Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
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Chromosome-level genome assembly of Phortica okadai, a vector of Thelazia callipaeda by Lingjun Wang, Hongsong Yu, Bo Luo, Rong Yan, Juan Zhou, Hui Liu, Ze Zhang, Wei Sun

“…Additionally, 302 rRNAs, 377 tRNAs, 52 miRNAs, 40 snRNAs and 21 snoRNAs were detected. In conclusion, this high-quality chromosome level reference genome will be a valuable resource for furthering the fields of ecology, genetics, evolution and functional genomics of P. okadai.…”
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Transparency of social-economic determinants in developing the efficient public healthcare system by Svitlana Kolomiiets, Anna Buriak, Maksym Fritsak

“…A thorough bibliometric analysis of the social-economic public healthcare determinants and their transparency in the 2013-2023 Scopus sources is conducted stepwise. Firstly, we select a list of keywords for the studied issue. …”
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The Effect of Processing of Hempseed on Protein Recovery and Emulsification Properties by Anne Pihlanto, Markus Nurmi, Nora Pap, Jarkko Mäkinen, Sari Mäkinen

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Advanced Suspension Techniques in Interferometric Gravitational Wave Detectors: An Overview by Vishnu G. Nair

“…This isolation is crucial for enabling the detectors to function efficiently at low frequencies, which directly impacts their capacity to detect distant events from the universe’s past. …”
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Scots Pine Bark Extracts as Co-Hardeners of Epoxy Resins by Tomasz Szmechtyk

“…Extracts from natural waste like bark or leaves are great sources of phytochemicals, which contain functional groups (hydroxyl, carboxylic, vinyl, allyl) attractive in terms of polymer synthesis. …”
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Early Fault-Tolerant Quantum Algorithms in Practice: Application to Ground-State Energy Estimation by Oriel Kiss, Utkarsh Azad, Borja Requena, Alessandro Roggero, David Wakeham, Juan Miguel Arrazola

“…Additionally, we provide quantitative resource estimates, demonstrating a constant factor improvement in the number of samples required to detect a specified change in CDF. …”
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Determination of Technological Features of a Solar Photovoltaic Cell Made of Monocrystalline Silicon P+PNN+ by Cristian-Petre Fluieraru, Gabriel Predușcă, Horia Andrei, Emil Diaconu, Petru Adrian Cotfas, Daniel Tudor Cotfas

“…The development in the field of semiconductor materials and electronic devices has a great impact on systems with renewable energy sources. Determination of the functional parameters of photovoltaic solar cells is essential for the subsequent usage of these semiconductor devices. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…We examined model fit by the posterior mean of the residual deviance and the deviance information criterion to select models. Pairwise MA and NMA were also carried out with a frequentist framework using the R functions ‘netmetabin’ and ‘netmeta’. …”
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PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure. by Marialuisa Pellegrini-Calace, Tim Maiwald, Janet M Thornton

“…Therefore, computational methods which, given a set of 3D coordinates, can automatically identify and describe channels in transmembrane proteins are key tools to provide insights into how they function.Herein we present PoreWalker, a fully automated method, which detects and fully characterises channels in transmembrane proteins from their 3D structures. …”
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Efficacy of angiotensin receptor blockers for erectile dysfunction in hypertensive men: A systematic review by Swati Sucharita Dash, Harshita K Kothari, Shashwati Pankaj, Lakshmi Venkatachalam, Jignesh Bhate, Guruprasad K S Rao

“…A literature search was carried out in Medline, Embase, the Cochrane Library databases, and other relevant sources to select clinical studies that compared the efficacy of ARBs with other antihypertensive drugs in men with concomitant hypertension and ED. …”
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Identification of Keystone Plant Species for Avian Foraging and Nesting in Beijing’s Forest Ecosystems: Implications for Urban Forest Bird Conservation by Lele Lin, Yongjian Zhao, Chao Yuan, Yushu Zhang, Siyu Qiu, Jixin Cao

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BICYCLE TRAFFIC IN THE CITIES by Elżbieta MACIOSZEK, Irena JURDANA

“…This article presents the characteristics of the bicycle infrastructure and services offered in selected cities in the world and Poland, as well as the issues of bicycle counters as sources of data on bicycle traffic volume, along with an exemplary analysis of this type of data.…”
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Phonological and Sociolinguistic Challenges of Translating Yorùbá Play, and Game Songs to Singable English for Children by Bolanle O. Sogunro

“…Consequently, the translations are “unperformable” as oral texts, thus, failing their aesthetic and functional purpose for children. To investigate the translation problems involved and proffer solutions, this essay analyses five randomly selected Yoruba songs and seven of their available English translations from online sources and an unpublished manuscript, using sociolinguistic translation theory and the analytical framework of Franzon’s song translation choices. …”
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Seismic loss analysis of buckling-restrained braced frames considering the effects of modeling uncertainties by A. M. Azimi, E. Khojastehfar

“…The variation of the modulus of elasticity and the yield strength constitute the sources of the uncertainties  for this study. The two-dimensional 4-, 8-, and 12-story frames ,selected from symmetrical three-dimensional structures, were studied. …”
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CRISPR-Cas9 and Its Bioinformatics Tools: A Systematic Review by Alicja Jasieniecka, Inês Domingues

“…This systematic review summarizes the functionality and key features of such tools. Studies published after 2012 were selected through searches in PubMed, Google Scholar, and other sources, with the final search conducted on 9 November 2024. …”
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Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals. by Jacqueline Scholl, Nils Kolling, Natalie Nelissen, Michael Browning, Matthew F S Rushworth, Catherine J Harmer

“…Here, we show that when the effects of a selective serotonin reuptake inhibitor (SSRI, citalopram) are studied over longer timescales, learning is robustly improved. …”
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Use of Naringinase to Modify the Sensory Quality of Foods and Increase the Bioavailability of Flavonoids: A Systematic Review by Joanna Bodakowska-Boczniewicz, Zbigniew Garncarek

“…The use of naringinase for preparing functional beverages with increased antioxidant activity and for preparing steviol sweeteners is also presented. …”
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Detection of VOCs and Biogenic Amines Through Luminescent Zn–Salen Complex-Tethered Pyrenyl Arms by Roberta Puglisi, Caterina Testa, Sara Scuderi, Valentina Greco, Giuseppe Trusso Sfrazzetto, Manuel Petroselli, Andrea Pappalardo

“…Fluorescence titrations and density functional theory (DFT) calculations reveal and explain the high binding affinity of this receptor toward selected amines, demonstrating its potential as an effective tool for amine detection.…”
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Stilpón z Megár medzi sokratikou a helenizmom by Jaroslav Cepko

“… Ancient sources depict the so-called Megarian school in two seemingly contrasting ways: on the one hand, as eristic and dialectic, and on the other, as a continuation of the Socratic ethical orientation in philosophy. …”
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