CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. by Danny W K Lum, Pablo Perel, Aroon D Hingorani, Michael V Holmes

“…In analysis of treatment-only studies, the relative risk (RR) of all-cause mortality (>307 events in 4,936 patients) for carriers of a CYP2D6 reduced function allele was 1.11 (95% confidence interval (CI): 0.94 to 1.31) compared to individuals with normal/increased function CYP2D6 alleles. …”
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Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions by Hyogeun Shin, Min-Ho Nam, Seung Eun Lee, Soo Hyun Yang, Esther Yang, Jin Taek Jung, Hyun Kim, Jiwan Woo, Yakdol Cho, Youngsam Yoon, Il-Joo Cho

“…Abstract Transcranial brain stimulation is a promising technology for safe modulation of brain function without invasive procedures. Recent advances in transcranial optogenetic techniques with external light sources, using upconversion particles and highly sensitive opsins, have shown promise for precise neuromodulation with improved spatial resolution in deeper brain regions. …”
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Magistrates’ Travelling Libraries: The Circulation of Normative Knowledge in the Portuguese Empire of the Late 18th Century by Airton Ribeiro da Silva Jr.

“…The present study focuses on the lists of books of eleven magistrates appointed to judicial posts in a range of locations throughout Portuguese America between 1799 and 1807. Censorship sources allow us to identify the books chosen by these itinerant magistrates as being indispensable for the exercise of their judicial function. …”
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State of accounting methods and cost of maintenance and improving water management facilities by L.V. Syrovatchenko, T.M. Shapoval

“…The article examines the state of irrigation systems in Odessa region in terms of operation and it determines that the systems have been in function for over 20 years. It is established that the presence of obsolete equipment demonstrates the need to incur costs not only for current but also for overhaul equipment that requires the expenditure of a significant proportion of budget. …”
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Deep Reinforcement Learning-Based Distribution Network Planning Method Considering Renewable Energy by Liang Ma, Chenyi Si, Ke Wang, Jinshan Luo, Shigong Jiang, Yi Song

“…Then, a multi-objective optimization function and a corresponding reward function including construction costs, voltage deviation, renewable energy penetration, and electricity purchase costs are designed to guide the generation of network topology schemes. …”
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Wheat crop producers’ technical efficiency and its determinants in Oromia region of Ethiopia: evidence from West Shewa zone by Melkamu Girma, Abule Mehare, Mengistu Ketema

“…The stochastic Cobb-Douglas production function was estimated to measure the level of technical efficiency. …”
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HEALTHY NUTRITION AS A SYMBIOSIS OF RATIONAL NUTRITION AND PHYSICAL ACTIVITY by L. Telezhenko, P. Bilenkyi

“…Diets should be selected properly to provide a daily rate of various antioxidants. …”
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Methodological quality of multivariate prognostic models for intracranial haemorrhages in intensive care units: a systematic review by Denis Frasca, Fanny Feuillet, Maxime Leger, Raphaël Cinotti, Yohann Foucher, Jeanne Simon-Pimmel, Laetitia Bodet-Contentin, Etienne Dantan

“…We aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages.Data sources Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations, we conducted a systematic review querying Medline, Embase, Web of Science, and the Cochrane in January 2020.Study selection We included development or validation of multivariate prognostic models for severe intracerebral or subarachnoid haemorrhage.Data extraction We evaluated the articles following the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies and Transparent Reporting of multivariable prediction model for Individual Prognosis Or Diagnosis statements to assess the tools’ methodological reporting.Results Of the 6149 references retrieved, we identified 85 articles eligible. …”
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Health education interventions for individuals with visual or hearing impairment: a scoping review by Sohyun Jin, Geumbo Ko, Youngshin Song

“…Abstract Background Visual impairment refers to a deficiency in one or more functions of the visual system, while hearing impairment refers to a loss of auditory function, defined either by its impact on communication and daily activities or by clinical thresholds of hearing ability. …”
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Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…The target bacterial isolate was detected in medfly when inoculated with liquid diet regardless of age, but those fed a slurry-based diet and a separate water source had less establishment. …”
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Heterogeneously integrated light emitting diodes and photodetectors in the metal-insulator-metal waveguide platform by Kwon Kyungmok, Park Junghoon, You Jong-Bum, Yu Kyoungsik

“…Depending on its bias conditions, a metal-semiconductor-metal section can function as either a light emitting diode or a photodetector directly connected to the MIM waveguides. …”
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Current status of developments in the field of respiratory syncytial virus vaccines by Tatiana S. Kotomina

“…This was facilitated by research to identify the structure of RSV, to study the basic functions of RSV components as well as the mechanisms of innate and acquired immune responses to infection. …”
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Reinforcement Learning for Optimizing Renewable Energy Utilization in Buildings: A Review on Applications and Innovations by Panagiotis Michailidis, Iakovos Michailidis, Elias Kosmatopoulos

“…For evaluation, the paper examines and outlines the different attributes in the field considering the following: methodologies of RL; agent types; value-action networks; reward functions; baseline control approaches; RES types; BEMS types; and building typologies. …”
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rangr: An R package for mechanistic, spatially explicit simulation of species range dynamics by Katarzyna Markowska, Katarzyna Malinowska, Lechosław Kuczyński

“…Several mechanistic, spatially explicit models have been proposed to address this issue, but they do not cover the full range of potential functionalities. We present a new open‐source R package called rangr, which integrates population dynamics and dispersal into a mechanistic virtual species simulator. …”
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A novel method for accelerating surgical wound healing in rabbits by collagen extraction from carp (Cyprinus carpio) fish skin by Shahbaa Kh. Al-Taee

“…The extracted collagen was characterized by low viscosity, transparency, and a watery consistency; the functional groups of collagens were detected using Fourier Transform Infrared Spectroscopy. …”
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Unraveling the complexities: morpho-physiological and proteomic responses of pearl millet (Pennisetum glaucum) to dual drought and salt stress by Charlie Sithole, Rotondwa Rabelani Sinthumule, Joseph Lesibe Gaorongwe, Oziniel Ruzvidzo, Tshegofatso Bridget Dikobe

“…Catalytic and binding activities were the predominant molecular functions detected across treatments suggesting their central role in stress response. …”
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Greenhouse gas emissions of global construction material production by Seth Kane, Josefine A Olsson, Sabbie A Miller

“…Both construction material production and emissions are primarily driven by structural materials, such as concrete and steel. Material selection can play a key role in reducing emissions in the context of the function, with variation in emissions of structural materials per unit strength between 0.001–0.1 kg CO _2 /kg/MPa and in insulation materials per R -value/thickness of 0.018–0.14 kg CO _2 /kg/(K⋅m ^2 W ^−1 ))). …”
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Prediction of the pharmaceutical solubility in water and organic solvents via different soft computing models by A. Yousefi, k. movagharnejad

“…Molecular weight, melting point, temperature and the number of each functional group in the pharmaceutical compound and organic solvents were selected as the input variables of these three different neural network models. …”
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Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…Introduction Non-pharmacological interventions, including musculoskeletal manipulations (MMs), have been proven effective for musculoskeletal disorders.Objectives To evaluate if MMs, including osteopathic manipulation and chiropractic care, are effective to improve quality of life, pain intensity and function in older adults with musculoskeletal disorders.Design Systematic review.Data sources A systematic search was conducted on MEDLINE/PubMed, EMBASE, Scopus, Web of Science, CINAHL, Cochrane Library, from database inception up to 2 January 2025.Eligibility criteria Randomised controlled trials, controlled non-randomised trials and open label trials evaluating the efficacy and safety of MM such as osteopathic manipulation, chiropractic manipulation, myofascial release, craniosacral therapy, as monotherapy or adjunctive therapies in older people (age ≥65 years) with musculoskeletal disorders. …”
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Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model. by Walter S Mathis, Maria Ferrara, Shadie Burke, Emily Hyun, Fangyong Li, Bin Zhou, John Cahill, Emily R Kline, Matcheri S Keshavan, Vinod H Srihari

“…Marginal-delay, or the portion of overall delay attributable to a specific node, was computed as the number of days between the start dates of contiguous nodes on the PTC. Sources of delay within the network of care were quantified and patient characteristic (sex, age, race, income, insurance, living, education, employment, and function) influences on such delays were analyzed via bivariate and mixed model testing.…”
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