Molecular classification of head and neck squamous cell carcinoma based on hypoxia-related genes and clinical significance of STC2 by ZHU Jianing, WANG Tiantian, ZHANG Rui, SONG Hongquan

“…Objective To construct a molecular classification system for head and neck squamous cell carcinoma (HNSCC) utilizing hypoxia-related gene (HAG) expression profiles, and to comprehensively examine the clinicopathological significance and biological functions of the hypoxia gene stanniocalcin 2 (STC2) in HNSCC. …”
Get full text

تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"... by محمود سليمان, ولاء زقدان

“…Where the mass media vision of architecture and construction is limited to the notion th athousing projects are merely architectural designs imbedded within investment enterprises, that target profit at the first place, and that such projects are no longer inconsistent compliance with the basic needs of the units users, in terms of: functional spaces, the social or environmental needs, in accordance with the community's cultureand its distinctive characteristics.Consequently, this research sheds light on the influence exercised by the mass media on the society's culture, consciousness, awareness, and perception of the essence ofarchitecture and settlement. …”
Get full text

Evaluation of microRNAs as liquid biopsy markers in adrenocortical tumors by Chrysoula Mytareli, Vassiliki Kalotychou, Alexandros Lafioniatis, Gregory Kaltsas, George N. Zografos, Athina Markou, Labrini Papanastasiou, Athanasios Fountas, Dimitra Argyro Vasilliadi, Evanthia Kassi, Evanthia Kassi, Marina Mantzourani, Anna Angelousi

“…MiR-22-3p serum levels successfully differentiated patients with Cushing syndrome from those with non-functioning ATs (area under the curve=AUC=0.800, 95% CI: 0.653–0.953, p=0.01) and controls (AUC= 0.800, 95% CI: 0.610–0.990, p=0.02). …”
Get full text

Prediction of Soil Carbon Sequestration in Rangelands Regarding the Depth and Elevation of Sample Locations using Adaptive Neuro-Fuzzy Inference System (ANFIS) (Case Study: Lar Wat... by zeinab jafarian, zhila ghorbani

“…Knowing about carbon reservoir distribution and changes for detecting the controller mechanisms of the carbon world cycle and carbon stability is vital for managing ranges. …”
Get full text

Application of Concentration-Area fractal modeling and artificial neural network to identify Cu, Zn±Pb geochemical anomalies in Hashtjin area, NW of Iran by Ali Imamalipour, Hamed Ebrahimi, Amir reza Abdollahpur

“…Autoencoder consists of two functions: an encoder function that encodes the input data into a lower-dimensional hidden layer and a decoder function that reconstructs the encoded input data. …”
Get full text

Towards interpretable drug interaction prediction via dual-stage attention and Bayesian calibration with active learning by Rongpei Li, Yufang Zhang, Heqi Sun, Shenggeng Lin, Guihua Jia, Yitian Fang, Chen Zhang, Xiaotong Song, Jianwei Zhao, Lyubin Hu, Yajing Yuan, Xueying Mao, Jiayi Li, Aman Kaushik, Dandan An, Dongqing Wei

“…While recent computational methods focus on improving prediction accuracy, they suffer from high false-positive rates (>45%) and often function as black-box models without biological interpretability. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Main outcome measures The primary outcome was diagnostic model sensitivity and specificity for detecting bladder outlet obstruction, detrusor underactivity and detrusor overactivity, with 75.0% considered minimum clinically useful performance. …”
Get full text

Structural Parameter Identification Using Multi-Objective Modified Directional Bat Algorithm by LIU Li-jun, LIN Ying-hai, SU Yong-hui, LEI Ying

“…In the Haiwen Bridge application， MOMDBA successfully identified all 14 structural parameters with a maximum relative error of 2.59%. …”
Get full text

Effect of the time factor on the hydraulic activity of mechanically activated saponin-containing powder by Marina V. Morozova, Maria A. Frolova

“…To perform potentiometric analysis, an electrode system consisting of a measuring electrode with a calcium ion detection function (pCa) and a reference electrode was used. …”
Get full text

Molecular organization of the nanoscale surface structures of the dragonfly Hemianax papuensis wing epicuticle. by Elena P Ivanova, Song Ha Nguyen, Hayden K Webb, Jafar Hasan, Vi Khanh Truong, Robert N Lamb, Xiaofei Duan, Mark J Tobin, Peter J Mahon, Russell J Crawford

“…The molecular organization of the epicuticle (the outermost layer) of insect wings is vital in the formation of the nanoscale surface patterns that are responsible for bestowing remarkable functional properties. Using a combination of spectroscopic and chromatographic techniques, including Synchrotron-sourced Fourier-transform infrared microspectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS) depth profiling and gas chromatography-mass spectrometry (GCMS), we have identified the chemical components that constitute the nanoscale structures on the surface of the wings of the dragonfly, Hemianax papuensis. …”
Get full text

Elevated heterotrophic activity in Guaymas Basin hydrothermal plumes influences deep-sea carbon cycling by Andrew Montgomery, Guang-Chao Zhuang, Zhichao Zhou, Marguerite V. Langwig, María del Carmen Millán-Motolinía, Hannah Y. L. Choi, Kimberley S. Hunter, Carlos A. Mortera-Gutiérrez, Christelle Hyacinthe, Zachary Marinelli, Karthik Anantharaman, Andreas Teske, Samantha B. Joye

“…Metatranscriptomic analysis of functional genes for heterotrophic metabolisms implicates Gammaproteobacteria and diverse heterotrophs in hydrothermally-sourced organic carbon degradation. …”
Get full text

SIMPLE: Simple Intensity Map Producer for Line Emission by Maja Lujan Niemeyer, José Luis Bernal, Eiichiro Komatsu

“…Simple can be applied to any spectral line sourced by galaxies. The Simple code is based on lognormal mock catalogs of galaxies including positions and velocities and assigns luminosities following the luminosity function. …”
Get full text

Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. It plays a key role in tumor growth by governing gene expression. …”
Get full text

Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Functional dispersion (FDis) and taxonomic diversity (Delta) correlating significantly with all diversity dimensions (r=0.36-0.90; p<0.05) and outperforming species richness in detecting environmental responses. …”
Get full text

Neonatal Microcephaly and Central Nervous System Abnormalities During the Zika Outbreak in Rio de Janeiro by Marlos Melo Martins, Roberto de Andrade Medronho, Carlos Eduardo Raymundo, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha

“…This retrospective cohort study analyzed 7870 pregnant women, including 2269 with confirmed Zika virus (ZIKV) infection and 5601 without Zika infection, along with their fetuses and newborns. Data were sourced from multiple databases in the state of Rio de Janeiro, Brazil. …”
Get full text

Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes by Praveen Patel, Rory Collins, Richard Peto, Mark Davies, Sanjiv Banerjee, David Simpson, John Anderson, Louise Bowman, Peter Scanlon, Amanda Adler, Andrew Farmer, Helen Cook, Laura Evans, Elizabeth Williamson, Louis Bolter, Jane Armitage, Peter Sandercock, Richard Gray, Nilesh Samani, Tasso Gazis, Richard Haynes, Arun Sachdev, Eric Wu, Elizabeth Wincott, Peter Sleight, Colin Baigent, Marion Mafham, Sarah Parish, Gavin Brown, Susan Hurley, Lynne Allsop, William Stevens, Theingi Aung, Allen Young, Emily Sammons, Georgina Buck, Imen Hammami, Jill Barton, Jonathan Bodansky, Roger McPherson, Lucy Fletcher, Murphy Kevin, Ryonfa Lee, Sandra Pickworth, Monica Willett, Michael Lay, Ola Murawska, Karen Melham, Jonathan Latham-Mollart, Anna Brewer, Mike Olson, Jude Kay, Alisha Griffiths, Helen Clayton, Philip Kirby, Mike Pennington, Dominic Clarke, Jenny Anslow, Alex Hallam, Jenny Witts, Sarah Egan, Alex Wharton, Amy Derbyshire, Katherine Hepplestone, Sujit Mithra, Su Oliver, Pauline Wiatrak-Olszewska, Kelly Alvey, Nick Gregory, Priyai Parkinson, Prema Maharajan, Rachel McFee, Donna Sowter, John Featonby, Richard Furnival, Helen Lipinski, Hazel Benjamin, Tanisha McAfee, Emma Payne Payne, Liz Still

“…Reports of AMD diagnoses were sourced from 6 monthly ASCEND follow-up questionnaires and a Visual Function Questionnaire.Participants 15 480 UK adults at least 40 years of age with diabetes but no evident cardiovascular disease.Interventions 100 mg aspirin daily versus placebo and, separately, 1 g omega-3 FAs daily versus placebo.Main outcome measure The first post-randomisation reports of AMD.Results During 7.4 years of follow-up, 122 (1.6%) participants randomised to aspirin were reported as having AMD, compared with 138 (1.8%) randomised to placebo (rate ratio 0.88; 95% CI 0.69 to 1.12; p=0.31). …”
Get full text

Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Phase 2 – realist synthesis: Empirical and grey literature, together with online discussion boards, social media sources and blogs were used to create initial programme theories regarding service architecture. …”
Get full text

Impact-Echo Testing Methods for Determining the Defect of Cured-In-Place Pipe by Houssam Mahmoud, Lubos Pazdera

“… Non-destructive testing of cured-in-place pipe (CIPP) ensures that the liner (CIPP) has been successfully installed and that the pipe will function reliably, the Acoustic methods are used to detect cracks or leaks in pipes as the Impact-Echo (IE) method. …”
Get full text

Prokaryotic expression of Cryptosporidium parvum mucin CGD5_2060 and its role in adhesion by YANG Yimin, PAN Lingtao, ZHUANG Haohan, SUN Hongchao, YANG Yi, CHEN Xueqiu, DU Aifang

“…The purified recombinant protein CGD5_2060 and control protein were co-cultured with Caco2 cells, and their cell adhesion properties were detected by Western blotting and indirect ELISA. The prediction of CGD5_2060 protein function-related motifs revealed that the 1-19 amino acids of the protein are signal peptides, indicating that the protein is a secreted protein. …”
Get full text

Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity by Yingying Huang, Qiqi Mao, Jian He, Jing Su, Yi Peng, Wei Liang, Zixi Hu, Sufang Zhou, Xiaoling Lu, Yongxiang Zhao

“…Purified ECs (CD105+) took the function of endothelial cells, then successfully fused with DCs. …”
Get full text