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2481
Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes
Published 2025-02-01“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
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2482
Software Implementation of the Epps-Pulley Criterion in Matlab Modeling Environment
Published 2024-05-01“…We used an approximation by a beta function of the third kind for a sample of over 1000 elements.Results. …”
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2483
In situ, modeled, and earth observation monitoring of surface water availability in West African rangelands
Published 2025-06-01“…The 12 locations can function as sentinel ponds to monitor local water availability. …”
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2484
Feeding black soldier fly (Hermetia illucens) larvae with mushrooms and then exposing them to UVB produces larvae extremely rich in vitamins D2 and D3
Published 2025-12-01“…Black soldier fly larvae (BSFL) are a sustainable source of protein for feed but they can also be a sustainable source of some phytochemicals due to their ability to bioaccumulate them. …”
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2485
Protective role of extracellular vesicles against oxidative DNA damage
Published 2025-03-01“…Abstract Background Oxidative stress, a source of genotoxic damage, is often the underlying mechanism in many functional cell disorders. …”
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2486
Extracting Realistic Pedestrian, Cycling, and Driving Street Networks from OpenStreetMap
Published 2025-07-01“…An algorithm was designed to detect these cases based on the geometry of the street segments. …”
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2487
Exploration of Predicted Nitrogen-Containing Natural Products from Northern Canadian Bark Beetle-Associated Bacteria
Published 2025-03-01“…Nitrogen-15 NMR spectroscopy was employed to detect nitrogen-containing functional groups in crude extracts, revealing distinct signals for amides, amines, and nitrogen heterocycles. …”
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2488
IDENTIFICATION OF ELECTROMAGNETIC ULTRA LOW FREQUENCY (ULF) SIGNAL ANOMALIES AS PRECURSORS OF A MAGNITUDE 5 EARTHQUAKE IN THE SULAWESI REGION
Published 2024-05-01“…The anomaly source azimuth direction was also determined.…”
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2489
Regional and strain-level prevalence of nitrogen-fixing Bradyrhizobium with potential N2O reduction in South Korea
Published 2025-06-01“…Abstract Agricultural practices are the largest anthropogenic source of nitrous oxide (N2O), a potent greenhouse gas contributing to global climate change. …”
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2490
Repair-mediated duplication by capture of proximal chromosomal DNA has shaped vertebrate genome evolution.
Published 2009-05-01“…These events are thought to be a source of genomic instability and human diseases, but it is unclear whether they have contributed significantly to genome evolution. …”
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2491
Devicology: Expanding fieldwork possibilities for architectural observations in inhabited interiors
Published 2022-04-01“…These visually chaotic yet surprisingly functional structures are the only tool of the current dwellers to negotiate with the restricting standard apartment plans that were originally designed for a very different sector of the Japanese population. …”
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2492
The Role of High-mass Stellar Binaries in the Formation of High-mass Black Holes in Dense Star Clusters
Published 2025-01-01“…We study the differences in the demographics of BH–BH mergers and their implications for LIGO–Virgo–Kagra detections as a function of ${f}_{{\rm{b}},15}^{{\prime} }$ .…”
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2493
Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis
Published 2024-12-01“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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2494
Genome Mining of Terpene Synthases from Fourteen <i>Streptomyces</i> Strains
Published 2025-06-01“…A total of forty-eight TPSs were identified and categorized through phylogenetic analysis, and five representative TPSs distantly related to known TPSs were selected for functional investigation. Biochemical assays revealed that TAC28_6116 is a sesquiterpene synthase producing thujopsan-2β-ol (<b>1</b>) and thujopsene (<b>2</b>), marking the first report of thujopsan-2β-ol production from a bacterial source. …”
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2495
Evaluation of Cloud Masking Methods using Sentinel-2 Satellite Images on Google Earth Engine: A Case Study in Vietnam
Published 2024-09-01“…These include the Fmask (Function of mask) method, the Fmask CDI (Cloud Displacement Index) method, and the Fmask CSP (Cloud Score Plus) method. …”
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2496
Biomimetic Hydrodynamic Sensor with Whisker Array Architecture and Multidirectional Perception Ability
Published 2024-10-01“…The whisker sensor is capable of detecting a variety of hydrodynamic information, including the velocity (RMSE < 0.061 m s−1) and direction of the steady flow field, the frequency (error < 0.05 Hz) of the dynamic vortex wake, and the orientation (error < 7°) of the vortex wake source, demonstrating its extensive potential for underwater environmental perception and communication, especially in deep sea conditions.…”
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2497
Joint Survey Processing. III. Compact Oddballs in the COSMOS Field—Little Red Dots and Transients
Published 2025-01-01“…We draw the upper limit of the AGN luminosity function Φ = 1.1 × 10 ^−7 Mpc ^3 mag ^−1 for M _UV = −21 at redshift of 6. …”
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2498
Multiwavelength Variability Analysis of the Blazar PKS 0727-11: An ~ 168 day Quasiperiodic Oscillation in the γ-Ray
Published 2025-01-01“…It is the first time that periodic variations have been detected in this source, and further supported by other methods: weighted wavelet z -transform, phase dispersion minimization, REDFIT, autoregressive integrated moving average model, and structure function analysis. …”
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2499
Current status of transcriptome sequencing technology in ruminants
Published 2025-06-01“…During the lactation stage of ruminants, transcriptome sequencing is used to screen for differentially expressed genes in blood tissue, which can identify candidate functional genes for milk production traits. Transcriptome sequencing can detect genes with low expression levels, identify new gene transcripts and alternative splicing events, detect and analyze the biological regulatory mechanisms of the body, reveal differences in gene expression levels during breeding, and reveal the interaction between hosts and pathogens. …”
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2500
INTERNATIONAL TECHNICAL AID IN POST-CONFLICT RECOVERY: LESSONS FROM GLOBAL PRACTICES FOR DE-OCCUPIED AREAS
Published 2025-07-01“…ITA is conceptualized as a strategic resource that encompasses financial, technical, expert, and institutional support from international donors aimed at the implementation of long-term sustainable development programs. …”
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