Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer by Xiangru Zheng, Wenjun Li, Xiaoli Li, Qianyi Yao, Luquan Zheng, Rongrong Fan, Ping Bie

“…Bioinformatics analysis was conducted to explore the function of GJB4 in PC cells. Changes in ferroptosis in PC cells following GJB4 downregulation were detected by immunofluorescence staining, transmission electron microscopy, and western blotting.ResultsGJB4 expression was found to be upregulated in PC tissues and positively correlated with patient survival. …”
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Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

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Gene Network Biological Validity Based on Gene-Gene Interaction Relevance by Francisco Gómez-Vela, Norberto Díaz-Díaz

“…Finally, the ability of GeneNetVal to detect biological functionality of the network is shown.…”
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REVISITING THE ORGANIZATION OF A CLINICAL (MEDICAL) PSYCHOLOGIST WORK AT THE FIRST STAGE OF MEDICAL REHABILITATION IN THE CONDITIONS OF THE INTENSIVE CARE UNIT (ICU) BY THE EXAMPLE... by Алена Валентиновна Слекишина, Марина Григорьевна Жестикова, Светлана Станиславовна Зиборова

“…There is currently a pressing need to devise a way of neurophycological diagnostics of higher mental functions which would allow to detect cognitive impairment in patients in the ICU during the first stages of medical rehabilitation taking into account working hours constraints.…”
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Advanced Suspension Techniques in Interferometric Gravitational Wave Detectors: An Overview by Vishnu G. Nair

“…This isolation is crucial for enabling the detectors to function efficiently at low frequencies, which directly impacts their capacity to detect distant events from the universe’s past. …”
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Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“…Due to their insidious onset and impact on critical functional areas of the brain, these tumors often result in irreversible abnormalities in growth and development, as well as cognitive and motor impairments in affected children. …”
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Visible Triple-Wavelength Switchable Emission Generated in Passively Q-Switched Nd:YVO₄ Self-Raman Laser by Songtao Li, Shengxi Zheng, Bowen Zheng, Yong Wei, Yongchang Zhang, Yanmin Duan, Haiyong Zhu

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In Situ Analysis of Jupiter's Broadband Kilometric Auroral Radio Emissions With Juno by B. Collet, L. Lamy, C. K. Louis, V. Hue, T. K. Kim

“…Taking advantage of Juno in situ measurements within the auroral regions, we surveyed the Juno/Waves radio observations over the 60 first orbits to identify 7 bKOM source candidates. These were mostly detected during dawn storm auroral episodes (4/7) and three were found to be colocated with auroral cavities. …”
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Green Recovery and Identification of Antioxidant and Enzyme Inhibitor Molecules from Pisco Grape Pomace by Targeted Effects Analysis Using Thin-Layer Chromatography, Bioassay, and... by Jacqueline Poblete, Joaquín Fernández-Martínez, Mario Aranda, Issis Quispe-Fuentes

“…Bioactive molecules were detected and identified applying directed effect analysis on planar chromatography coupled to mass spectrometry. …”
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Multiwavelength Constraints on the Local Black Hole Occupation Fraction by Colin J. Burke, Priyamvada Natarajan, Vivienne F. Baldassare, Marla Geha

“…We also constrain the extremely low-luminosity end ( L _bol ≲ 10 ^40 erg s ^−1 ) of the active galactic nucleus (AGN) luminosity functions at z = 0. Our AGN luminosity functions are broadly consistent with an extrapolation of the shallow slope of the AGN luminosity functions from previous work.…”
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A quantum inspired machine learning approach for multimodal Parkinson’s disease screening by Diya Vatsavai, Anya Iyer, Ashwin A. Nair

“…As disease progression impairs speech, memory, and motor functions over time, early diagnosis is crucial for preserving patients’ quality of life. …”
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Carbon-Based Nanoadsorbents for the Removal of Emerging Pollutants by M. Venkata Ratnam, P. Akilamudhan, K. Senthil Kumar, S. Narasimha Reddy, K. Nagamalleswara Rao, Feroz Shaik, D. M. Reddy Prasad

“…Emerging contaminants (ECs) are substances that have been detected in water but have not been thoroughly tested or regulated. …”
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Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis by Jingjing Wei, Yuan Tian, Meiqi Guan, Jinshu Wei, Yong Ji, Guozhong Tao, Karl G. Sylvester

“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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Urinary Exosomes by Irena Dimov, Ljubinka Jankovic Velickovic, Vladisav Stefanovic

“…Thus, UE have valuable potential as a source of biomarkers for early detection of various types of diseases, monitoring the disease evolution and/or response to therapy. …”
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An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies by Chenfang Miao, Menghan Zhang, Ying Zheng, Xiaoyan Lin, Shuangying Yang, Linlin Xu, Sitong Lu, Zhengjun Huang, Jianyong Huang, Yanjie Zheng, Shaohuang Weng

“…However, efficient and sensitive detection methods remain limited. In this study, high quantum yield carbon dots (CA/EDA-CDs) were synthesized via a hydrothermal method using riboflavin as the carbon source, citric acid and ethylenediamine as functionalizing agents and dopants. …”
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Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons by Kishoree K. Kumaree, James M. Brimson, Kanika Verma, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab

“…Abstract Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. …”
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Multimodal imaging of dark without pressure in high myopia reveals evidence that photoreceptor microscopic lesions may be reversible by Qingge Guo, Xiuxiu Jin, Xiaoyu Xin, Xiaohong Guo, Shuai Ming, Yuxiang Li, Bo Lei

“…Previous studies have concluded that DWP alone has no impact visual acuity, visual field, or other visual functions. This study aims to reveal the multimodal imaging manifestations of DWP in high myopia and to explore its impact on retinal function. …”
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Design and Development of an EMG Upper Limb Controlled Prosthesis: A Preliminary Approach by Ricardo Rodrigues, Daniel Miranda, Vitor Carvalho, Demétrio Matos

“…Preliminary results demonstrate reliable detection of muscle contractions (threshold = 7 ADC units, ~34 mV) and motor actuation with a response time of ~150 ms, offering a cost-effective alternative to commercial systems. …”
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Growth and Form Trait Variation Analysis Among Different Clones of Michelia chapensis by Zhixi DENG, Baishuan LYU, Rong HUANG, Limin ZHOU, Runhui WANG, Li CHEN, Zhijun LAI, Jiaqi CHEN, Jie ZHU, Ruping WEI, Huiquan ZHENG

“…Significant (P < 0.05) to highly significant (P < 0.01) phenotypic and genetic correlations were detected among the traits (except between tree height and crown-to-diameter ratio). …”
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PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure. by Marialuisa Pellegrini-Calace, Tim Maiwald, Janet M Thornton

“…Therefore, computational methods which, given a set of 3D coordinates, can automatically identify and describe channels in transmembrane proteins are key tools to provide insights into how they function.Herein we present PoreWalker, a fully automated method, which detects and fully characterises channels in transmembrane proteins from their 3D structures. …”
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