A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
Get full text

Comparative analysis of microwave indices for freeze/thaw state monitoring and adaptive thresholding implications by Zhicheng Yang, Tianjie Zhao, Qingfeng Wang, Lihua Peng, Youhua Ran, Yu Bai, Jingyao Zheng, Panpan Yao, Zhiqing Peng, Jinbiao Zhu, Xiaokang Kou, Yuei-An Liou, Jiancheng Shi

“…Near-surface soil freeze-thaw (F/T) cycles constitute a critical interface process regulating global hydrological dynamics, ecosystem succession, and climate feedback mechanisms. Leveraging its all-weather penetration capability, passive microwave remote sensing has emerged as a cornerstone for large-scale F/T state monitoring. …”
Get full text

Genomic signal selection analysis reveals genes related to the lambing trait of Hotan sheep by XinKun Wang, Wei Li, QiaoYan Huang, HuiPing Sun, LeXiao Zhu, RuoHuai Gu, Feng Xing

“…We identified 290 selected regions and 332 genes across the Hotan sheep genome by using two widely adopted selective scanning detection methods (FST statistics and Piratio). Functional annotation and enrichment analysis of these genes identified 13 genes associated with the lambing rate, which were enriched in pathways such as the transforming growth factor-β signaling pathway (BMPR2, ID2, SMAD7, THBS1, and RBX1), renal cell carcinoma (PAK1, ELOC), inositol phosphate metabolism (PLCZ), non-homologous terminal junction (RAD50), ABC transporters (ABCC4), and the NET pathway (H2B, H4, and H2A). …”
Get full text

Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling by Feginn Berle B, Juliussen S, Castilho Á, Solel E, Sdik Saed H, Vanderpoorten O, Lunavat TR, Thorsen F, Rigg E

“…Detection sensitivity was determined using agar phantoms, and in vivo tracking was validated through intramuscular injections in mice.Results: Uncoated 5 nm SPIONs demonstrated superior labeling efficiency, successfully marking over 90% of cells within 24 hours without significantly affecting cell growth. …”
Get full text

Parallel Jacobian Computation Based on Distance-2 Algorithm and Its Application in Coupling Problems by LIU Lixun, ZHANG Han, PENG Xinru, DOU Qinrong, WU Yingjie, GUO Jiong, LI Fu

“…In a word, this parallel coloring algorithm is successfully applied to the parallel Newton-Krylov method for solving the large-scale neutronic/thermal-hydraulics coupling problem.…”

Case Report: Post-operative mitral valve replacement complicating with a large cardiac mass and the role of TEE in Imaging [version 2; peer review: 2 approved] by Deepa Noronha, Chaithra Nayak, Syed Waleem Pasha, Padmanabh Kamath, Narasimha Pai D

“…The patient underwent successful mitral valve replacement as per ACC/AHA class I recommendation. …”
Get full text

Data Mining–Based Model for Computer-Aided Diagnosis of Autism and Gelotophobia: Mixed Methods Deep Learning Approach by Mohamed Eldawansy, Hazem El Bakry, Samaa M Shohieb

“…Accurate and automated detection tools could enhance early diagnosis and intervention. …”
Get full text

Additive Manufacturing for Automotive Radar Sensors Using Copper Inks and Pastes by Nihesh Mohan, Fabian Steinberger, Sonja Wächter, Hüseyin Erdogan, Gordon Elger

“…Radar sensors are critical for obstacle detection and navigation, especially for automated driving. …”
Get full text

Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Conclusions HAdV-7 successfully infects pulmonary vascular endothelium and replicates effectively, causing injury to the endothelium, high VEGF expression and viral load in the serum, as well as ALI/ARDS. …”
Get full text

IT: An interpretable transformer model for Alzheimer's disease prediction based on PET/MR images by Zhaomin Yao, Weiming Xie, Jiaming Chen, Ying Zhan, Xiaodan Wu, Yingxin Dai, Yusong Pei, Zhiguo Wang, Guoxu Zhang

“…These insights significantly bolster the arsenal of tools available for AD diagnostics and contribute to the broader narrative of deciphering brain functionality through state-of-the-art imaging modalities.…”
Get full text

Development of a two-layer 3D equine endometrial tissue model using genipin-crosslinked collagen scaffolds and 3D printing by Sawita Santiviparat, Setthibhak Suthithanakom, Sudchaya Bhanpattanakul, Sayamon Srisuwattanasagul, Kai Melde, Tom A. E. Stout, Theerawat Tharasanit

“…This model preserved the structural integrity necessary for glandular-like development and maintained the functional characteristics of equine endometrial tissue. …”
Get full text

Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…Moreover, biomonitoring campaigns often take place in urban environments, although sources can be located outside cities’ borders with ampler vegetation. …”
Get full text

Rapid flips between warm and cold extremes in a warming world by Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei

Get full text

Tailoring Atomic Ordering Uniformity Enables Selectively Leached Nanoporous Pd‐Ni‐P Metallic Glass for Enhanced Glucose Sensing by Yu Lou, Jian Li, Zhongzheng Yao, Zhenduo Wu, Huiqiang Ying, Lan Tan, Sinan Liu, Jianrong Zeng, Ruohan Yu, Hong Liu, Xun‐Li Wang, He Zhu, Si Lan

“…A microglucose sensor is successfully developed by integrating the nanoporous Pd‐Ni‐P MG with a screen‐printed electrode, demonstrating the practical applicability. …”
Get full text

TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
Get full text

Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…Postoperative follow-up demonstrated successful integration of the osteochondral graft and improved knee function scores over three years. …”
Get full text

The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression by Kai Guo, Jie Yao, Qiang Yu, Zijian Li, Hu Huang, Jianguo Cheng, Zhigang Wang, Yunfeng Zhu

“…Here, we reported for the first time that PVT1 as a long non-coding RNA was successfully detected in extracellular vesicles excluded from SW620 and SW480 cells, and the expression level of PVT1 was higher in extracellular vesicles from the more aggressive cell SW620 than from SW480. …”
Get full text

Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage by Ilgiz Gareev, Ozal Beylerli, Elmar Musaev, Chunlei Wang, Valentin Pavlov

“…TargetScan, miRDB, and RNA22 were used to investigate the miRNAs regulating the DEGs. The functional annotation of DEGs was performed using Gene Ontology (GO) resources, and the cell signaling pathway analysis of DEGs was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
Get full text

Cloning and expression of a C3H-type zinc finger protein gene BoCCCH2 from Brassica oleracea var. italica by JIANG Ming, LIU Qing’e, ZHANG Yanru, ZHU Qi, GONG Xiu, YU Keke, ZHOU Xiuqian

“…Cloning and expression analysis of BoCCCH2 provide evidence for further studies on gene function.…”
Get full text

Correlation and Agreement of Quantitative Flow Ratio With Fractional Flow Reserve in Saphenous Vein Grafts by Ruben W. de Winter, Yvemarie B. O. Somsen, Roel Hoek, Pepijn A. van Diemen, Ruurt A. Jukema, Mathé P. Jonker, Albert C. van Rossum, Jos W. R. Twisk, Rolf A. Kooistra, Jasper Janssen, Sina Porouchani, Adriaan Wilgenhof, Niels J. Verouden, Ibrahim Danad, Johan H. C. Reiber, Alexander Nap, Paul Knaapen

“…A threshold of ≤0.80 was used to define functional significance. QFR was successfully computed in 140 (93%) SVGs. …”
Get full text