Lightweight deep learning system for automated bone age assessment in Chinese children: enhancing clinical efficiency and diagnostic accuracy by Pang Hai, Zhang Bin, Liu Kesheng, Li Cong, Xu Fei

“…In the first stage, the YOLOv8 algorithm precisely localizes 13 key epiphyses in hand radiographs, achieving a mean Average Precision (mAP) of 99.5% at Intersection over Union (IoU) = 0.5 and 94.0% within IoU 0.5–0.95, demonstrating robust detection performance. The second stage employs a modified EfficientNetB3 architecture for fine-grained epiphyseal grade classification, enhanced by the Rectified Adam (RAdam) optimizer and a composite loss function combining center loss and weighted cross-entropy to mitigate class imbalance. …”
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Biodegradation of Phenanthrene by <i>Mycobacterium</i> sp. TJFP1: Genetic Basis and Environmental Validation by Shuyun Li, Jiazhen Liu, Ping Fang

“…This study provides efficient strain resources for the bioremediation of PAH contamination.…”
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Platinum-Induced Ototoxicity in Pediatric Cancer Patients: A Comprehensive Approach to Monitoring Strategies, Management Interventions, and Future Directions by Antonio Ruggiero, Alberto Romano, Palma Maurizi, Dario Talloa, Fernando Fuccillo, Stefano Mastrangelo, Giorgio Attinà

“…This approach addresses critical gaps in current practice while acknowledging resource limitations across diverse healthcare environments.…”
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The high-quality telomere-to-telomere genome assembly of the earthworm (Amynthas aspergillum) by Guangquan Peng, Yanghe Qin, Zhiming Yan, Mingwei He, Yucheng Zhao, Neng Jiang, Changhong Wei

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EZSCAN for undiagnosed type 2 diabetes mellitus: A systematic review and meta-analysis. by Antonio Bernabe-Ortiz, Andrea Ruiz-Alejos, J Jaime Miranda, Rohini Mathur, Pablo Perel, Liam Smeeth

“…<h4>Objectives</h4>The EZSCAN is a non-invasive device that, by evaluating sweat gland function, may detect subjects with type 2 diabetes mellitus (T2DM). …”
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RDSM: Underwater multi-AUV relay deployment and selection mechanism in 3D space by Yafei Liu, Na Liu, Hao Li, Yi Jiang, Junwu zhu

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Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases by András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi

“…We used a structurally consistent model on kinase‐docking motif interactions to facilitate the discovery of short functional sites in the structurally flexible and functionally under‐explored part of the human proteome and applied experimental tools specifically tailored to detect low‐affinity protein–protein interactions for their validation in vitro and in cell‐based assays. …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…Fatty acids, among other substrates, are utilized by immune cells as an energy source. Therefore, L-carnitine, which is authorized as a feed additive in cattle, may influence the metabolism of peripheral blood mononuclear cells (PBMC) during an immune challenge. …”
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Double-transmitting and Sextuple-receiving Borehole Transient Electromagnetic Method and Experimental Study by Bo Wang, Shengdong Liu, Shining Li, Fubao Zhou

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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

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A long-term reconstruction of a global photosynthesis proxy over 1982–2023 by Jianing Fang, Xu Lian, Youngryel Ryu, Sungchan Jeong, Chongya Jiang, Pierre Gentine

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The effect of PLGA-PEG-PLGA modification on the sol-gel transition and degradation properties by J. Oborna, L. Mravcova, L. Michlovska, L. Vojtova, M. Vavrova

“…Itaconic acid, obtained from renewable resources, delivers a reactive double bond and carboxylic functional group to the end of PLGA-PEG-PLGA copolymer: this is important for a reaction with biologically active substances. …”
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Differences in Intestinal Microbiota Between White and Common Cranes in the Yellow River Delta During Winter by Xiaodong Gao, Yunpeng Liu, Zhicheng Yao, Yuelong Chen, Lei Li, Shuai Shang

“…During the winter, when food resources are scarce, studying their gut microbiota can effectively reveal the feeding patterns of these two crane species, thereby providing valuable data for crane conservation efforts. …”
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Discovery of Genomic Targets and Therapeutic Candidates for Liver Cancer Using Single-Cell RNA Sequencing and Molecular Docking by Biplab Biswas, Masahiro Sugimoto, Md. Aminul Hoque

“…This study aims to uncover key genomic features, analyze their functional roles, and propose potential therapeutic drugs identified through molecular docking, utilizing single-cell RNA sequencing (scRNA-seq) data from liver cancer studies. …”
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Ethics of Sensor-Based Surveillance of People with Dementia in Clinical Practice by Jacob Lahr, Nicole Schulze, Larissa N. Wüst, Claus Beisbart, Lena C. Bruhin, Marcello Ienca, Tobias Nef, Manuel Trachsel, Stefan Klöppel

“…The level of privacy intrusion to detect occurring falls varies widely between different sensor systems. …”
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Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins by Ruolan Yi, Jiaoyang Zheng, Zhichao Xu, Jiayan Wu, Fangfang Liu, Jinxin Zheng, Duoyun Li, Shiqing Han, Zhijian Yu

“…Additionally, while the growth adaptation of K2044−8Xyl−60G under xylose pressure was confirmed, no amino acid mutations were detected in the functional proteins of this xylose-induced isolate, suggesting that persistent xylose pressure does not cause nonsense mutations in the bacterial genome. …”
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Profiling the diversity of the village chicken faecal microbiota using 16S rRNA gene and metagenomic sequencing data to reveal patterns of gut microbiome signatures by Mxolisi Nene, Mxolisi Nene, Nokuthula Winfred Kunene, Rian Pierneef, Rian Pierneef, Rian Pierneef, Khanyisile Hadebe

“…ARGs were identified, with MarA, PmrF, and AcrE detected in KwaZulu-Natal, and cpxA, mdtG, and TolA in Limpopo. …”
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Effects of enhanced fermentation with high-yielding strains of Tetramethylpyrazine on flavor quality of Douchiba by Panpan Yang, Qin Wang, Yurou Yang, Anyan Wen, Haiying Zeng, Na Liu, Likang Qin

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A Novel Approach to Cognitive Load Measurement in N-Back Tasks Using Wearable Sensors, Empirical Mode Decomposition With Machine Learning, and Explainable AI for Feature Importance by Aakanksha Dayal, Ziaullah Khan, Kiramat Ullah, Hee-Cheol Kim

“…This study introduces a novel approach for detecting mental workload and stress, utilizing ECG and Fingertip-PPG data from the MAUS dataset. …”
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Proteomic analysis of plasma unravels dynamic pathways and potential biomarkers indicating disease stages following Mtb infection by Zonglei Zhou, Jie Tian, Yuying He, Haiyan Xiong, Weibing Wang

“…ABSTRACT Tuberculosis (TB) stages depend greatly on the interaction between Mycobacterium tuberculosis (Mtb) and the host response. As a non-negligible source of active tuberculosis (ATB), individuals with latent Mtb infection (LTBI) are insidious and hard to be detected due to limited biomarkers. …”
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