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Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes
Published 2025-02-01“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
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Understanding Mantle Edge Pigmentation Through Comprehensive Transcriptomic Profiling of the Chilean Oyster (<i>Ostrea chilensis</i>)
Published 2025-01-01“…A total of 935,620,583 paired-end reads were de novo assembled, 50,908 transcripts produced, and a reference transcriptome created with 37.92% GC content and an N50 of 1929 bp. Functional annotation showed a total of 51,315 GO terms, with 21,322 annotations on Biological Process, 14,578 annotations on Molecular Functions, and 15,415 annotations on Cellular Component. …”
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Optimizing maize germination forecasts with random forest and data fusion techniques
Published 2024-11-01“…Traditional methods for detecting seed germination rates often involve lengthy experiments that result in damaged seeds. …”
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Strategies and Challenges for Unmanned Aerial Vehicle-Based Continuous Inspection and Predictive Maintenance of Solar Modules
Published 2024-01-01“…Our review paper emphasizes instant functionality and practical insights for predictive maintenance, without necessitating complex computing resources or optimization tools. …”
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Evaluation of innovative technology market potential on the basis of technology audit
Published 2019-05-01“…This mechanism is built on structure evaluation table of technology market potential level detection as an object of commercialization. To ensure the efficiency of practical effect of the mechanism proposed, the authors systematized and completed methods of functional analysis and scanning of market environment for the purpose of qualitative comprehensive evaluation and innovative technology market potential forecasting.Introduction of the proposed evaluation method for technology market potential will result in the improvement of efficiency of enterprise innovation activity due to more rational distribution of available resources and immediate financing of developments with greater market potential.…”
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Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics
Published 2025-06-01“…In this work, miRNA-21 was selectively detected using a complementary DNA probe modified with methylene blue, as a redox mediator, immobilized onto an AuNPs-functionalized, paper-based screen-printed electrode. …”
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An atypical presentation of autoimmune hepatitis with delayed menarche in a Nigerian adolescent: a case report
Published 2025-01-01“…It emphasizes the need for increased awareness and better diagnostic resources to improve early detection and management of autoimmune hepatitis in sub-Saharan Africa. …”
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Advances in Wearable Biosensors for Wound Healing and Infection Monitoring
Published 2025-02-01“…Wound healing is a complicated biological process that is important for restoring tissue integrity and function after injury. Infection, usually due to bacterial colonization, significantly complicates this process by hindering the course of healing and enhancing the chances of systemic complications. …”
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Epidemiology of amyotrophic lateral sclerosis in the Krasnoyarsk region
Published 2024-01-01“…The increase in the incidence and detection of ALS emphasizes the need to develop new approaches to the treatment and rehabilitation of patients with ALS.…”
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HIV-associated neurocognitive disorders in Africa: challenges, peculiarities, and future directions
Published 2024-11-01“…Enhancing awareness, education, and capacity- building initiatives can improve early detection and management of neurocognitive disorders among individuals living with HIV. …”
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Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours
Published 2025-06-01“…Primary aldosteronism is the most common endocrine cause of hypertension, affecting 5–10% of hypertensive patients. Determining the source of aldosteronism is necessary for correct diagnosis and further molecular analysis. …”
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Mid-infrared Ensemble Variability of Broad-line and Narrow-line Seyfert 1 Galaxies
Published 2025-01-01“…The MIR variability of the combined sample is positively correlated with black hole mass and the FWHM of the H β emission line at long rest-frame time lags. (4) The long-term MIR variability of the combined sample may be mainly driven by the Eddington ratio. (5) For BLSy1 galaxies, the MIR variability of radio-detected sources is greater than that of radio-undetected sources, whereas for NLSy1 galaxies, the opposite is true.…”
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Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers
Published 2025-01-01“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
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Influence of Organic Nitrogen Derived from Recycled Wine Lees and Inorganic Nitrogen on the Chemical Composition of Cabernet Sauvignon Wines Fermented in the Presence of Non-Saccha...
Published 2024-12-01“…In this study, the influences of inorganic nitrogen source (INS) and organic nitrogen source (ONS) supplementation during the wine fermentation process using three non-Saccharomyces yeasts (<i>Candida zemplinina</i>, <i>Candida oleophila</i>, and <i>Candida boidinii</i>) were analyzed. …”
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