Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Secondary outcomes included: unplanned 60- and 90-day hospital re-admissions; quality of transition; health-related quality of life (EuroQol-5 Dimensions, five-level version); and self-reported healthcare resource use. Data sources National Health Service Secondary Use Services data and Hospital Episodes data for work package 2 and routinely recorded National Health Service acute trust hospital data on re-admissions for work packages 5 and 6. …”
Get full text

An openEHR based infection control system to support monitoring of nosocomial bacterial clusters and contacts by Pascal Biermann, Claas Baier, Ann Christin Vietor, Benedikt Zacher, Tom Baumgartl, Tatiana von Landesberger, Michael Behnke, Michael Storck, Markus Petzold, Martin Kaase, HiGHmed lnfection Control Study Group, Dirk Schlüter, Michael Marschollek, Simone Scheithauer, Antje Wulff

“…Digital, routine data-driven solutions are promising, but often proprietary, non-interoperable, or limited in functional scope. The open-source Smart Infection Control System (SmICS) offers automatic calculations and interactive views on patients' movement and lab data, epidemic curves, contact networks, complemented by temporal-spatial visualizations. …”
Get full text

A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
Get full text

HBXIP suppression reduces cell proliferation and migration and its overexpression predicts poor prognosis in non-small-cell lung cancer by Yixuan Wang, Nan Li, Shuanlong Che, Tiefeng Jin, Junjie Piao, Shuangping Liu, Zhenhua Lin

Get full text

A Neural Device Inspired by Neuronal Oscillatory Activity with Intrinsic Perception and Decision‐Making by Congtian Gu, Guoliang Ma, Mengze Zhang, Hu Shen, Liaoyuan Pu, Yanhe Song, Shilong Yan, Dakai Wang, Kaixian Ba, Bin Yu, Zhiwu Han, Luquan Ren

“…The device utilizes alternating signals generated by coupling the human body with the power‐frequency electromagnetic field as both a signal source and energy source, mimicking neuronal oscillatory activity. …”
Get full text

Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…The target bacterial isolate was detected in medfly when inoculated with liquid diet regardless of age, but those fed a slurry-based diet and a separate water source had less establishment. …”
Get full text

Diverse ancestral representation improves genetic intolerance metrics by Alexander L. Han, Chloe F. Sands, Dorota Matelska, Jessica C. Butts, Vida Ravanmehr, Fengyuan Hu, Esmeralda Villavicencio Gonzalez, Nicholas Katsanis, Carlos D. Bustamante, Quanli Wang, Slavé Petrovski, Dimitrios Vitsios, Ryan S. Dhindsa

“…These findings highlight the need for enhanced population representation in genomic resources to fully realize the potential of precision medicine and drug discovery. …”
Get full text

Comprehensive Phenotypic Characterization and Genomic Analysis Unveil the Probiotic Potential of <i>Bacillus velezensis</i> K12 by Yingying Tang, Tian Li, Yihong Huang, Liangliang Wu, Xiaobo Liu, Ruichao Yue, Jianmin Yuan

“…The complete genome sequencing of <i>B. velezensis</i> K12 revealed a genomic length of 3,973,105 base pairs containing 4123 coding genes, among which 3973 genes were functionally annotated. The genomic analysis identified genes associated with acid and bile tolerance, adhesion, antioxidants, and secondary metabolite production, whereas no functional genes related to enterotoxins or transferable antibiotic resistance were detected, thereby confirming the probiotic properties of <i>B. velezensis</i> K12. …”
Get full text

Subclinical Aortic Root Pathology in Close Relatives of Patients with Bicuspid Aortic Valve by Ivaniv Y., Lozynska N., Ivaniv I.

“…According to various sources, among the relatives of the first degree (FDR) of affinity the prevalence of BAV is 9.0-21.0%. …”
Get full text

Establishment and characterization of liver‐specific Apoa4‐Cre and Cyp2c11‐Cre rat models in juvenile and adult stages by Wei Dong, Xiang Gao, Feifei Guan, Jirong Pan, Wei Chen, Li Zhang, Lianfeng Zhang

“…The use of floxed rat resource has rapidly increased, but the liver‐specific Cre rat lines for studying liver diseases and interested genes are limited, especially in a spatially and temporally restricted manner. …”
Get full text

DistB-Condo: Distributed Blockchain-Based IoT-SDN Model for Smart Condominium by Anichur Rahman, Md. Jahidul Islam, Ziaur Rahman, Md. Mahfuz Reza, Adnan Anwar, M. A. Parvez Mahmud, Mostofa Kamal Nasir, Rafidah Md. Noor

“…Condominium network refers to intra-organization networks, where smart buildings or apartments are connected and share resources over the network. Secured communication platform or channel has been highlighted as a key requirement for a reliable condominium which can be ensured by the utilization of the advanced techniques and platforms like Software-Defined Network (SDN), Network Function Virtualization (NFV) and Blockchain (BC). …”
Get full text

Composition of the culturable bacterial community associated with the water column and soft tissues from oysters of the mangrove ecosystem at Honda Swamp, Colombian Caribbean by Lersy López Gutiérrez, Martha Torres, Esteban Zarza González, Alejandro Henao Castro, Laura Contreras Vega

“…Microbiological activity is the basis of ecosystems functioning, among these are the mangroves, which offer a wide variety of goods and services to humanity. …”
Get full text

JASBO: Jaya Average Subtraction Based Optimization with Deep Learning Model for Multi-Classification of Infectious Disease from Unstructured Data by Vian Sabeeh, Ahmed Bahaaulddin A. Alwahhab, Ali Abdulmunim Ibrahim Al-kharaz

“…Medical documents are considered an essential source for modern, invented, and robust analysis methods for accurate infection diagnoses. …”
Get full text

Biodegradation of S-Triazine Herbicides Under Saline Conditions by <i>Paenarthrobacter ureafaciens</i> PC, a New Halotolerant Bacterial Isolate: Insights into Both the Degradative... by Chunqing Fu, Yifan Jiang, Bingwen Xu, Xinmei Fu, Liang Tan, Mei Jin

“…Furthermore, the biodegradation pathways of prometryne (the target compound) by this strain were proposed based on the detection of possible degradation intermediates and genome sequencing analysis. …”
Get full text

Unraveling Fish Community Diversity and Structure in the Yellow Sea: Evidence from Environmental DNA Metabarcoding and Bottom Trawling by Jinyong Zhang, Xiaoyu Cui, Lin Lin, Yuan Liu, Jinqing Ye, Weiyue Zhang, Hongjun Li

Get full text

Treatment outcomes and associated factors of stroke in Ethiopia: a systematic review and meta-analysis by Addisu Getie, Shirin Jahan Mumu, Amit Arora

“…Subgroup analysis, meta-regression, and sensitivity analysis were computed to investigate the source of heterogeneity. A log odds ratio was employed to ascertain the association between poor (stroke patients who died or were discharged with significant functional and structural dysfunction) stroke treatment outcomes and associated factors. …”
Get full text

Personality and Personality Disorders in Medication-Overuse Headache: A Controlled Study by SWAP-200 by Federica Galli, Annalisa Tanzilli, Alessandra Simonelli, Cristina Tassorelli, Grazia Sances, Micol Parolin, Patrizia Cristofalo, Ivan Gualco, Vittorio Lingiardi

“…At levels of specific PDs, MOH patients showed higher obsessive and dysphoric traits and better overall psychological functioning than SUD and PD patients. Conclusion. Although MOH, SUD, and PD populations have been evaluated in multiple sites with different levels of expertise, the study supported the presence of a specific constellation of personality in MOH patients including obsessive (perfectionist) and dysphoric characteristics, as well as good enough psychological resources. …”
Get full text

Mitigating malicious denial of wallet attack using attribute reduction with deep learning approach for serverless computing on next generation applications by Amal K. Alkhalifa, Mohammed Aljebreen, Rakan Alanazi, Nazir Ahmad, Sultan Alahmari, Othman Alrusaini, Ali Alqazzaz, Hassan Alkhiri

“…Abstract Denial of Wallet (DoW) attacks are one kind of cyberattack whose goal is to develop and expand the financial sources of a group by causing extreme costs in their serverless computing or cloud environments. …”
Get full text

Association of Trace Elements with Polycystic Ovary Syndrome in Women—A Case-Control Study by Tinkara Srnovršnik, Bojana Pinter, Milena Horvat, Janja Snoj Tratnik, Ingrid Falnoga, Darja Mazej, Ivan Verdenik, Irma Virant-Klun

“…<b>Results:</b> In women with PCOS, lower Mo levels in whole blood (<i>p</i> = 0.024) and serum (<i>p</i> = 0.011) and higher serum Cu levels (<i>p</i> = 0.026) were detected when compared to healthy controls. Results of this study show that amendments in Cu and Mo levels might be related to altered kidney and liver function and disrupted hormonal balance in PCOS women. …”
Get full text

AN INFLUENCE OF SPONTANEOUS MICROFLORA OF FERMENTED HORSEMEAT PRODUCTS ON THE FORMATION OF BIOLOGICALLY ACTIVE PEPTIDES by I. M. Chernukha, I. N. Nikonov, N. G. Mashentseva, D. L. Klabukova, D. A. Afanasev, L. I. Kovalyov, L. А. Ilina

“…Therefore, in the studied product, good preservation of the main spectra of muscle proteins was observed, and the identified fractions, apparently, can be sources of new functional peptides. Not only quantitative but also qualitative changes were observed in the studied samples. …”
Get full text