Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis by Jingjing Wei, Yuan Tian, Meiqi Guan, Jinshu Wei, Yong Ji, Guozhong Tao, Karl G. Sylvester

“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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Genome Mining of Terpene Synthases from Fourteen <i>Streptomyces</i> Strains by Yuanyuan Li, Xi Xiang, Zhiyuan Ren, Rui Wang, Minghui Xie, Gen Li, Xiaohui Yan, Zhilong Zhao, Zixin Deng, Min Xu, Anwei Hou

“…A total of forty-eight TPSs were identified and categorized through phylogenetic analysis, and five representative TPSs distantly related to known TPSs were selected for functional investigation. Biochemical assays revealed that TAC28_6116 is a sesquiterpene synthase producing thujopsan-2β-ol (<b>1</b>) and thujopsene (<b>2</b>), marking the first report of thujopsan-2β-ol production from a bacterial source. …”
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Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. by Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei

“…These findings provide a resource of well-characterized, high efficiency ADAR-targeting Cas9 guide RNAs suitable for genomic medicines utilizing different delivery modalities and addressing different therapeutic areas.…”
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Advanced Monte Carlo for Acquisition Sampling in Bayesian Optimization by Javier Garcia-Barcos, Ruben Martinez-Cantin

“…Optimizing complex systems usually involves costly and time-consuming experiments, where selecting the experiments to perform is fundamental. …”
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ABOUT OF THE ASSIGNING APPEARANCES TO LOCOMOTIVE CREWS by Sergey P. Vakulenko, Aleksey V. Kolin, Airat M. Nasybullin, Liliya R. Aysina

“…This optimization could improve the planning of labor resource availability with a longer-term perspective. …”
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Tracking teachers’ experience of adopting my English step to infuse differentiated instruction by Ilza Mayuni, Yinghui Chen, Ni Made Ratminingsih, Tara Mustikaning Palupi, Nurhasanah Halim

“…This digital educational resource can be modified and adhered to its contextual connection. …”
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Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics by Alessandra Glovi, Panagiota M. Kalligosfyri, Antonella Miglione, Sima Singh, Gabriella Iula, Antonio Giordano, Michelino De Laurentiis, Stefano Cinti

“…In this work, miRNA-21 was selectively detected using a complementary DNA probe modified with methylene blue, as a redox mediator, immobilized onto an AuNPs-functionalized, paper-based screen-printed electrode. …”
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Evaluation of Cloud Masking Methods using Sentinel-2 Satellite Images on Google Earth Engine: A Case Study in Vietnam by Le Minh Hang, Bui Xuan Hung, Nguyen Thi Thu Nga, Mai Phuong Pham, Nguyen Quoc Khanh

“…These include the Fmask (Function of mask) method, the Fmask CDI (Cloud Displacement Index) method, and the Fmask CSP (Cloud Score Plus) method. …”
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Biomimetic Hydrodynamic Sensor with Whisker Array Architecture and Multidirectional Perception Ability by Huangzhe Dai, Chengqian Zhang, Hao Hu, Zhezai Hu, Haonan Sun, Kan Liu, Tiefeng Li, Jianzhong Fu, Peng Zhao, Huayong Yang

“…The whisker sensor is capable of detecting a variety of hydrodynamic information, including the velocity (RMSE < 0.061 m s−1) and direction of the steady flow field, the frequency (error < 0.05 Hz) of the dynamic vortex wake, and the orientation (error < 7°) of the vortex wake source, demonstrating its extensive potential for underwater environmental perception and communication, especially in deep sea conditions.…”
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Joint Survey Processing. III. Compact Oddballs in the COSMOS Field—Little Red Dots and Transients by Yu-Heng Lin, Andreas L. Faisst, Ranga-Ram Chary, Anton M. Koekemoer, Joseph Masiero, Daniel Masters, Vihang Mehta, Harry I. Teplitz, Gregory L. Walth, John R. Weaver

“…We draw the upper limit of the AGN luminosity function Φ = 1.1 × 10 ^−7 Mpc ^3 mag ^−1 for M _UV = −21 at redshift of 6. …”
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Multiwavelength Variability Analysis of the Blazar PKS 0727-11: An ~ 168 day Quasiperiodic Oscillation in the γ-Ray by Yuncai Shen, Tingfeng Yi, Vinit Dhiman, Lisheng Mao, Liang Dong

“…It is the first time that periodic variations have been detected in this source, and further supported by other methods: weighted wavelet z -transform, phase dispersion minimization, REDFIT, autoregressive integrated moving average model, and structure function analysis. …”
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A Framework for Qualitative Analysis of Switching Techniques of Inductive Pulse Power Supply by Ayaz Ahmed, Zulkurnain Abdul-Malek, Hasmat Malik, Majed A. Alotaibi

“…The purpose of this work is to serve as a valuable resource for academics and professionals interested in conducting more studies on the topic&#x2019;s practical implications for IPPS.…”
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Macroscopic-Level Collaborative Optimization Framework for IADS: Multiple-Route Terminal Maneuvering Area Scheduling Problem by Chaoyu Xia, Minghua Hu, Xiuying Zhu, Yi Wen, Junqing Wu, Changbo Hou

“…To demonstrate the applicability and effectiveness of the proposed scheduling models, a hub airport—Chengdu Tianfu International Airport (ICAO code: ZUTF) in the Cheng-Yu Metroplex—is selected for validation. Numerical analyses confirm the superiority of the proposed models, which are expected to reduce aircraft delays, shorten airborne and holding times, and improve airspace resource utilization. …”
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Current status of transcriptome sequencing technology in ruminants by Cui JiaYu, Song Lili, Wang Dawei, Liu ZhiLin, Zhang Xin, Jia Zelin, Zhang Yuhang, Xiong Huisheng, Wang Xueli

“…During the lactation stage of ruminants, transcriptome sequencing is used to screen for differentially expressed genes in blood tissue, which can identify candidate functional genes for milk production traits. Transcriptome sequencing can detect genes with low expression levels, identify new gene transcripts and alternative splicing events, detect and analyze the biological regulatory mechanisms of the body, reveal differences in gene expression levels during breeding, and reveal the interaction between hosts and pathogens. …”
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Discovery of Genomic Targets and Therapeutic Candidates for Liver Cancer Using Single-Cell RNA Sequencing and Molecular Docking by Biplab Biswas, Masahiro Sugimoto, Md. Aminul Hoque

“…This study aims to uncover key genomic features, analyze their functional roles, and propose potential therapeutic drugs identified through molecular docking, utilizing single-cell RNA sequencing (scRNA-seq) data from liver cancer studies. …”
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User Communities — Drivers for Open Innovation by Gunnar Prause, Thomas Thurner

“…Users best judge what will lead to commercial success, and they have long been recognized as a valuable source of knowledge to harvest for future innovation. …”
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Regeneration of Two-Walled Infrabony Periodontal Defects in Swine After Buccal Fat Pad-Derived Dedifferentiated Fat Cell Autologous Transplantation by Daisuke Akita, Naoki Tsukimura, Tomohiko Kazama, Rie Takahashi, Yoshiki Taniguchi, Jin Inoue, Ayana Suzuki, Nodoka Tanabe, Keisuke Seki, Yoshinori Arai, Masatake Asano, Shuichi Sato, Yoshiyuki Hagiwara, Koichiro Kano, Masaki Honda, Taro Matsumoto

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Plasmonic optical fiber biosensors for ultra-low detection of respiratory syncytial virus via point-of-care tests by Federica Passeggio, Luigi Zeni, Massimiliano Galdiero, Francesco Arcadio, Carla Zannella, Anna De Filippis, Chiara Marzano, Ines Tavoletta, Fabiana Napolitano, Rosalba Pitruzzella, Giuseppe Portella, Nunzio Cennamo

“…This protein was selected because it is the most conserved surface protein between the two RSV subtypes, RSV A and RSV B. …”
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Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons by Kishoree K. Kumaree, James M. Brimson, Kanika Verma, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab

“…Abstract Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. …”
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Economics of Plantain Production among Farmers in Northeast Nigeria by Love Joel, Abubakar Alhaji Umaru Jongur, Elizabeth Femi Adebayo, Amurtiya Michael

“…The specific objectives of the study were to; describe plantain farmers’ socio-economic characteristics in Northeast Nigeria; identify factors affecting plantain production in the study area, and also ascertain farmers’ resource use efficiency in plantain production. The study adopted a multi-stage sampling technique to collect primary data from 250 plantain farmers selected from 13 communities. …”
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