HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors by Viet-Khoa Tran-Nguyen, Ulrick Fineddie Randriharimanamizara, Olivier Taboureau

“…It also demonstrated superior screening power compared to virtual screening schemes that used existing scoring functions. This model, named “HERGAI,” along with relevant input/output data and user-friendly source code, is available in our GitHub repository ( https://github.com/vktrannguyen/HERGAI ) and can be used to predict drug-induced hERG blockade, even on large data sets.…”
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Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma. by Michele Vacca, Simona D'Amore, Giusi Graziano, Andria D'Orazio, Marica Cariello, Vittoria Massafra, Lorena Salvatore, Nicola Martelli, Stefania Murzilli, Giuseppe Lo Sasso, Renato Mariani-Costantini, Antonio Moschetta

“…Nuclear receptors (NRs) are key players in the control of cellular functions, being ideal modulators of hepatic proliferation and carcinogenesis.…”
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Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection. by Alex J McCarthy, David Negus, Patricia Martin, Catarina Pechincha, Eric Oswald, Richard A Stabler, Peter W Taylor

“…Only four single nucleotide polymorphisms (SNPs), in genes (gloB, yjgV, tdcE) or promoters (thrA) involved in metabolic functions, were found: no changes were detected in genes encoding virulence determinants associated with the invasive potential of E. coli K1. …”
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Soil pollution and remediation: emerging challenges and innovations by Hao Chen, Bin Gao, Yuncong Li

“…These pollutants pose severe risks to environmental health and agricultural productivity by altering soil functionality and contaminant mobility. This perspective summarizes innovative monitoring and remediation technologies, including advanced sensors and bioremediation strategies, that enable real-time detection and effective management of soil pollutants. …”
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Adoption barriers and facilitators of wearable health devices with AI integration: a patient-centred perspective by Haitham Alzghaibi

“…The research emphasises the necessity of user education, technical reliability, and professional oversight for the successful integration of AI-powered wearables in the management of chronic diseases.…”
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Late Presentation of Acromioclavicular Joint Dislocation with Double Fracture of Coracoid Process Managed by Arthroscopic Stabilization Technique: A Case Report by Anand Kumaroth Somasundaram, Aiswarya Mohan, Anjali Appukuttan

“…The patient was successfully treated using an arthroscopically assisted stabilization technique with tendon graft augmentation and an arthroscopic repair of a superior labral tear, which was diagnosed intraoperatively. …”
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Socioeconomic Inequity in Access to Medical and Long-Term Care Among Older People by Shohei Okamoto, Atsuhiro Yamada, Erika Kobayashi, Jersey Liang

“…Conclusion Improving the understanding of available resources and strengthening the functions of health centres and communities are required to detect the needs of citizens and facilitate their access to necessary care.…”
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Research on lightweight weed recognition algorithm based on improved YOLOv8 by Zhang Chao, Liu Bin, Li Kun

“…Different scale features are used to improve the performance of target detection. Finally, the MPDIoU loss function is replaced to enhance the convergence and stability of the model. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Relationship between weapon size and six key behavioural and physiological traits in males of the European earwig by Blackwell, Samantha E M, Pasquier, Laura, Dupont, Simon, devers, Severine, Lecureuil, Charlotte, Meunier, Joël

“…In many animals, male weapons are large and extravagant morphological structures that typically enhance fighting ability and reproductive success. It is generally assumed that growing and carrying large weapons is costly, thus only males in the best condition can afford it. …”
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Heritage in real life: between appreciation and contempt: why are modern Egyptians continuously losing their heritage? by Medhat Wassef

“…Being a part of the community myself and through direct contact with the people, I detected and extracted aspects of the Egyptian mindset on the grassroots level that played a significant role in the problem of heritage. …”
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Antioxidant potential of tree bark extracts: Insight from the multi-level output of the Antioxidant Power 1 assay. by Johanna Rehrl, Thomas Sepperer, Sissy Häsler Gunnarsdottir, Thomas Schnabel, Gertie Janneke Oostingh, Anja Schuster

“…Tree bark is a complex protective tissue that serves both physiological and defensive functions and is particularly rich in phenolic compounds bearing antioxidant, antimicrobial, anti-inflammatory and wound healing properties. …”
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Investigation of the Application of Machine Learning Algorithms in Credit Risk Assessment of Medium and Micro Enterprises by Yujie Zhao

“…Thus, this proposed method achieves 14.65% high-risk detection with 5.56% financial revisions for the industry considered by the data source.…”
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Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…ConclusionsIn clinical practice, our tool would enable the automated monitoring and detection of risk points throughout all clinical trial stages; accurately identify the most relevant trial procedure and function line; and notify quality management personnel, in real time, to take prompt actions and dynamically prevent the recurrence of quality issues.…”
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Research review of digital modeling technologies with 3D spatial visualization for pipelines by Xin LIU, Shengwen TU, Yanfang HOU, Dong LIN, Jie SHU, Yu TANG

“…These developments have resulted in more comprehensive functionalities for visualization systems and improved operational and maintenance efficiency. …”
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Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices by Eman Wajeh Ammen, Yehya Kamal Al-Bayati

“…Thus, the selective and sensitive detection of these drugs is crucial. Molecularly imprinted polymers (MIPs) are receptors that are designed to have a highly specific molecular recognition ability, which is the primary and crucial function of receptors. …”
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Patients’ and Health Care Professionals’ Perspectives on Remote Patient Monitoring in Chronic Obstructive Pulmonary Disease Exacerbation Management: Initiating Cocreation by Atena Mahboubian, Marise J Kasteleyn, Enna Bašić, Niels H Chavannes, Jiska J Aardoom

“…Early diagnosis of exacerbations is crucial for preserving lung function, preventing hospitalizations, and reducing health care costs. …”
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Learning Transferable Convolutional Proxy by SMI-Based Matching Technique by Wei Jin, Nan Jia

“…The classification responses are also smoothened by manifolds of both the source domain and proxy space. By minimizing an objective function of SMI, classification error, and manifold regularization, we learn the convolutional networks of both source and target domains. …”
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Removing Cardiac Artifacts From Single-Channel Respiratory Electromyograms by Eike Petersen, Julia Sauer, Jan GraBhoff, Philipp Rostalski

“…Electromyographic (EMG) measurements of the respiratory muscles provide a convenient and noninvasive way to assess respiratory muscle function and detect patient activity during assisted mechanical ventilation. …”
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Concurrent Validity and Inter-Rater Reliability of Hand-Held Measurements of Maximal Sprint Speed by Bartosz Zając, Paulina Gaj, Jakub Zięba

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