Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised... by John Norrie, Stephen Morris, Daniel Francis McAuley, Bronagh Blackwood, Paul Dark, Matt P Wise, Anthony C Gordon, Kalliopi Kydonaki, Timothy Simon Walsh, David Hope, Christopher Weir, Gavin Perkins, Nazir I Lone, Benedict Creagh-Brown, Julia Boyd, Michael Reade, Richard Anthony Parker, Leanne M Aitken, Valerie J Page, Alasdair MacLullich, Cathrine A McKenzie, Alix Macdonald, Annabel Giddings, Lydia Emerson, Robert Glen

“…The primary outcome is time to successful extubation. Secondary ICU outcomes include delirium and coma incidence/duration, sedation quality, predefined adverse events, mortality and ICU length of stay. …”
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The Climate-forming role of the production process of the forests of Ukraine by Platon Tretyak, Nelia Lukianchuk, Hryhoriy Krynytskyy

“…Forest vegetation plays a significant climate-regulating, oxygen-producing and moisture-producing function, which has not yet been sufficiently studied. …”
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DMYTRО DONTSOV’S TEXTS IN THE ASPECT OF CORPUS LINGUISTICS AND LEXICOGRAPHY by Oksana R. Mykytyuk, Liliia V. Kharchuk

“…Increasingly, computer technologies in linguistics offer their advanced tools to process, store and select language data, which has triggered the fast development of the actual branch of linguistic studies – corpus linguistics. …”
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Alkaline-Potassium Ferrate Pretreatment Promoting Acid Production Through Co-Fermentation of Waste Activated Sludge and Corn Straw by Xintian YU, Wei ZENG

“…Clostridium, an iron-reducing bacterium, can be selectively enriched at high concentrations of Fe(Ⅲ), further enhancing its abundance. …”
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Construction of DF-1 Cell Line of Stably Expressing Cas9 Protein Mediated by Lentivirus and Verification of Its Activity by Xiaojiao LI, Xinyu ZHU, Xian ZOU, Xia YAN, Yanhua HE, Chenglong LUO

“…【Conclusion】The DF-1 cell line of stably expressing Cas9 protein with cleavage activity was successfully established, which could provide basic materials for the subsequent research on chicken functional genes on the DF-1 cell line of stably expressing Cas9 protein.…”
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TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
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Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity by Yao Zou, Wei Xiao, Dongzhou Liu, Xianyao Li, Lihua Li, Lijuan Peng, Ying Xiong, Haina Gan, Xiang Ren

“…Results UC‐MSCs, UC‐MSCs‐exo, and NOD mouse splenic T cells were successfully cultured and identified. After T cells were co‐cultured with UC‐MSCs and UC‐MSCs‐exo, both IFN‐γ and IL‐6 were decreased while IL‐10, PGE2, and TGF‐β1 were increased in transcriptional and translational levels. …”
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LH Gene Cloning, Sequence Feature Analysis and Prokaryotic Expression in Conger myriaster by Yan CHEN, Bao SHI, Chenggang WANG, Wanjun BO, Kewen YAN, Meijun TAO, Xinyu ZHAO, Xiaodong MA

“…Western blot analysis revealed that histidine tagged LH protein reacted with anti-His antibody, LH protein yielded clear bands of 26.5 kDa were detected. The observed size is in accordance with the anticipated molecular weight expression, indicating successful expression of the fusion protein carrying 6×His tag. …”
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Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Materials and Methods: This retrospective study included 65 patients (mean age: 51.2 ± 11.5 years; 21 female) with moderate CAD, selected from the Radiological Database of our hospital between May 2022 and December 2024. …”
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Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway by CAO Ya, LIU Yang, WANG Yang

“…Flow cytometry and Western blotting were used to detect the expression of stem cell marker CD133 and stemness transcription factors SOX2 and NANOG. …”
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Cinnamaldehyde supplementation in sows and their offspring: effects on colostrum and milk composition, performance, redox status and intestinal health by Junqi Jin, Shiya Liu, Qiang Zhou, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Yong Zhuo, Hefeng Luo, Xiuming Liu, De Wu, Lianqiang Che

“…Moreover, maternal CA supplementation or post-weaning CA supplementation improved nutrient digestibility, redox status, and intestinal function-related parameters of weaned piglets.…”
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Lower respiratory rate during sleep in children with Angelman syndrome compared to age-matched controls by Leo Gschwind, Sebastian Camillo Holst, David Nobbs, Florian Lipsmeier, Katalin Buzasi, Ponghatai Boonsimma, Alexander Rotenberg, Vitaliy Kolodyazhniy, Jörg Felix Hipp

“…Conclusion Our study provides the first long-term observational evidence of a persistent bradypnea-like phenotype in individuals with AS, which may have significant implications for their clinical management. The successful use of the sleep mat device as a non-invasive physiological ambulatory monitoring tool demonstrates its potential as a digital health technology for detecting respiratory abnormalities in pediatric neurodevelopmental disorders. …”
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The effect of dexmedetomidine on acute kidney injury after elective major abdominal surgery : a retrospective single-center propensity score matched study by Haibei Liu, Rong Luo, Liu Qian, Yujun Zhang, Wensheng Zhang, Juan Tan, Ling Ye

“…Conclusion In this single-center retrospective propensity-matched study, we did not detect a significant overall difference in post-operative AKI rates between patients treated with or without dexmedetomidine during major abdominal surgery. …”
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Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer by Mengdi Zhu, Jinna Lin, Haohan Liu, Jingru Wang, Nianqiu Liu, Yudong Li, Hongna Lai, Qianfeng Shi

“…Conclusions In this study, we successfully constructed a 6-gene acetylation-associated risk model for luminal breast cancer, providing a new direction and evidence for personalized treatment. …”
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Error Analysis and Compensation of 3‒PTT Parallel Robot by CHEN Mingfang, LIANG Hongjian, WEI Songpo, HE Chaoyin

“…Finally, 31 mobile platform position sampling points on both linear and circular trajectories in the workspace of the 3‒PTT parallel robot are selected for simulation and experimental verification. …”
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Designing the outsourcing model in central government organizations by Mahnaz Moradi, Morteza Ghasemi, Maryam Majidi, Gholamreza Amjadi

“…Outsourcing is related to the transfer of a complete functional department of the business or some activities of a functional department and keeping the rest of the activities of that department internally. …”
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Narva noorte väärtused ja identiteet by Andu Rämmer, Maria Žuravljova, Anne Kivimäe, Maria Anderson

“…Among them are aspirations towards a successful career, independence from parents and good looks. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…M. vastus lateralis and M. vastus intermedius). Liver and kidney function, along with endocrine parameters, were measured via blood samples pre- and post-intervention. …”
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Penilaian Daur Hidup Proses Distribusi BBM di PT Pertamina (Persero) Fuel Terminal Parepare by Putri Alifa Kholil, Mochamad Arief Budihardjo, Fuad Muhammad, Ketut Karno

“…The calculation of impact assessment is carried out using Microsoft Excel software with the CML IA Baseline method with the function unit used is 1 KL BBM.  Categories including global warming potential, ozone depletion potential, acid rain potential, and eutrophication potential were selected based on relevance to the company's activities and which included the impact of the main categories based on the Minister of Environment and Forestry Regulation No. 1 of 2021 concerning the Company Performance Rating Assessment Program and Environmental Management.  …”
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Regreening Practices and Effectiveness Evaluation for Rocky Slope Drawdown Zones in Pumped Storage Power Station Reservoirs by YANG Zhi-chao, MA Xiao-xiao, CHANG Shi-ju, TANG Yu-shuang, ZHAO Rui-yi, WAN Dan, ZHANG Qian-zhu

“…[Methods] To address the severely impaired ecological function of the drawdown zone, this study conducted systematic analysis of habitat characteristics, including hydrological patterns, bank characteristics, non-point source pollution, and plant communities. …”
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