thus, we developed prototypes of TNF blockers which limit the bioavailability of this cytokine only from its main “pathogenic” source – myeloid cells. …”
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Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…The target bacterial isolate was detected in medfly when inoculated with liquid diet regardless of age, but those fed a slurry-based diet and a separate water source had less establishment. …”
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