Analysis of variant interactions in families with autism points to genes involved in the development of the central nervous system. by Jacek Kaczyński, Marta Pasenkiewicz-Gierula

“…The variants were used to build an ASD predictor based on an open-source machine learning library. The predictor correctly classifies over 78% of samples from a test set with an average significance level of 8.9· 10-158. …”
Get full text

Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…The target bacterial isolate was detected in medfly when inoculated with liquid diet regardless of age, but those fed a slurry-based diet and a separate water source had less establishment. …”
Get full text

Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
Get full text

INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…Materials and methods. Literary sources were reviewed on the relationship of malocclusion with the general diseases and the obtained data were analysed. …”
Get full text

Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study by Muhammad Suleman, Abrar Mohammad Sayaf, Sohail Aftab, Mohammed Alissa, Abdullah Alghamdi, Suad A. Alghamdi, Mohammed A. Alshehri, Kar Kheng Yeoh, Sergio Crovella, Abdullah A. Shaito

“…<b>Background:</b> Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p300, a critical step for promoting cancer cell survival and adaptation in hypoxic environments. …”
Get full text

The synthesis of the Gospel and life as a goal of evangelization by Stanisław Dyk

“…In implementing the priestly function, the focus was on celebrating the Eucharist, revealing it as a source of human strength and energy, a school of sacramental perception of life and appreciation of matter, as well as a space for forming a new man. …”
Get full text

(...) będę czągał sankie szniegem (...). Głosy dzieci z Domu Sierot by Wojciech Lasota

“…Selected quotations illustrate functioning of the children of the Orphans’ Home in the Polish-Jewish borderland, as well as related struggles and dilemmas, primarily on the linguistic and identity levels. …”
Get full text

Quand l’écriture entre dans le quotidien : les mots de la mémoire dans les livres de raison (Provence, fin xve-xviiie siècles) by Isabelle Luciani

“…This lexicon is correlated with the functions of memory aids and records (these books of reason could be used as evidence in court), which allows us to question the way words and signs functioned in memory techniques (repetitions, reformulations, mnemonic use of genealogies, reference to historical events, etc.) developed by scribblers often unfamiliar with the learned “arts of memory”. …”
Get full text

Who Leads Trends on Q&A Platforms? Identifying and Analyzing Trend Discoverers by Yongning Li, Lun Zhang, Ye Wu, Tianlan Wei

“…Q&A platforms are vital sources of information but often face challenges related to their high ratios of passive to active contributors, which can impede knowledge construction and information exchange on the platforms. …”
Get full text

VULVAR AND VAGINAL GRAFT VERSUS HOST DISEASE IN A PATIENT WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION by Esra Pirinççi, M. Orhan Ayyıldız, Abdullah Karakuş, Reyhan Gündüz

“…The main risk factor for the development of chronic genital GVHD issuing of peripheral blood as a source of progenitor cells; It represents a risk of three times higher than that obtained from bone marrow cells (9-11). …”
Get full text

3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…Cancer stem cells (CSCs), the primary source of therapy resistance in pancreatic ductal adenocarcinoma (PDAC), exist in a dynamic equilibrium through tumor microenvironment (TME)-driven plasticity. …”
Get full text

Net2Brain: a toolbox to compare artificial vision models with human brain responses by Domenic Bersch, Domenic Bersch, Martina G. Vilas, Martina G. Vilas, Sari Saba-Sadiya, Timothy Schaumlöffel, Timothy Schaumlöffel, Kshitij Dwivedi, Christina Sartzetaki, Radoslaw M. Cichy, Radoslaw M. Cichy, Radoslaw M. Cichy, Gemma Roig, Gemma Roig

“…Finally, the toolbox integrates seamlessly with other established open source libraries, enhancing interoperability and promoting collaborative research. …”
Get full text

Nature-based solutions for urban climate resilience: implementation, contribution, and effectiveness by Gemechis B Mosisa, Bobe Bedadi, Gemedo Dalle, Nega Tassie

“…For instance, of the 26 qualitative sample publications selected for this systematic review, almost 54 % employed only secondary data sources, and eight publications lacked clear and specified data analysis techniques. …”
Get full text

Ashbya gossypii as a versatile platform to produce sabinene from agro-industrial wastes by Gloria Muñoz-Fernández, Javier-Fernando Montero-Bullón, José Luis Martínez, Rubén M. Buey, Alberto Jiménez

“…Conclusions Engineered A. gossypii strains serve as a suitable platform for assessing plant terpene synthase functionality and substrate selectivity in vivo, which are crucial to understand monoterpene bioproduction. …”
Get full text

Thermal Characteristics Testing and Analysis of Dry Gear Hobbing Machine on Multivariate Information Fusion by Peng Shengdi, Yang Xiao, Li Benjie, He Lang, Zhang Zhili

“…Through the selection of hardware for the lower computer, the development of software functions for the upper computer, and the integration of test functions, the multi-source fusion test method for the thermal characteristics of dry-cutting and hobbing machine was constructed. …”
Get full text

„Looduse universaal-biblioteek“: raamatusarja juhtumiuuring / Universal Library by Loodus (1927–1931): a case study of the book series by Piret Pärgma

“…The series significantly expanded the selection of translated authors, making it a tool for introducing translated literature and new writers and fostering opportunities for emerging translators. …”
Get full text

Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma. by Michele Vacca, Simona D'Amore, Giusi Graziano, Andria D'Orazio, Marica Cariello, Vittoria Massafra, Lorena Salvatore, Nicola Martelli, Stefania Murzilli, Giuseppe Lo Sasso, Renato Mariani-Costantini, Antonio Moschetta

“…Twenty-nine NR transcripts were significantly modified in their expression during LR, including fatty acid (peroxisome proliferator-activated receptors, PPARs) and oxysterol (liver X receptors, Lxrs) sensors, circadian masters RevErbα and RevErbβ, glucocorticoid receptor (Gr) and constitutive androxane receptor (Car). In order to detect the NRs that better characterize proliferative status vs. proliferating liver, we used the novel Random Forest (RF) analysis to selected a trio of down-regulated NRs (thyroid receptor alpha, Trα; farsenoid X receptor beta, Fxrβ; Pparδ) as best discriminators of the proliferating status. …”
Get full text

Influência de um protocolo de criopreservação no rendimento in vitro de células-tronco derivadas do tecido adiposo Effect of a cryopreservation protocol on the in vitro yield of ad... by Fernanda Ginani, Diego Moura Soares, Carlos Augusto Galvão Barboza

“…<br>BACKGROUND: Adipose tissue obtained by liposuction may be an accessible source of stem cells for future clinical application in tissue regeneration. …”
Get full text

Cacao Agroforestry in Mahakam Ulu: Transformation Strategy from Traditional to Good Agricultural Practices and Smart Agroforestry System by Catur Budi Wiati, Eddy Mangopo Angi, Karmilasanti Karmilasanti, Murniati Murniati, Sri Suharti, Indra A.S.L.P. Putri, Aris Pudji Hadi, Muhammad Furkan, Belasius Anyeq, Krista Tala, Veronica Carolina, Awaluddin Aziz, Ria Andiana, Yuliara Limbong, Yosua Naibaho, Mukrimin Mukrimin

“…The implementation of cacao SAF is anticipated to enhance cacao productivity, improve the welfare of local communities, and preserve the forest’s function as a crucial life support system for the Dayak Community in Mahakam Ulu (Mahulu) District. …”
Get full text

State immunological reactivity and autonomic regulation in patients with chronic apical periodontitis

“…In this paper we studied 107 people with a diagnosis of «chronic apical periodontitis». The functional state of the autonomic nervous system were detected by electrophoresis dosed adrenaline and carbachol and test dermographism. …”
Get full text