Near telomere-to-telomere genome assembly of the blackspot tuskfish (Choerodon schoenleinii) by Zhongdian Dong, Jiahao Gao, Yanfei Zhao, Jin Gao, Yusong Guo, Zhongduo Wang, Ning Zhang

“…Notably, telomeres were identified at both ends of 23 chromosomes, with 14 being completely gapless and only 12 gaps detected across the remaining nine. A total of 24,524 protein-coding genes were annotated, with 96.25% assigned functional annotations. …”
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Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics by Salvatore Benfatto, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling, David Capper, Volker Hovestadt

“…Here, we describe an interpretable framework to explain the classifier’s decisions. We show that functional genomic regions of various sizes are predominantly employed to distinguish between different tumor classes, ranging from enhancers and CpG islands to large-scale heterochromatic domains. …”
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Accumulation and effect of contaminants in soil biota following waste stream application in agriculture: A European perspective by Iris L. Schaap, Marjolein Derks, Peter W.G. Groot Koerkamp, Nico W. van den Brink

“…In particular, behavioural changes in soil organisms, which significantly influence soil functionality and ecosystem processes, remain underexplored. …”
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Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. by Dave T Gerrard, Claudia Fricke, Dominic A Edward, Dylan R Edwards, Tracey Chapman

“…However, the subtle nature of those effects suggests substantial functional redundancy or parallelism in this gene network, which could buffer females against excessive responses. …”
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Diversity and composition of sponge-associated microbiomes from Korean sponges revealed by full-length 16S rRNA analysis by Myoung-Sook Shin, Inho Yang, Weihong Wang, Hiyoung Kim

“…Our integrative, high-resolution approach not only uncovers remarkable taxonomic and functional diversity, but also provides a valuable genetic resource for future marine natural-product discovery and advances ecological restoration efforts.…”
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The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
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Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants. by Dai-Yin Chao, Yi Chen, Jiugeng Chen, Shulin Shi, Ziru Chen, Chengcheng Wang, John M Danku, Fang-Jie Zhao, David E Salt

“…Complementation verified the identity of HAC1, and expression in Escherichia coli lacking a functional arsenate reductase confirmed the arsenate reductase activity of HAC1. …”
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A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
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The Role of Circulating Biomarkers in Patients with Coronary Microvascular Disease by Rossella Quarta, Giovanni Martino, Letizia Rosa Romano, Giovanni Lopes, Francesco Fabio Greco, Carmen Anna Maria Spaccarotella, Ciro Indolfi, Antonio Curcio, Alberto Polimeni

“…Coronary microvascular disease (CMD) comprises a spectrum of conditions characterized by the functional and structural abnormalities of coronary microcirculation, affecting vessels typically smaller than 500 μm. …”
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An Affordable AI-Driven and 3D-Printed Personalized Myoelectric Prosthesis: Design, Development, and Assessment by Enzo Romero, Jose G. Garcia, Magno Parra, Sebastian Caballa, Alejandro M. Saldarriaga, Edson F. Luque, Dante J. Rodriguez, Victoria E. Abarca, Dante A. Elias

“…Conventional myoelectric prostheses, while offering functional restoration, have limited adaptability and high cost. …”
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Discovery of a new subgroup of sulfur dioxygenases and characterization of sulfur dioxygenases in the sulfur metabolic network of Acidithiobacillus caldus. by Wei Wu, Xin Pang, Jianqiang Lin, Xiangmei Liu, Rui Wang, Jianqun Lin, Linxu Chen

“…We cloned and expressed these genes, and detected the SDO activity of recombinant protein A5904_0421 by a GSH-dependent in vitro assay. …”
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Melatonin: A Novel Indolamine in Oral Health and Disease by V. K. Chava, K. Sirisha

“…Recent studies, by Claustrat et al. (2005), detected few extrapineal sources of melatonin like retina, gastrointestinal tract, and salivary glands. …”
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Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. by Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw

“…Sixty percent of the piglets were transgenic, with mutant GUCY2D mRNA detected in the retina of all animals tested. Functional impairment of vision was observed among the transgenic pigs at 3 months of age, with a follow-up at 1 year indicating a subsequent slower progression of phenotype. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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The barley genome sequence assembly reveals three additional members of the CslF (1,3;1,4)-β-glucan synthase gene family. by Miriam Schreiber, Frank Wright, Katrin MacKenzie, Pete E Hedley, Julian G Schwerdt, Alan Little, Rachel A Burton, Geoffrey B Fincher, David Marshall, Robbie Waugh, Claire Halpin

“…This significant divergence within the gene family might be related to multiple functions of (1,3;1,4)-β-glucans in the Poaceae. Emerging genomic and global expression data for barley and other cereals is a powerful resource for characterising the evolution and dynamics of complete gene families. …”
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Morpho-Molecular and Genomic Characterization of <i>Penicillium mexicanum</i> Isolates Retrieved from a Forsaken Gold Mine by João Trovão, Fabiana Soares, Diana Sofia Paiva, António Portugal

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord by Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhang

“…Glial cells play crucial roles in regulating physiological and pathological functions, including sensation, the response to infection and acute injury, and chronic neurodegenerative disorders. …”
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IT GOVERNANCE IN THE BANKING SECTOR: EVIDENCE FROM ITALY, GERMANY, FRANCE AND SPAIN by Ida Claudia Panetta, Sabrina Leo, Fabrizio Santoboni, Gianfranco Vento

“…IT is an intrinsic component of banks’ operational functioning; it is a key resource in developing and supporting banking services, enabling institutions’ strategies, and it is essential for almost all banking processes and distribution channels. …”
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Impact of short-term aircraft noise on cardiovascular disease risk in the area surrounding London Heathrow airport: the RISTANCO epidemiological study by Xiangpu Gong, Nicole Itzkowitz, Calvin Jephcote, Kathryn Adams, Glory O Atilola, John Gulliver, Marta Blangiardo, Anna Hansell

“…Are there interactions with factors such as age, gender, ethnicity and deprivation that may function as effect modifiers? Is there variability in risk estimates between areas with consistent patterns of noise exposure versus those with changing patterns of noise exposure? …”
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Multi-Locus GWAS Mapping and Candidate Gene Analysis of Anticancer Peptide Lunasin in Soybean (<i>Glycine max</i> L. Merr.) by Rikki Locklear, Jennifer Kusumah, Layla Rashad, Felecia Lugaro, Sonia Viera, Nathan Kipyego, Faith Kipkosgei, Daisy Jerop, Shirley Jacquet, My Abdelmajid Kassem, Jiazheng Yuan, Elvira de Mejia, Rouf Mian

“…Our study is an important effort to understand the genetic basis and functional genes for lunasin production in soybean seeds.…”
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